Cited by 244Antioxidant Activity and Oxidative StressRedox biology and oxidative stressConnexins and lens biology

Review: Oxidative Stress and Disease

SPECTOR, ABRAHAM·2000·Journal of Ocular Pharmacology and Therapeutics

Abstract

This communication briefly reviews aspects of oxidative stress and disease, particularly maturity onset cataract. The review considers a number of issues such as why lens and cataract research is important, what is oxidative stress, its relationship to disease and how does a tissue defend itself against such stress. Three diseases (chronic lung disease, diabetes and Alzheimer's disease) in which oxidative stress has differing roles are briefly discussed. The impact of oxidative stress upon the development of maturity onset cataract is considered and approaches are delineated which will establish the importance of such stress.

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Registry

Crossref · 10.1089/jop.2000.16.193

Cites

25 of 25 references verified0 citation errors · 0 not checkable

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  • With aging, decreased performance of the cell endogenous antioxidant system occurs, making elderly people more susceptible to oxidative stress.

    “With aging, a decreased performance of cell endogenous antioxidant system occurs; thus, elderly people are more susceptible to oxidative stress [2, 3].”

    From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [2]

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Authors
SPECTOR, A.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
SPECTOR, ABRAHAM
Venue
Journal of Ocular Pharmacology and Therapeutics
Published
2000-04
Volume
16
Issue
2
Pages
193-201
ISSN
  • 1080-7683 (ISSN-L)
  • 1557-7732
OpenAlex
W2090028564
Cited by
244
References
25
Citations by year
2026: 4 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 14 · 2013: 12 · 2012: 13
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Ocular Pharmacology and Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Eye Institute
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords
oxidative stress, lens, cataract, chronic lung disease, diabetes mellitus, Alzheimer's disease, antioxidant defense, pathogenesis
MeSH terms
Animals, Cataract, Humans, Lens, Crystalline, Reactive Oxygen Species, Oxidative Stress

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