The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H 2 O 2 Signaling
Abstract
Mitochondria are the main source of reactive oxygen species in the cell. These reactive oxygen species have long been known as being involved in oxidative stress. This is a review of the mechanisms involved in reactive oxygen species generation by the respiratory chain and some of the dehydrogenases and the control by thermodynamic and kinetic constraints. Mitochondrial ROS produced at the level of the bc1 complex as well at the level of complex I are discussed. It was recognized more than a decade ago that they can also function as signaling molecules. This signaling role will be developed both in terms of mechanism and in terms of mitochondrial ROS signaling. The notion that hydrogen peroxide acts not only as a damaging oxidant but also as a signaling molecule was proposed more than a decade ago. Hydrogen peroxide signaling can be either direct (oxidation of its target) or indirect (involving peroxiredoxins, for example). The consequences of ROS signaling on crucial biologic processes such as cell proliferation and differentiation are discussed. Antioxid. Redox Signal. 14, 459—468.
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“It is well established that mitochondria produce ROS as a consequence of electron leak during respiration (223, 349).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [349]
In the citing paper
“Although some increases in ROS can stimulate these essential pathways, there is a threshold range of concentrations beyond which ROS become harmful (83, 206, 349).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [349]
Citations
Cites
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626
Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520
Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life
Halliwell, B. B. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.077073 · Cited by 2,402
H 2 O 2 , a Necessary Evil for Cell Signaling
Rhee, S. G. (2006) · Science · doi:10.1126/science.1130481 · Cited by 2,160
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727
Research works printed but not linked: 1
- Rigoulet M, , Mourier A, , Galinier A, , Casteilla L, , Devin A. Electron competition process in respiratory chain: regulatory mechanisms and physiological functions. Biochim Biophys Acta, 1797; 671–677. 2010.
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Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063
Pisoschi, A. M., Pop, A., Iordache, F., Stanca, L., Predoi, G., & Șerban, A. I. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112891 · Cited by 883
Role of peroxisomes in ros/rns-metabolism: Implications for human disease
Fransen, M., Nordgren, M., Wang, B., & Apanasets, O. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.001 · Cited by 644
Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme‐Catalyzed Cascade Reaction
Gao, S., Lin, H., Zhang, H., Yao, H., Chen, Y., & Shi, J. (2018) · Advanced Science · doi:10.1002/advs.201801733 · Cited by 648
Redox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
“Within the mitochondria, the enzymes of the TCA cycle supply reducing equivalents (NADH and FADH2) for ETC-mediated oxidative phosphorylation and production of ATP.”
BackgroundInfluential
Metadata
- Authors
- Rigoulet, M., Yoboue, E. D., & Devin, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-02
- Volume
- 14
- Issue
- 3
- Pages
- 459-468
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1985730402
- Semantic Scholar
- 72f038ebb891d7e56acea1d3220662223a95864f
- Cited by
- 394
- References
- 112
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 13 · 2023: 24 · 2022: 25 · 2021: 41 · 2020: 23 · 2019: 24 · 2018: 26 · 2017: 25 · 2016: 19 · 2015: 31 · 2014: 25 · 2013: 37 · 2012: 44
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- mitochondrial reactive oxygen species, hydrogen peroxide signaling, oxidative stress, electron transport chain, bc1 complex, complex I, dehydrogenase, peroxiredoxin, cell proliferation, cell differentiation
- MeSH terms
- Animals, Electron Transport, Hydrogen Peroxide, Mitochondria, Models, Molecular, Oxygen, Protein Conformation, Signal Transduction, Oxidants, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation
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