The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury
Open accessAbstract
Cell transplantation therapies have become a major focus in pre-clinical research as a promising strategy for the treatment of spinal cord injury (SCI). In this article, we systematically review the available pre-clinical literature on the most commonly used cell types in order to assess the body of evidence that may support their translation to human SCI patients. These cell types include Schwann cells, olfactory ensheathing glial cells, embryonic and adult neural stem/progenitor cells, fate-restricted neural/glial precursor cells, and bone-marrow stromal cells. Studies were included for review only if they described the transplantation of the cell substrate into an in-vivo model of traumatic SCI, induced either bluntly or sharply. Using these inclusion criteria, 162 studies were identified and reviewed in detail, emphasizing their behavioral effects (although not limiting the scope of the discussion to behavioral effects alone). Significant differences between cells of the same “type” exist based on the species and age of donor, as well as culture conditions and mode of delivery. Many of these studies used cell transplantations in combination with other strategies. The systematic review makes it very apparent that cells derived from rodent sources have been the most extensively studied, while only 19 studies reported the transplantation of human cells, nine of which utilized bone-marrow stromal cells. Similarly, the vast majority of studies have been conducted in rodent models of injury, and few studies have investigated cell transplantation in larger mammals or primates. With respect to the timing of intervention, nearly all of the studies reviewed were conducted with transplantations occurring subacutely and acutely, while chronic treatments were rare and often failed to yield functional benefits.
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Cites
Keirstead, H. S., Nistor, G., Bernal, G., Totoiu, M., Cloutier, F., Sharp, K., & Steward, O. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0311-05.2005 · Cited by 1,250
McDonald, J. W., Liu, X.-Z., Qu, Y., Liu, S., Mickey, S. K., Turetsky, D., Gottlieb, D. I., & Choi, D. W. (1999) · Nature Medicine · doi:10.1038/70986 · Cited by 1,226
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
Hofstetter, C. P., Schwarz, E. J., Hess, D., Widenfalk, J., El Manira, A., Prockop, D. J., & Olson, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042678299 · Cited by 967
Teng, Y. D., Lavik, E. B., Qu, X., Park, K. I., Ourednik, J., Zurakowski, D., Langer, R., & Snyder, E. Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052678899 · Cited by 966
Repair of Adult Rat Corticospinal Tract by Transplants of Olfactory Ensheathing Cells
Li, Y., Field, P. M., & Raisman, G. (1997) · Science · doi:10.1126/science.277.5334.2000 · Cited by 869
Lu, P., Jones, L. L., Snyder, E. Y., & Tuszynski, M. H. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00037-2 · Cited by 867
Ramón-Cueto, A., Cordero, M. I., Santos-Benito, F. F., & Avila, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80905-8 · Cited by 790
cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
Pearse, D. D., Pereira, F. C., Marcillo, A. E., Bates, M. L., Berrocal, Y. A., Filbin, M. T., & Bunge, M. B. (2004) · Nature Medicine · doi:10.1038/nm1056 · Cited by 727
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
Cummings, B. J., Uchida, N., Tamaki, S. J., Salazar, D. L., Hooshmand, M., Summers, R., Gage, F. H., & Anderson, A. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507063102 · Cited by 714
Ramón-Cueto, A., Plant, G. W., Avila, J., & Bunge, M. B. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03803.1998 · Cited by 710
Cited by
Ahuja, C. S., Wilson, J. R., Nori, S., Kotter, M. R. N., Druschel, C., Curt, A., & Fehlings, M. G. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.18 · Cited by 2,441
Self-citationCell transplantation therapy for spinal cord injury
Assinck, P., Duncan, G. J., Hilton, B. J., Plemel, J. R., & Tetzlaff, W. (2017) · Nature Neuroscience · doi:10.1038/nn.4541 · Cited by 937
Self-citationCofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., & Garbossa, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112698 · Cited by 398
Restoration of sensorimotor functions after spinal cord injury
Dietz, V., & Fouad, K. (2014) · Brain · doi:10.1093/brain/awt262 · Cited by 288
Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Zipser, C. M., Cragg, J. J., Guest, J. D., Fehlings, M. G., Jutzeler, C. R., Anderson, A. J., & Curt, A. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00464-6 · Cited by 269
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Metadata
- Authors
- Tetzlaff, W., Okon, E. B., Karimi-Abdolrezaee, S., Hill, C. E., Sparling, J. S., Plemel, J. R., Plunet, W. T., Tsai, E. C., Baptiste, D., Smithson, L. J., Kawaja, M. D., Fehlings, M. G., & Kwon, B. K.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2011-08
- Volume
- 28
- Issue
- 8
- Pages
- 1611-1682
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W1997721049
- Cited by
- 598
- References
- 128
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tetzlaff, W., Okon, E. B., Karimi-Abdolrezaee, S., Hill, C. E., Sparling, J. S., Plemel, J. R., Plunet, W. T., Tsai, E. C., Baptiste, D., Smithson, L. J., Kawaja, M. D., Fehlings, M. G., & Kwon, B. K. (2011). A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury. Journal of Neurotrauma. https://doi.org/10.1089/neu.2009.1177
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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