The DOI matches its Crossref record; 358 of the 358 references it cites were found in a registry or an index.
Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection
Open accessAbstract
SIGNIFICANCE: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated series of events that are amplified by endogenous signaling and culminating in oxidative damage to DNA, lipids, proteins, and many metabolites. Despite the global impact of IR, the molecular mechanisms underlying tissue damage reveal that many biomolecules are chemoselectively modified by IR. RECENT ADVANCES: The development of high-throughput "omics" technologies for mapping DNA and protein modifications have revolutionized the study of IR effects on biological systems. Studies in cells, tissues, and biological fluids are used to identify molecular features or biomarkers of IR exposure and response and the molecular mechanisms that regulate their expression or synthesis. CRITICAL ISSUES: In this review, chemical mechanisms are described for IR-induced modifications of biomolecules along with methods for their detection. Included with the detection methods are crucial experimental considerations and caveats for their use. Additional factors critical to the cellular response to radiation, including alterations in protein expression, metabolomics, and epigenetic factors, are also discussed. FUTURE DIRECTIONS: Throughout the review, the synergy of combined "omics" technologies such as genomics and epigenomics, proteomics, and metabolomics is highlighted. These are anticipated to lead to new hypotheses to understand IR effects on biological systems and improve IR-based therapies.
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Cited by
Polymerization Reactions and Modifications of Polymers by Ionizing Radiation
Ashfaq, A., Clochard, M.-C., Coqueret, X., Dispenza, C., Driscoll, M. S., Ulański, P., & Al-Sheikhly, M. (2020) · Polymers · doi:10.3390/polym12122877 · Cited by 459
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244
Lewis, J. E., Forshaw, T. E., Boothman, D. A., Furdui, C. M., & Kemp, M. L. (2021) · Cell Systems · doi:10.1016/j.cels.2020.12.001 · Cited by 61
Self-citationRadon Biomonitoring and microRNA in Lung Cancer
Bersimbaev, R., Pulliero, A., Bulgakova, O., Kussainova, A., Aripova, A., & Izzotti, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062154 · Cited by 53
Extracellular Vesicles in Modifying the Effects of Ionizing Radiation
Szatmári, T., Hargitai, R., Sáfrány, G., & Lumniczky, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225527 · Cited by 52
Metadata
- Authors
- Reisz, J. A., Bansal, N., Qian, J., Zhao, W., & Furdui, C. M.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2014-07-10
- Volume
- 21
- Issue
- 2
- Pages
- 260-292
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2326176611
- Cited by
- 833
- References
- 358
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- green
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