The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition
Open accessAbstract
SIGNIFICANCE: Impaired wound healing is a major complication of diabetes, and can lead to development of chronic foot ulcers in a significant number of patients. Despite the danger posed by poor healing, very few specific therapies exist, leaving patients at risk of hospitalization, amputation, and further decline in overall health. Recent Advances: Redox signaling is a key regulator of wound healing, especially through its influence on the extracellular matrix (ECM). Normal redox signaling is disrupted in diabetes leading to several pathological mechanisms that alter the balance between reactive oxygen species (ROS) generation and scavenging. Importantly, pathological oxidative stress can alter ECM structure and function. CRITICAL ISSUES: There is limited understanding of the specific role of altered redox signaling in the diabetic wound, although there is evidence that ROS are involved in the underlying pathology. FUTURE DIRECTIONS: Preclinical studies of antioxidant-based therapies for diabetic wound healing have yielded promising results. Redox-based therapeutics constitute a novel approach for the treatment of wounds in diabetes patients that deserve further investigation. Antioxid. Redox Signal. 27, 823-838.
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Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Crosstalk of reactive oxygen species and NF-κB signaling
Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095
Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound
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Cited by
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335
Cano Sanchez, M., Lancel, S., Boulanger, E., & Neviere, R. (2018) · Antioxidants · doi:10.3390/antiox7080098 · Cited by 574
Chlorella sp.-Ameliorated Undesirable Microenvironment Promotes Diabetic Wound Healing
Wu, H., Yang, P., Li, A., Jin, X., Zhang, Z., & Lv, H. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.06.012 · Cited by 65
Dai, S., Jiang, L., Liu, L., Su, Z., Yao, L., Yang, P., & Huang, N. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae119 · Cited by 43
Metadata
- Authors
- Kunkemoeller, B., & Kyriakides, T. R.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2017-10-20
- Volume
- 27
- Issue
- 12
- Pages
- 823-838
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2734455709
- Cited by
- 234
- References
- 18
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- green
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