Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,164

From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health

Papp, L. V., Lu, J., Holmgren, A., & Khanna, K. K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1528 · Cited by 1,357

Glutathione in Cancer Biology and Therapy

Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 792

Rho GTPases are over-expressed in human tumors

Fritz, G., Just, I., & Kaina, B. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990531)81:5 · Cited by 671

Chemopreventive Agents

Combs, G. F., & Gray, W. P. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00014-x · Cited by 667

Aberrant and Alternative Splicing in Cancer

Venables, J. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1910 · Cited by 644

Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis

Bjelaković, G., Nikolova, D., Simonetti, R. G., & Gluud, C. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17138-9 · Cited by 619

Effects of Selenoprotein W gene expression by selenium involves regulation of mRNA stability in chicken embryos neurons

Li, J., Li, H., Li, S., Gao, X., Xu, S., & Tang, Z. (2012) · BioMetals · doi:10.1007/s10534-012-9517-y · Cited by 21

A Whole-Genome SNP Association Study of NCI60 Cell Line Panel Indicates a Role of Ca2+ Signaling in Selenium Resistance

Savas, S., Briollais, L., Ibrahim-zada, I., Jarjanazi, H., Choi, Y., Musquera, M., Fleshner, N. E., Venkateswaran, V., & Özçelik, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012601 · Cited by 22

Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

Shu, N., Cheng, Q., Arnér, E. S. J., & Davies, M. J. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101335 · Cited by 22

Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite

Chatzakos, V., Rundlöf, A.-K., Ahmed, D., de Verdier, P. J., & Flygare, J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.06.009 · Cited by 21

Biosynthesis, Engineering, and Delivery of Selenoproteins

Wright, D., & O’Donoghue, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010223 · Cited by 21

Methylglyoxal-Induced Protection Response and Toxicity: Role of Glutathione Reductase and Thioredoxin Systems

Schmitz, A. E., de Souza, L. F., dos Santos, B., Maher, P. A., Lopes, F. M., Londero, G. F., Klamt, F., & Dafré, A. L. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9738-5 · Cited by 19

Multivariate analysis of trace elemental data obtained from blood serum of breast cancer patients using SRXRF

Naidu, B. G., Sarita, P., Raju, G. J. N., & Tiwari, M. K. (2018) · Results in Physics · doi:10.1016/j.rinp.2018.12.020 · Cited by 19

Selenium and Alzheimer's disease

Gu, J., Gu, J., & Yu, L. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110727 · Cited by 18

In vitro evaluation of bone cements impregnated with selenium nanoparticles stabilized by phosphatidylcholine (PC) for application in bone

Karahaliloğlu, Z., & Kılıçay, E. (2020) · Journal of Biomaterials Applications · doi:10.1177/0885328220933781 · Cited by 18

Multifunctional AuI‐based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics

Zhang, J., Zou, H., Lei, J., He, B., He, X., Sung, H. H. Y., Kwok, R. T. K., Lam, J. W. Y., Zheng, L., & Tang, B. Z. (2020) · Angewandte Chemie · doi:10.1002/ange.202000048 · Cited by 18

Comparison of trace element (selenium, iron), electrolyte (calcium, sodium), and physical activity levels in COVID-19 patients before and after the treatment

Özdemir, K., Saruhan, E., Benli, T. K., Kaya, G., Meral, O., Yavuz, M. Y., Şen, T., Kızıloğlu, İ., & Kavak, S. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127015 · Cited by 17

Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients

Pietrzak, S., Marciniak, W., Derkacz, R., Matuszczak, M., Kiljańczyk, A., Baszuk, P., Bryśkiewicz, M., Sikorski, A., Gronwald, J., Słojewski, M., et al. (2024) · Nutrients · doi:10.3390/nu16040527 · Cited by 17

Trace elements in nasal polyps

Okur, E., Gul, A., Kılınç, M., Kilic, M. A., Yıldırım, İ., Tolun, F. İ., & Atlı, Y. (2013) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-012-2319-6 · Cited by 16

Alteration of Thioredoxin Reductase 1 Levels in Elucidating Cancer Etiology

Yoo, M., Carlson, B. A., Tsuji, P. A., Irons, R., Gladyshev, V. N., & Hatfield, D. L. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)74015-5 · Cited by 15

Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

Tobe, R., Yoo, M., Fradejas‐Villar, N., Carlson, B. A., Calvo, S., Gladyshev, V. N., & Hatfield, D. L. (2012) · Biochemical Journal · doi:10.1042/bj20120618 · Cited by 15

Selenoproteins and Metastasis

Marciel, M. P., & Hoffmann, P. R. (2017) · Advances in cancer research · doi:10.1016/bs.acr.2017.07.008 · Cited by 15

Significant Changes in Metabolic Profiles after Intervention with Selenium and Coenzyme Q10 in an Elderly Population

Alehagen, U., Johansson, P., Aaseth, J., Alexander, J., Surowiec, I., Lundstedt‐Enkel, K., & Lundstedt, T. (2019) · Biomolecules · doi:10.3390/biom9100553 · Cited by 14

The Adjuvant Nutritional Intervention in Cancer (ANICA) Trial

Bjørklund, G. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1085582 · Cited by 13

Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status

Alehagen, U., Alexander, J., Aaseth, J., Larsson, A. O., & Lindahl, T. L. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02193-5 · Cited by 13

The Effect of Methylselenocysteine and Sodium Selenite Treatment on microRNA Expression in Liver Cancer Cell Lines

Lendvai, G., Szekerczés, T., Kontsek, E., Selvam, A. K., Szakos, A., Schaff, Z., Björnstedt, M., & Kiss, A. (2020) · Pathology & Oncology Research · doi:10.1007/s12253-020-00870-8 · Cited by 12

Association between changes in thioredoxin reductase and other peripheral blood biomarkers with response to PD-1 inhibitor-based combination immunotherapy in non-small cell lung cancer: a retrospective study

Wen, S., Du, X., Chen, Y., Xia, J., Wang, R., Zhu, M., Peng, W., Spitaleri, G., Hofman, P. M., Bironzo, P., et al. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-300 · Cited by 12

Selenium Digestibility and Bioactivity in Dogs: What the Can Can, the Kibble Can’t

Zelst, M. V., Hesta, M., Gray, K., Beech, K., Cools, A., Alexander, L. G., Laing, G. D., & Janssens, G. P. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152709 · Cited by 12

Selenium and Immunity

Nkengfack, G., Englert, H. S., & Haddadi, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_9 · Cited by 11

Targeting Reactive Oxygen Species for Diagnosis of Various Diseases

Lee, M. Y., Lee, D., Choi, D., Kim, K. S., & Kang, P. M. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15120378 · Cited by 11

Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans

Björkhem‐Bergman, L., Johansson, M. H., Morgenstern, R., Rane, A., & Ekström, L. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.10.005 · Cited by 10

The potential role of thioredoxin 1 and CD30 systems as multiple pathway targets and biomarkers in tumor therapy

Berghella, A. M., Pellegrini, P., Beato, T. D., Ciccone, F., & Contasta, I. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1068-5 · Cited by 10

Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells

Shen, X., Xia, Y., Lu, H., Zheng, P., Wang, J., Chen, Y., Xu, C., Qiu, C., Zhang, Y., Xiao, Z., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116507 · Cited by 9

Selenium Concentrations for Maximisation of Thioredoxin Reductase 2 Activity and Upregulation of Its Gene Transcripts in Senescent Human Fibroblasts

Ghneim, H. K. (2017) · Antioxidants · doi:10.3390/antiox6040083 · Cited by 9

Clinical Significance of Enzymes in Disease and Diagnosis

Ullah, M. F., Bhat, S. H., Tariq, M., & Abuduhier, F. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-25023-2_11 · Cited by 9

Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q10 in an Elderly Swedish Population: A Sub-Analysis

Alehagen, U., Aaseth, J., Larsson, A. O., & Alexander, J. (2022) · Cells · doi:10.3390/cells11030509 · Cited by 10

Methods for accurate and reproducible studies of pharmacological effects of selenium in cancer

Selvam, A. K., Szekerczés, T., Björnstedt, S., Razaghi, A., & Björnstedt, M. (2022) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2021.10.019 · Cited by 8

Acetylated Thioredoxin Reductase 1 Resists Oxidative Inactivation

Wright, D., Panaseiko, N., & O’Donoghue, P. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.747236 · Cited by 7

Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression

Xu, X., Hou, Y., Lin, S., Wang, K., Ren, Y., Zheng, T., Zhang, X., Li, M., & Fan, L. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2023.127147 · Cited by 7

Antioxidants in Cancer Treatment

César, J. (2011) · InTech eBooks · doi:10.5772/23131 · Cited by 7

Selenoglycoproteins attenuate adhesion of tumor cells to the brain microvascular endothelium via a process involving NF-κB activation

Wrobel, J. K., Choi, J. J., Xiao, R., Eum, S. Y., Kwiatkowski, S., Wolff, G., Spangler, L., Power, R. F., & Toborek, M. J. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.09.013 · Cited by 7

Cytotoxic and Radiosensitising Effects of a Novel Thioredoxin Reductase Inhibitor in Brain Cancers

Yao, A., Storr, S. J., Inman, M. W., Barwell, L., Moody, C. J., & Martin, S. G. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02808-4 · Cited by 6

Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer

Fan, T. W. ‐., Winnike, J. H., Al‐Attar, A., Belshoff, A. C., Lorkiewicz, P. K., Tan, J. L., Wu, M., Higashi, R. M., & Lane, A. N. (2023) · Metabolites · doi:10.3390/metabo13070774 · Cited by 7

Broken electron transfer pathway in enzyme: Gold clusters inhibiting TrxR1/Trx via cell studies and theory simulations

Niu, W., Du, Z., Zhang, C., Xu, D., Li, J., Sun, M., Wu, L., Yao, H., Zhao, L., & Gao, X. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.04.004 · Cited by 6

A bioassay-driven discovery of an unexpected selenophene and its cytotoxicity

Csük, R., Siewert, B., & Wiemann, J. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.04.036 · Cited by 6

In vitro evaluation of probiotic properties and selenium bioaccumulation of lactic acid bacteria isolated from poultry gastrointestinal, as an organic selenium source

Norouzi, S., Daneshyar, M., Farhoomand, P., Tukmechi, A., & Tellez-Isaiasc, G. (2023) · Research in Veterinary Science · doi:10.1016/j.rvsc.2023.06.012 · Cited by 5

Methylseleninic acid overcomes gefitinib resistance through asparagine-MET-TOPK signaling axis in non-small cell lung cancer cells

Cui, J., Zhao, S., Chen, H., Fu, Y., Han, K., Yin, S., Zhao, C., Fan, L., & Hu, H. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115690 · Cited by 5

Selenophosphate synthetase 1 (SPS1) is required for the development and selenium homeostasis of central nervous system in chicken (Gallus gallus)

Li, J., Li, W., Sun, X., Xia, J., Li, X.-N., Lin, J., Zhang, C., Xiao-Chen, S., & Xu, S. (2017) · Oncotarget · doi:10.18632/oncotarget.16283 · Cited by 5

Bioaccessible selenium sourced from Se-rich mustard cake facilitates protection from TBHP induced cytotoxicity in melanoma cells

Jaiswal, S. K., Prakash, R., Prabhu, K. S., & Prakash, N. T. (2018) · Food & Function · doi:10.1039/c7fo01644a · Cited by 4

Metal Complexes Stimulating Immunogenic Pyroptosis as Burgeoning Antitumor Strategy

Zheng, Y., Peng, K., Cao, Q., & Mao, Z. (2025) · Angewandte Chemie · doi:10.1002/ange.202507186 · Cited by 3

Selenium

Alexander, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822946-0.00035-0 · Cited by 3

Selenium-Functionalized Molecules (SeFMs) as Potential Drugs and Nutritional Supplements

Abdur, R., & Huang, Z. (2015) · Topics in medicinal chemistry · doi:10.1007/7355_2015_87 · Cited by 3

ROS-Responsive Nano-Encapsulated Selenium Targeting Cervical Cancer Cell via PI3K/AKT Signaling Pathway

Qiu, Y., Hu, C., Zhao, S., Chen, D., Shen, J., Dai, F., Ban, M., Ma, Y., Weng, J., Huang, X., et al. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s558115 · Cited by 2

Selenium Content in the Liver of Wistar Rats Fed Diets of Different Fatty Acid Quality

Barra, P. M. D. C., Sabarense, C. M., Alvarenga, M. B., de Sousa, R. A., & de Oliveira, M. A. L. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0359-7 · Cited by 2

Selenium Content in the Gonads of Healthy Cats (Felis catus) and Cats with Impaired Homeostasis from the Warsaw Area (Poland)

Skibniewska, E., & Skibniewski, M. (2024) · Animals · doi:10.3390/ani14030440 · Cited by 1

The diagnostic potential role of thioredoxin reductase and TXNRD1 in early lung adenocarcinoma: A cohort study

Jiang, G., Wang, X., Xu, Y., Zhao, H., Lu, R., Song, C., Jin, Y., Li, H., Wang, S., Zheng, M., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31864 · Cited by 1

Epidermal Growth Factor Stability and Cell Proliferation Enhanced by Antioxidants

Gowda, A. S. P., Schaefer, A. D., & Schuck, T. K. (2025) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2025.163004 · Cited by 1

Effects of selenomethionine on intestinal microbiota and its metabolism in mice infected with porcine deltacoronavirus

Li, H., Shi, Y., & Zhang, T. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1632166 · Cited by 1

Role of Selenium as an Antioxidant in Cancer Prevention: A Review

Qadir, A. M., & Omer, R. A. (2025) · Journal of Molecular and Engineering Materials · doi:10.1142/s2251237325300062 · Cited by 1

Selenomethionine Alleviates Spinal Cord Injury by Inhibiting Oxidative Damage–Mediated Neural Apoptosis and Ferroptosis

Li, P., Song, Q., Feng, X., Wang, Y., Chen, M., Sun, B., Yu, C., Yang, D., & Ni, Q. (2026) · Journal of Food Biochemistry · doi:10.1155/jfbc/4307443 · Cited by 2

Faculty Opinions recommendation of Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.

Lipton, S. A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725601011.793538932 · Cited by 1

The effect of redoxmodulation on osteoclastogenesis

Witte, S. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Molecular specificities of NK cell-mediated recognition of human tumor cells

Carlsten, M. (2010) · Figshare

Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal

Szulkin, A. (2014) · Figshare

Glutaredoxin-mediated selenite reduction triggers oxidative stress in Synechococcus elongatus PCC7942 cells

Gupta, B., Saggu, M., & Bagchi, D. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0362-y

Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes

Rapolu, C. (2011) · TopSCHOLAR (Western Kentucky University)

Comissão Nacional de Energia Nuclear - CNEN Centro de Desenvolvimento da Tecnologia Nuclear - CDTN Mestrado em Ciência e Tecnologia das Radiações, Materiais e Minerais Influência da ação oxidante do selênio na indução da radiossensibilidade e morte celular na levedura Saccharomyces cerevisiae

de Araujo, B. A., & Porto (2012)

Persistence of nucleic acid alkylation and selenoprotein inhibition by mycotoxins

Pietsch, K. E. (2012) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-007608294

Anticancer Effects of Auranofin in Human Lung Cancer Cells Through Increasing Intracellular ROS Levels and GSH DepletionPreprint

Park, S. H., Cui, X. Y., & Park, W. H. (2021) · Research Square · doi:10.21203/rs.3.rs-369523/v1

Evaluation of Some Antidepressants as Inhibitors of Thioredoxin Reductase Enzyme, which is an Anticancer Target

Felek, İ., & Akkemik, E. (2023) · European Journal of Science and Technology · doi:10.31590/ejosat.1293053

Exploring a multi-omics study of micronutrients and colon cancer riskPreprint

Wu, W., Gao, F., Gao, Z., Gao, H., Min, H., Wang, X., Chen, J., Xu, M., Zou, M., Gui, M.-B., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5816587/v1

Cationic liposome-based silencing of thioredoxin reductase-1 for sensitization of MDA-MB 231 cells to gamma radiation

Shelar, S. B., Basu, M., Hassan, P. A., & Barick, K. C. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.120100

Novel bioremediation processes for treatment of seleniferous soils and sediment

Wadgaonkar, S. L. (2017) · doi:10.70675/9eb94c4bz7569z4c37z8a56z8847c36e4a95

Instability of Fibroblast Growth Factor 2 in Cell Culture Media

Gowda, A. S. P., & Schaefer, A. D. (2026) · Natural Science · doi:10.4236/ns.2026.186008

Serum multi-element profiling and a Metallobalance index for noninvasive differentiation of canine prostatic adenocarcinoma: a pilot case-control study

Yamada, N., Ishigaki, K., Hayakawa, T., Iida, K., Yamaoka, S., Wang, P., & Asano, K. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1882881

Selenium and Human Disease: Balancing Essentiality, Deficiency and Toxicity

Josko, O. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017304

Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.

Gallegos, A. C., Berggren, M. I., Gasdaska, J. R., & Powis, G. (1997) · PubMed · Cited by 123

Selenium and the thioredoxin redox system: effects on cell growth and death.

Powis, G., Gasdaska, J. R., Gasdaska, P. Y., Berggren, M. I., Kirkpatrick, D. L., Engman, L., Cotgreave, I. A., Angulo, M., & Baker, A. F. (1997) · PubMed · Cited by 70

Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance

Björkhem‐Bergman, L. (2004) · Open Archive (Karolinska Institutet)

Selenium as a cancer-protective agent

Nedvědová, M. (2012) · Digital Repository (National Repository of Grey Literature)

Thioredoxin Reductase 1 as an Anticancer Drug Target

Schmidt, E. E., & Arnér, E. S. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-41283-2_16 · Cited by 9