The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer
Abstract
Selenium is an essential element that is specifically incorporated as selenocystein into selenoproteins. It is a potent modulator of eukaryotic cell growth with strictly concentration-dependant effects. Lower concentrations are necessary for cell survival and growth, whereas higher concentrations inhibit growth and induce cell death. It is well established that selenium has cancer preventive effects, and several studies also have shown that it has strong anticancer effects with a selective cytotoxicity on malignant drug-resistant cells while only exerting marginal effects on normal and benign cells. This cancer-specific cytotoxicity is likely explained by high affinity selenium uptake dependent on proteins connected to multidrug resistance. One of the most studied selenoproteins in cancer is thioredoxin reductase (TrxR) that has important functions in neoplastic growth and is an important component of the resistant phenotype. Several reports have shown that TrxR is induced in tumor cells and pre-neoplastic cells, and several commonly used drugs interact with the protein. In this review, we summarize the current knowledge of selenium as a potent preventive and tumor selective anticancer drug, and we also discuss the potential of using the expression and modulation of the selenoprotein TrxR in the diagnostics and treatment of cancer.
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“A second crucial family of proteins containing SeCys and involved in redox biology is thioredoxin reductases (TRs), which contribute to the regulation of gene expression of multiple transcription factors implicated in inflammatory and cell cycle pathways (e.g., NF-kB and p53) [442], as well as in the recycling of antioxidant molecules [441].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [442]
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Selenoproteins: Molecular Pathways and Physiological Roles
Labunskyy, V. M., Hatfield, D. L., & Gladyshev, V. N. (2014) · Physiological Reviews · doi:10.1152/physrev.00039.2013 · Cited by 1,452
Selenium in human health and disease
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Metadata
- Authors
- Selenius, M., Rundlöf, A.-K., Olm, E., Fernandes, A. P., & Björnstedt, M.
- Affiliations
- Karolinska University Hospital (SE)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2010-04
- Volume
- 12
- Issue
- 7
- Pages
- 867-880
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2082202554
- Cited by
- 170
- References
- 158
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 10 · 2022: 14 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 4 · 2015: 11 · 2014: 16 · 2013: 7 · 2012: 19
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancerfonden
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- selenium, thioredoxin reductase, selenoproteins, selenocysteine, cancer prevention, anticancer agents, multidrug resistance, selenium uptake, tumor-specific cytotoxicity, cancer diagnosis, drug resistance
- MeSH terms
- Antioxidants, Clinical Trials as Topic, Exons, Humans, Neoplasms, Oxidation-Reduction, Selenium, Thioredoxin-Disulfide Reductase, Drug Design, Biomarkers, Oxidants, Alternative Splicing, Dietary Supplements
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