Cited by 170Selenium in Biological SystemsOrganoselenium and organotellurium chemistryRedox biology and oxidative stress

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Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

Selenius, Markus, Rundlöf, Anna-Klara, Olm, Eric, Fernandes, Aristi P., Björnstedt, Mikael·2010·Antioxidants & Redox Signaling

DOI 10.1089/ars.2009.2884

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Abstract

Selenium is an essential element that is specifically incorporated as selenocystein into selenoproteins. It is a potent modulator of eukaryotic cell growth with strictly concentration-dependant effects. Lower concentrations are necessary for cell survival and growth, whereas higher concentrations inhibit growth and induce cell death. It is well established that selenium has cancer preventive effects, and several studies also have shown that it has strong anticancer effects with a selective cytotoxicity on malignant drug-resistant cells while only exerting marginal effects on normal and benign cells. This cancer-specific cytotoxicity is likely explained by high affinity selenium uptake dependent on proteins connected to multidrug resistance. One of the most studied selenoproteins in cancer is thioredoxin reductase (TrxR) that has important functions in neoplastic growth and is an important component of the resistant phenotype. Several reports have shown that TrxR is induced in tumor cells and pre-neoplastic cells, and several commonly used drugs interact with the protein. In this review, we summarize the current knowledge of selenium as a potent preventive and tumor selective anticancer drug, and we also discuss the potential of using the expression and modulation of the selenoprotein TrxR in the diagnostics and treatment of cancer.

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Authors: Selenius, M., Rundlöf, A.-K., Olm, E., Fernandes, A. P., & Björnstedt, M.
Affiliations: Karolinska University Hospital (SE)
ORCID: Fernandes, Aristi P.
Björnstedt, Mikael
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2010-04
Volume: 12
Issue: 7
Pages: 867-880
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2009.2884
OpenAlex: W2082202554
Cited by: 170
References: 158
Citations by year: 2026: 5 · 2025: 8 · 2024: 6 · 2023: 10 · 2022: 14 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 4 · 2015: 11 · 2014: 16 · 2013: 7 · 2012: 19
FWCI: 13.87
Type: journal article
Language: en
Open access: closed
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Cancerfonden
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: selenium, thioredoxin reductase, selenoproteins, selenocysteine, cancer prevention, anticancer agents, multidrug resistance, selenium uptake, tumor-specific cytotoxicity, cancer diagnosis, drug resistance
MeSH terms: Antioxidants, Clinical Trials as Topic, Exons, Humans, Neoplasms, Oxidation-Reduction, Selenium, Thioredoxin-Disulfide Reductase, Drug Design, Biomarkers, Oxidants, Alternative Splicing, Dietary Supplements

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Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

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