The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis
Abstract
SIGNIFICANCE: Nonalcoholic fatty liver disease (NAFLD), characterized by liver triacylglycerol build-up, has been growing in the global world in concert with the raised prevalence of cardiometabolic disorders, including obesity, diabetes, and hyperlipemia. Redox imbalance has been suggested to be highly relevant to NAFLD pathogenesis. Recent Advances: As a major health problem, NAFLD progresses to the more severe nonalcoholic steatohepatitis (NASH) condition and predisposes susceptible individuals to liver and cardiovascular disease. Although NAFLD represents the predominant cause of chronic liver disorders, the mechanisms of its development and progression remain incompletely understood, even if various scientific groups ascribed them to the occurrence of insulin resistance, dyslipidemia, inflammation, and apoptosis. Nevertheless, oxidative stress (OxS) more and more appears as the most important pathological event during NAFLD development and the hallmark between simple steatosis and NASH manifestation. CRITICAL ISSUES: The purpose of this article is to summarize recent developments in the understanding of NAFLD, essentially focusing on OxS as a major pathogenetic mechanism. Various attempts to translate reactive oxygen species (ROS) scavenging by antioxidants into experimental and clinical studies have yielded mostly encouraging results. FUTURE DIRECTIONS: Although augmented concentrations of ROS and faulty antioxidant defense have been associated to NAFLD and related complications, mechanisms of action and proofs of principle should be highlighted to support the causative role of OxS and to translate its concept into the clinic. Antioxid. Redox Signal. 26, 519-541.
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Cites
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Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
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Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242
Hassani Zadeh, S., Mansoori, A., & Hosseinzadeh, M. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15363 · Cited by 167
Danger signals in liver injury and restoration of homeostasis
Han, H., Desert, R., Das, S., Song, Z., Athavale, D., Ge, X., & Nieto, N. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.033 · Cited by 127
Han, X., Ding, C., Zhang, G., Pan, R., Liu, Y., Huang, N., Hou, N., Han, F., Xu, W., & Sun, X. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.032 · Cited by 63
Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview
Mantle, D., & Hargreaves, I. (2019) · Antioxidants · doi:10.3390/antiox8020044 · Cited by 63
Chen, X., Sun, X., Shen, T., Chen, Q., Chen, S., Pang, J., Mi, J., Tang, Y., You, Y., Xu, H., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.08.005 · Cited by 30
Huang, L., Zeng, X., Li, B., Wang, C., Zhou, M., Lang, H., Yi, L., & Mi, M. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00612-w · Cited by 23
Coenzyme Q10 Supplementation for Diabetes and Its Complications: An Overview
Mantle, D. (2017) · British Journal of Diabetes · doi:10.15277/bjd.2017.149 · Cited by 21
Recent research advances in metabolism, clinical and experimental
Boutari, C., Kokkorakis, M., Stefanakis, K., Valenzuela-Vallejo, L., Axarloglou, E., Volčanšek, Š., Chakhtoura, M., & Mantzoros, C. S. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155722 · Cited by 9
Metadata
- Authors
- Spahis, S., Delvin, E., Borys, J.-M., & Levy, E.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2017-04
- Volume
- 26
- Issue
- 10
- Pages
- 519-541
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2511630563
- Cited by
- 386
- References
- 19
- FWCI
- 27.26
- Type
- journal article
- Language
- en
- Open access
- closed
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