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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Hypoglycemia Prevention and User Acceptance of an Insulin Pump System with Predictive Low Glucose Management

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Choudhary, Pratik, Olsen, Birthe S., Conget, Ignacio, Welsh, John B., Vorrink, Linda, Shin, John J.·2016·Diabetes Technology & Therapeutics
DOI 10.1089/dia.2015.0324PMC PMC4870649
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Abstract

BACKGROUND: The MiniMed 640G sensor-augmented insulin pump system (Medtronic, Inc., Northridge, CA) can automatically suspend insulin delivery in advance of predicted hypoglycemia and restart it upon recovery. The aims of this analysis were to determine the rate at which predicted hypoglycemia was avoided with this strategy, as well as to assess user acceptance of the system and its insulin management features. SUBJECTS AND METHODS: Forty subjects with type 1 diabetes used the system for 4 weeks. We retrospectively evaluated performance of the system, using downloaded pump and sensor data, and evaluated user acceptance via questionnaires. RESULTS: There were 2,322 suspend before low events (2.1 per subject-day). The mean (± SD) duration of pump suspension events was 56.4 ± 9.6 min, and the mean subsequent sensor glucose (SG) nadir was 71.8 ± 5.2 mg/dL. SG values following 1,930 (83.1%) of the predictive suspensions did not reach the preset low limit. Nadir SG values of ≤50 and ≤60 mg/dL were seen in 207 (8.9%) and 356 (15.3%) of the predictive suspensions, respectively. Blood glucose (BG) and SG values before and during the study were comparable (P > 0.05). The mean absolute relative difference between paired SG and BG values was 10.9 ± 13.8%. Subjects felt confident using the system, agreed that it helped protect them from hypoglycemia, and wished to continue using it. CONCLUSIONS: Automatic insulin pump suspension as implemented in the MiniMed 640G system can help patients avoid hypoglycemia, without significantly increasing hyperglycemia.

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FIG. 1. (A) Mean and SD of sensor glucose trajectories throughout suspend before low events lasting <30, 30 to <90, and ≥90 min. The line at 54 mg/dL (3.0 mmol/L) represents the most commonly used threshold value. (B) Number and proportion of nadir sensor glucose values following suspend before low events that were greater than the preset low limit (white) or were at or below the preset low limit (black).
FIG. 1. (A) Mean and SD of sensor glucose trajectories throughout suspend before low events lasting <30, 30 to <90, and ≥90 min. The line at 54 mg/dL (3.0 mmol/L) represents the most commonly used threshold value. (B) Number and proportion of nadir sensor glucose values following suspend before low events that were greater than the preset low limit (white) or were at or below the preset low limit (black).CC BY-NC · PubMed Central

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Research works printed but not linked: 3

  1. De Bock MI, , Dart J, , George CE, , Abraham M, , Cooper M, , Paramalingam N, , Keenan B, , Spital G, , Roy A, , Davis EA, , Jones TW: Performance of a predictive insulin pump suspension algorithm for prevention of overnight hypoglycaemia [abstract]. Diabetes, 2014; 63:A240–A241.
  2. Veeze H, , Rasmussen LG, , Agrawal P, , Zhong A, , Arietta A, , Kooi N, , Liabat S, , Shah R, , Kaufman F: Real-life performance evaluation of the New Generation Enlite™ glucose sensor in patients with diabetes mellitus. Pediatr Diabetes, 2014; 15:100.
  3. Abraham M, , Davey R, , Paramalingam N, , Keenan B, , Ambler G, , Fairchild J, , Cameron F, , King B, , Jones T, , Davis E: Prevention of hypoglycaemia with predictive low glucose management system: comparison of hypoglycaemia induction with exercise and subcutaneous bolus [abstract]. Diabetes Technol Ther, 2014; 16:A43.

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Metadata

Authors
Choudhary, P., Olsen, B. S., Conget, I., Welsh, J. B., Vorrink, L., & Shin, J. J.
Affiliations
  • King's College London (GB)
  • Herlev Hospital (DK)
  • Clinic and University Hospital
  • Medtronic (Switzerland) (CH)
  • Medtronic (United States) (US)
Corresponding author
Choudhary, Pratik
ORCID
Venue
Diabetes Technology & Therapeutics
Publisher
SAGE Publications
Published
2016-05
Volume
18
Issue
5
Pages
288-291
ISSN
  • 1520-9156 (ISSN-L)
  • 1557-8593
DOI
10.1089/dia.2015.0324
PMC
PMC4870649
OpenAlex
W2330613462
Cited by
118
References
8
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 11 · 2019: 18 · 2018: 23 · 2017: 31 · 2016: 10
FWCI
27.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes Technology & Therapeutics (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
hypoglycemia prevention, type 1 diabetes, sensor-augmented pump, user acceptance, continuous glucose monitoring, hyperglycemia
MeSH terms
Adult, Blood Glucose, Child, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Retrospective Studies

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