CoChat
Sign Up
Cited by 118Diabetes Management and ResearchDiabetes Management and EducationDiabetes Treatment and Management

Hypoglycemia prevention and user acceptance of an insulin pump system with predictive low glucose management

Open access
Choudhary, Pratik, Olsen, Birthe S., Conget, Ignacio, Welsh, John B., Vorrink, Linda, Shin, John J.·2016·Diabetes Technology & Therapeutics
DOI 10.1089/dia.2015.0324PMC PMC4870649
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: The MiniMed 640G sensor-augmented insulin pump system (Medtronic, Inc., Northridge, CA) can automatically suspend insulin delivery in advance of predicted hypoglycemia and restart it upon recovery. The aims of this analysis were to determine the rate at which predicted hypoglycemia was avoided with this strategy, as well as to assess user acceptance of the system and its insulin management features. SUBJECTS AND METHODS: Forty subjects with type 1 diabetes used the system for 4 weeks. We retrospectively evaluated performance of the system, using downloaded pump and sensor data, and evaluated user acceptance via questionnaires. RESULTS: There were 2,322 suspend before low events (2.1 per subject-day). The mean (± SD) duration of pump suspension events was 56.4 ± 9.6 min, and the mean subsequent sensor glucose (SG) nadir was 71.8 ± 5.2 mg/dL. SG values following 1,930 (83.1%) of the predictive suspensions did not reach the preset low limit. Nadir SG values of ≤50 and ≤60 mg/dL were seen in 207 (8.9%) and 356 (15.3%) of the predictive suspensions, respectively. Blood glucose (BG) and SG values before and during the study were comparable (P > 0.05). The mean absolute relative difference between paired SG and BG values was 10.9 ± 13.8%. Subjects felt confident using the system, agreed that it helped protect them from hypoglycemia, and wished to continue using it. CONCLUSIONS: Automatic insulin pump suspension as implemented in the MiniMed 640G system can help patients avoid hypoglycemia, without significantly increasing hyperglycemia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1089/dia.2015.0324

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Numerous studies have demonstrated significant clinical benefits of CGM use in people with diabetes regardless of insulin delivery method.

    “Numerous studies have demonstrated significant clinical benefits of CGM use in people with diabetes regardless of insulin delivery method (1-15).”

    From Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range (2019) · cites this paper as [10]

    The Discussion (page unavailable) says the CGM-based MiniMed 640G pump system can help patients with type 1 diabetes avoid hypoglycemia. But this short, uncontrolled study examined a predictive pump-suspension system, not CGM use regardless of insulin delivery method; it does not establish a benefit across delivery methods or isolate the benefit of CGM itself. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 3

  1. De Bock MI, , Dart J, , George CE, , Abraham M, , Cooper M, , Paramalingam N, , Keenan B, , Spital G, , Roy A, , Davis EA, , Jones TW: Performance of a predictive insulin pump suspension algorithm for prevention of overnight hypoglycaemia [abstract]. Diabetes, 2014; 63:A240–A241.
  2. Veeze H, , Rasmussen LG, , Agrawal P, , Zhong A, , Arietta A, , Kooi N, , Liabat S, , Shah R, , Kaufman F: Real-life performance evaluation of the New Generation Enlite™ glucose sensor in patients with diabetes mellitus. Pediatr Diabetes, 2014; 15:100.
  3. Abraham M, , Davey R, , Paramalingam N, , Keenan B, , Ambler G, , Fairchild J, , Cameron F, , King B, , Jones T, , Davis E: Prevention of hypoglycaemia with predictive low glucose management system: comparison of hypoglycaemia induction with exercise and subcutaneous bolus [abstract]. Diabetes Technol Ther, 2014; 16:A43.

Cited by

Sorted by citations

Related

Authors
Choudhary, P., Olsen, B. S., Conget, I., Welsh, J. B., Vorrink, L., & Shin, J. J.
Affiliations
  • King's College London (GB)
  • Herlev Hospital (DK)
  • Clinic and University Hospital
  • Medtronic (Switzerland) (CH)
  • Medtronic (United States) (US)
Corresponding author
Choudhary, Pratik
ORCID
Venue
Diabetes Technology & Therapeutics
Publisher
SAGE Publications
Published
2016-05
Volume
18
Issue
5
Pages
288-291
ISSN
  • 1520-9156 (ISSN-L)
  • 1557-8593
DOI
10.1089/dia.2015.0324
PMC
PMC4870649
OpenAlex
W2330613462
Cited by
118
References
8
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 11 · 2019: 18 · 2018: 23 · 2017: 31 · 2016: 10
FWCI
27.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes Technology & Therapeutics (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
hypoglycemia prevention, type 1 diabetes, sensor-augmented pump, user acceptance, continuous glucose monitoring, hyperglycemia
MeSH terms
Adult, Blood Glucose, Child, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Retrospective Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review