Electrophysiology and Functional MRI in Post-Acute Mild Traumatic Brain Injury
Abstract
Symptoms persisting beyond the acute phase (>2 months) after a mild traumatic brain injury (MTBI) are often reported, but their origin remains controversial. Some investigators evoke dysfunctional cerebral mechanisms, while others ascribe them to the psychological consequences of the injury. We address this controversy by exploring possible cerebral dysfunction with functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) in a group of patients during the post-acute phase. Fourteen MTBI symptomatic patients (5.7±2.9 months post-injury) were tested with fMRI and ERP using a visual externally ordered working memory task, and were compared with 23 control subjects. Attenuated blood oxygen level dependent (BOLD) signal changes in the left and right mid-dorsolateral prefrontal cortex (mid-DLPFC), the putamen, the body of the caudate nucleus, and the right thalamus were found in the MTBI group compared with the control group. Moreover, symptom severity and BOLD signal changes were correlated: patients with more severe symptoms had lower BOLD signal changes in the right mid-DLPFC. For ERP, a group×task interaction was observed for N350 amplitude. A larger amplitude for the working memory task than for the control task was found in control subjects, but not in MTBI subjects, who had weak amplitudes for both tasks. This study confirms that persistent symptoms after MTBI cannot be uniquely explained by psychological factors, such as depression and/or malingering, and indicates that they can be associated with cerebral dysfunction. ERP reveals decreased amplitude of the N350 component, while fMRI demonstrates that the more severe the symptoms, the lower the BOLD signal changes in the mid-DLPFC.
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Functional MRI studies have detected significant alterations in brain activation patterns in individuals with persistent symptoms after mTBI.
“Functional MRI (fMRI) studies have detected significant alterations in brain activation patterns in individuals with persistent symptoms after mTBI [26, 74].”
From The neuropathology of sport (2014) · cites this paper as [74]
Cites
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Analysis of fMRI Time-Series Revisited
Friston, K. J., Holmes, A. P., Poline, J., Grasby, P. M., Williams, S., Frackowiak, R. S. J., & Turner, R. (1995) · NeuroImage · doi:10.1006/nimg.1995.1007 · Cited by 2,504 · see citing works
The P300 wave of the human event-related potential
Picton, T. W. (1992) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199210000-00002 · Cited by 1,908 · see citing works
Cassidy, J. D., Carroll, L., Peloso, P. M. J., Borg, J., von Holst, H., Holm, L. W., Kraus, J. F., & Coronado, V. G. (2004) · Journal of Rehabilitation Medicine · doi:10.1080/16501960410023732 · Cited by 1,612 · see citing works
Lateral prefrontal cortex: architectonic and functional organization
Petrides, M. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1631 · Cited by 1,212 · see citing works
Self-citationA General Statistical Analysis for fMRI Data
Worsley, K. J., Liao, C. H., Aston, J. A. D., Petre, V., Duncan, G. H., Morales, F., & Evans, A. C. (2002) · NeuroImage · doi:10.1006/nimg.2001.0933 · Cited by 1,170 · see citing works
Lovell, M. R., Iverson, G. L., Collins, M. W., Podell, K., Johnston, K. M., Pardini, D. A., Pardini, J., Norwig, J. A., & Maroon, J. C. (2006) · Applied Neuropsychology · doi:10.1207/s15324826an1303_4 · Cited by 684 · see citing works
Petrides, M., Alivisatos, B., Evans, A. C., & Meyer, E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.873 · Cited by 660 · see citing works
Self-citationDifferential Working Memory Load Effects after Mild Traumatic Brain Injury
McAllister, T. W., Sparling, M. B., Flashman, L. A., Guerin, S. J., Mamourian, A. C., & Saykin, A. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0899 · Cited by 510 · see citing works
McAllister, T. W., Saykin, A. J., Flashman, L. A., Sparling, M. B., Johnson, S. C., Guerin, S. J., Mamourian, A. C., Weaver, J. B., & Yanofsky, N. (1999) · Neurology · doi:10.1212/wnl.53.6.1300 · Cited by 476 · see citing works
Petrides, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00359.1995 · Cited by 464 · see citing works
Self-citationDe Beaumont, L., Theoret, H., Mongeon, D., Messier, J., Leclerc, S., Tremblay, S., Ellemberg, D., & Lassonde, M. (2009) · Brain · doi:10.1093/brain/awn347 · Cited by 416 · see citing works
Functional abnormalities in symptomatic concussed athletes: an fMRI study
Chen, J.-K., Johnston, K. M., Frey, S., Petrides, M., Worsley, K. J., & Ptito, A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.032 · Cited by 367 · see citing works
Self-citationPrefrontostriatal connections in relation to cortical architectonic organization in rhesus monkeys
Yeterian, E. H., & Pandya, D. N. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903120105 · Cited by 351 · see citing works
Chen, J.-K., Johnston, K., Collie, A., McCrory, P. R., & Ptito, A. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.110395 · Cited by 298 · see citing works
Self-citationLipton, M. L., Gulko, E., Zimmerman, M. E., Friedman, B. W., Kim, M., Gellella, E., Gold, T., Shifteh, K., Ardekani, B. A., & Branch, C. A. (2009) · Radiology · doi:10.1148/radiol.2523081584 · Cited by 291 · see citing works
Chen, J., Johnston, K. M., Petrides, M., & Ptito, A. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.8 · Cited by 267 · see citing works
Self-citationPeskind, E. R., Petrie, E. C., Cross, D. J., Pagulayan, K. F., McCraw, K. S., Hoff, D., Hart, K. L., Yu, C., Raskind, M. A., Cook, D. G., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.008 · Cited by 264 · see citing works
LONG-TERM AND CUMULATIVE EFFECTS OF SPORTS CONCUSSION ON MOTOR CORTEX INHIBITION
Beaumont, L. D., Lassonde, M. C., Leclerc, S., & Théoret, H. (2007) · Neurosurgery · doi:10.1227/01.neu.0000280000.03578.b6 · Cited by 237 · see citing works
Hughes, D., Jackson, A., Mason, D., Berry, E., Hollis, S., & Yates, D. W. (2004) · Neuroradiology · doi:10.1007/s00234-004-1227-x · Cited by 220 · see citing works
Neurophysiological Anomalies in Symptomatic and Asymptomatic Concussed Athletes
Gosselin, N., Thériault, M., Leclerc, S., Montplaisir, J. Y., & Lassonde, M. C. (2006) · Neurosurgery · doi:10.1227/01.neu.0000215953.44097.fa · Cited by 191 · see citing works
Self-citationThe Persistent Effects of Concussion on Neuroelectric Indices of Attention
Broglio, S. P., Pontifex, M. B., O'CONNOR, P. L., & Hillman, C. H. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0766 · Cited by 157 · see citing works
Missonnier, P., Deiber, M., Gold, G., Herrmann, F. R., Millet, P., Michon, A., Fazio‐Costa, L., Ibañez, V., & Giannakopoulos, P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.009 · Cited by 151 · see citing works
Concussions in athletes produce brain dysfunction as revealed by event-related potentials
Dupuis, F., Johnston, K. M., Lavoie, M. E., Leporé, F., & Lassonde, M. C. (2000) · Neuroreport · doi:10.1097/00001756-200012180-00035 · Cited by 145 · see citing works
Mcallister, T. W., Flashman, L. A., Sparling, M. B., & Saykin, A. J. (2004) · Brain Injury · doi:10.1080/02699050310001617370 · Cited by 143 · see citing works
Recovery from mild head injury.
Bernstein, D. M. (1999) · Brain Injury · doi:10.1080/026990599121683 · Cited by 137 · see citing works
Visual P300 Effects Beyond Symptoms in Concussed College Athletes
Lavoie, M. E., Dupuis, F., Johnston, K. M., Leclerc, S., & Lassonde, M. C. (2003) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.26.1.55.23936 · Cited by 136 · see citing works
Chen, S. A. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.3.326 · Cited by 129 · see citing works
Contributions of functional Magnetic Resonance Imaging (fMRI) to sport concussion evaluation
Ptito, A., Chen, J., & Johnston, K. M. (2007) · Neurorehabilitation · doi:10.3233/nre-2007-22308 · Cited by 119 · see citing works
Self-citationChen, J.-K., Johnston, K. M., Petrides, M., & Ptito, A. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e318170b59d · Cited by 112 · see citing works
Self-citationAugmented neural activity during executive control processing following diffuse axonal injury
Turner, G. R., & Levine, B. (2008) · Neurology · doi:10.1212/01.wnl.0000325640.18235.1c · Cited by 102 · see citing works
Gaetz, M., & Bernstein, D. (2001) · The journal of head trauma rehabilitation · doi:10.1097/00001199-200108000-00008 · Cited by 99 · see citing works
Auditory orienting and inhibition of return in mild traumatic brain injury: A FMRI study
Mayer, A. R., Mannell, M. V., Ling, J. M., Elgie, R., Gasparovic, C., Phillips, J., Doezema, D., & Yeo, R. A. (2009) · Human Brain Mapping · doi:10.1002/hbm.20836 · Cited by 98 · see citing works
Pardini, J., Pardini, D. A., Becker, J. T., Edelman, K. L., Eddy, W. F., Lovell, M. R., & Welling, J. S. (2010) · Neurosurgery · doi:10.1227/neu.0b013e3181ee33e2 · Cited by 82 · see citing works
Lachapelle, J., Bolduc-Teasdale, J., Ptito, A., & McKerral, M. (2008) · Brain Injury · doi:10.1080/02699050801938983 · Cited by 71 · see citing works
Self-citationA new electrophysiological index for working memory load in humans
Missonnier, P., Leonards, U., Gold, G., Palix, J., Ibáñez, V., & Giannakopoulos, P. (2003) · Neuroreport · doi:10.1097/00001756-200308060-00009 · Cited by 47 · see citing works
Traumatic Brain Injury and Forensic Neuropsychology
Bigler, E. D., & Brooks, M. (2009) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e31819c2190 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
American Medical Society for Sports Medicine position statement: concussion in sport
Harmon, K. G., Drezner, J. A., Gammons, M. R., Guskiewicz, K. M., Halstead, M., Herring, S. A., Kutcher, J. S., Pana, A., Putukian, M., & Roberts, W. O. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091941 · Cited by 1,433 · see citing works
The neuropathology of traumatic brain injury
McKee, A. C., & Daneshvar, D. H. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52892-6.00004-0 · Cited by 829 · see citing works
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422 · see citing works
American Medical Society for Sports Medicine Position Statement
Harmon, K. G., Drezner, J. A., Gammons, M. R., Guskiewicz, K. M., Halstead, M., Herring, S., Kutcher, J., Pana, A., Putukian, M., & Roberts, W. O. (2012) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e31827f5f93 · Cited by 318 · see citing works
Neuropathology of mild traumatic brain injury: relationship to neuroimaging findings
Bigler, E. D., & Maxwell, W. L. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-011-9145-0 · Cited by 311 · see citing works
Neurological consequences of traumatic brain injuries in sports
Ling, H., Hardy, J., & Zetterberg, H. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.03.012 · Cited by 197 · see citing works
Teo, W., Muthalib, M., Yamin, S., Hendy, A. M., Bramstedt, K., Kotsopoulos, E. J., Perrey, S., & Ayaz, H. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00284 · Cited by 177 · see citing works
Traumatic Brain Injury Detection Using Electrophysiological Methods
Rapp, P. E., Keyser, D. O., Albano, A. M., Hernandez, R. S., Gibson, D. B., Zambon, R. A., Hairston, W. D., Hughes, J., Krystal, A. D., & Nichols, A. S. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00011 · Cited by 177 · see citing works
Neuroimaging Biomarkers in Mild Traumatic Brain Injury (mTBI)
Bigler, E. D. (2013) · Neuropsychology Review · doi:10.1007/s11065-013-9237-2 · Cited by 166 · see citing works
Katz, D. I., Cohen, S. I., & ALEXANDER, M. P. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52892-6.00009-x · Cited by 166 · see citing works
Visual problems associated with traumatic brain injury
Armstrong, R. A. (2018) · Clinical and Experimental Optometry · doi:10.1111/cxo.12670 · Cited by 163 · see citing works
McDonald, B. C., Saykin, A. J., & McAllister, T. W. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9173-4 · Cited by 154 · see citing works
Makdissi, M., Cantu, R. C., Johnston, K. M., McCrory, P. R., & Meeuwisse, W. H. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092255 · Cited by 155 · see citing works
Soft and MRI Compatible Neural Electrodes from Carbon Nanotube Fibers
Lu, L., Fu, X., Liew, Y., Zhang, Y., Zhao, S., Xu, Z., Zhao, J., Li, D., Li, Q., Stanley, G. B., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b04456 · Cited by 146 · see citing works
Embracing chaos: the scope and importance of clinical and pathological heterogeneity in mTBI
Rosenbaum, S. B., & Lipton, M. L. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9162-7 · Cited by 142 · see citing works
Functional magnetic resonance imaging of mild traumatic brain injury
Mayer, A. R., Bellgowan, P. S. F., & Hanlon, F. M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.016 · Cited by 141 · see citing works
Lee, H., Sullivan, S. J., & Schneiders, A. G. (2012) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2012.03.013 · Cited by 138 · see citing works
Differential Eye Movements in Mild Traumatic Brain Injury Versus Normal Controls
Cifu, D. X., Wares, J. R., Hoke, K., Wetzel, P. A., Gitchel, G. T., & Carne, W. F. (2014) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000036 · Cited by 123 · see citing works
Diagnostic Tests for Concussion
Ventura, R. E., Jancuska, J. M., Balcer, L. J., & Galetta, S. L. (2015) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000223 · Cited by 104 · see citing works
Time Course of Clinical and Electrophysiological Recovery After Sport-Related Concussion
Prichep, L. S., McCrea, M., Barr, W., Powell, M. R., & Chabot, R. J. (2012) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e318247b54e · Cited by 102 · see citing works
Makdissi, M., Davis, G. A., Jordan, B. D., Patricios, J., Purcell, L. K., & Putukian, M. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092256 · Cited by 98 · see citing works
Evaluation and management of mild traumatic brain injury
Barbosa, R. R., Jawa, R. S., Watters, J. M., Knight, J. C., Kerwin, A. J., Winston, E. S., Barraco, R. D., Tucker, B., Bardes, J. M., & Rowell, S. (2012) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3182701885 · Cited by 96 · see citing works
Gosselin, N., Bottari, C. L., Chen, J., Huntgeburth, S. C., Beaumont, L. D., Petrides, M., Cheung, B., & Ptito, A. (2012) · Neurosurgical FOCUS · doi:10.3171/2012.10.focus12253 · Cited by 95 · see citing works
Self-citationInfluence of Physical Exercise on Traumatic Brain Injury Deficits: Scaffolding Effect
Archer, T. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9297-0 · Cited by 90 · see citing works
What’s New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment
Reis, C., Wang, Y., Akyol, O., Ho, W., Applegate, R. L., Stier, G. R., Martin, R., & Zhang, J. H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160611903 · Cited by 86 · see citing works
Assessment of an Experimental Rodent Model of Pediatric Mild Traumatic Brain Injury
Mychasiuk, R., Farran, A., & Esser, M. J. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.3132 · Cited by 78 · see citing works
Myer, G. D., Yuan, W., Foss, K. D. B., Smith, D. W., Altaye, M., Reches, A., Leach, J. L., Kiefer, A. W., Khoury, J. C., Weiss, M., et al. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00074 · Cited by 74 · see citing works
Microenvironment changes in mild traumatic brain injury
Kan, E. M., Ling, E., & Lu, J. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.01.007 · Cited by 72 · see citing works
Iverson, G. L., & Lange, R. T. (2010) · Springer eBooks · doi:10.1007/978-0-387-76978-3_22 · Cited by 68 · see citing works
MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update
Wu, X. C., Kirov, I. I., Gonen, O., Ge, Y., Grossman, R. I., & Lui, Y. W. (2016) · Radiology · doi:10.1148/radiol.16142535 · Cited by 60 · see citing works
Wylie, G. R., Freeman, K., Thomas, A. W., Shpaner, M., O’Keefe, M. F., Watts, R., & Naylor, M. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126110 · Cited by 59 · see citing works
Hocke, L. M., Duszynski, C. C., Debert, C. T., Dleikan, D., & Dunn, J. F. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5365 · Cited by 55 · see citing works
Neural Recruitment after Mild Traumatic Brain Injury Is Task Dependent: A Meta-analysis
Bryer, E. J., Medaglia, J. D., Rostami, S., & Hillary, F. G. (2013) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617713000490 · Cited by 52 · see citing works
Sinopoli, K. J., Chen, J., Wells, G. D., Fait, P. E., Ptito, A., Taha, T., & Keightley, M. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3326 · Cited by 50 · see citing works
Self-citationDetecting Mild Traumatic Brain Injury Using Resting State Magnetoencephalographic Connectivity
Vakorin, V. A., Doesburg, S. M., da Costa, L., Jetly, R., Pang, E. W., & Taylor, M. J. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004914 · Cited by 49 · see citing works
Lack of long-term fMRI differences after multiple sports-related concussions
Terry, D. P., Faraco, C. C., Smith, D., Diddams, M. J., Puente, A. N., & Miller, L. S. (2012) · Brain Injury · doi:10.3109/02699052.2012.722259 · Cited by 48 · see citing works
Cognitive Neuroscience of Memory
Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687 · Cited by 48 · see citing works
Wright, A. D., Smirl, J. D., Bryk, K. N., & van Donkelaar, P. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5020 · Cited by 47 · see citing works
Tallus, J., Lioumis, P., Hämäläinen, H., Kähkönen, S., & Tenovuo, O. S. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2760 · Cited by 41 · see citing works
Oehr, L. E., & Anderson, J. F. I. (2017) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2017.03.019 · Cited by 42 · see citing works
Roitman, P., Gilad, M., Ankri, Y. L. E., & Shalev, A. Y. (2013) · Journal of Traumatic Stress · doi:10.1002/jts.21862 · Cited by 42 · see citing works
Advanced Neuroimaging of Mild Traumatic Brain Injury
Koerte, I. K., Hufschmidt, J., Muehlmann, M., Lin, A. P., & Shenton, M. E. (2016) · Europe PMC (PubMed Central) · Cited by 39 · see citing works
Cognitive support technologies for people with TBI: current usage and challenges experienced
Chu, Y., Brown, P. A., Harniss, M. K., Kautz, H., & Johnson, K. L. (2013) · Disability and Rehabilitation Assistive Technology · doi:10.3109/17483107.2013.823631 · Cited by 33 · see citing works
Cook, M. J., Gardner, A. J., Wojtowicz, M. A., Williams, W. H., Iverson, G. L., & Stanwell, P. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102129 · Cited by 30 · see citing works
Opie, G. M., Foo, N., Killington, M., Ridding, M. C., & Semmler, J. G. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6353 · Cited by 29 · see citing works
McBride, J., Zhao, X., Nichols, T., Vagnini, V. L., Munro, N. B., Berry, D., & Jiang, Y. (2012) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2012.2223698 · Cited by 28 · see citing works
History of concussion impacts electrophysiological correlates of working memory
Hudac, C. M., Cortesa, C. S., Ledwidge, P. S., & Molfese, D. L. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.09.020 · Cited by 27 · see citing works
Murugan, M., Santhakumar, V., & Kannurpatti, S. S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00019 · Cited by 26 · see citing works
Hershaw, J. N., Hill-Pearson, C. A., Arango, J. I., Souvignier, A. R., & Pazdan, R. M. (2019) · Military Medicine · doi:10.1093/milmed/usz335 · Cited by 24 · see citing works
Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review
Mortaheb, S., Filippini, M. M., Kaux, J., Annen, J., Lejeune, N., Martens, G., Calderón, M. A. F., Laureys, S., & Thibaut, A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.687197 · Cited by 23 · see citing works
Carbon-Based Fiber Materials as Implantable Depth Neural Electrodes
Fu, X., Li, G., Niu, Y., Xu, J., Wang, P., Zhou, Z., Ye, Z., Liu, X., Xu, Z. J., Yang, Z., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.771980 · Cited by 22 · see citing works
Neurologically-related sequelae associated with mild traumatic brain injury
Webb, T., Whitehead, C. R., Wells, T. S., Gore, R. K., & Otte, C. N. (2014) · Brain Injury · doi:10.3109/02699052.2014.989904 · Cited by 21 · see citing works
Microstructural Integrity of Hippocampal Subregions Is Impaired after Mild Traumatic Brain Injury
Leh, S. E., Schroeder, C., Chen, J., Chakravarty, M. M., Park, M. T. M., Cheung, B., Huntgeburth, S. C., Gosselin, N., Höck, C., Ptito, A., et al. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4591 · Cited by 21 · see citing works
Self-citationThe Influence of Pain on Cerebral Functioning after Mild Traumatic Brain Injury
Gosselin, N., Chen, J., Bottari, C. L., Petrides, M., Jubault, T., Tinawi, S., de Guise, É., & Ptito, A. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2312 · Cited by 21 · see citing works
Self-citationPsychogenic Explanations of Physical Illness
Wilshire, C. E., & Ward, T. J. (2016) · Perspectives on Psychological Science · doi:10.1177/1745691616645540 · Cited by 20 · see citing works
Terry, D., Adams, T. E., Ferrara, M. S., & Miller, L. S. (2015) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acv020 · Cited by 19 · see citing works
A functional MRI study of presurgical cognitive deficits in glioma patients
Schouwenaars, I. T., de Dreu, M. J., Rutten, G.-J. M., Ramsey, N. F., & Jansma, J. M. (2020) · Neuro-Oncology Practice · doi:10.1093/nop/npaa059 · Cited by 17 · see citing works
Neuroendocrine dysfunction and insomniain mild traumatic brain injury patients
Zhou, D., Zhao, Y., Wan, Y., Wang, Y., Xie, D., Lu, Q., Yang, S., & Qi, X. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.055 · Cited by 16 · see citing works
Multimodal Analysis: New Approaches to the Concussion Conundrum
Thompson, J. W. G., & Hagedorn, D. (2012) · Journal of Clinical Sport Psychology · doi:10.1123/jcsp.6.1.22 · Cited by 15 · see citing works
Tóth, A. (2015) · CRC Press/Taylor & Francis, Boca Raton (FL) eBooks · Cited by 14 · see citing works
Gumus, M., Santos, A. C., & Tartaglia, M. C. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-326604 · Cited by 14 · see citing works
Candrian, G., Müller, A. F., Dall’Acqua, P., Kompatsiari, K., Baschera, G.-M., Mica, L., Simmen, H., Glaab, R., Fandino, J., Schwendinger, M., et al. (2017) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2017.07.246 · Cited by 14 · see citing works
Animal Models of Traumatic Brain Injury and Their Relevance in Clinical Settings
Chauhan, P., Yadav, N. S., Wadhwa, K., Ganesan, S., Walia, C., Rathore, G., Singh, G., Abomughaid, M. M., Ahlawat, A., Alexiou, A. T., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70362 · Cited by 13 · see citing works
Bottari, C. L., Gosselin, N., Chen, J., & Ptito, A. (2015) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2015.1110528 · Cited by 13 · see citing works
Self-citationAli, H. T., Sula, I., AbuHamdia, A., Elejla, S. A., Elrefaey, A., Hamdar, H., & Elfil, M. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02193-8 · Cited by 11 · see citing works
Eyolfson, E., Yamakawa, G. R., Griep, Y., Collins, R., Carr, T. H., Wang, M., Lohman, A. W., & Mychasiuk, R. (2020) · Cerebral Cortex Communications · doi:10.1093/texcom/tgaa002 · Cited by 11 · see citing works
Coyle, H. L., Bailey, N. W., Ponsford, J., & Hoy, K. E. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114308 · Cited by 10 · see citing works
Clinical Utility of Oculomotor and Electrophysiological Measures in Identifying Concussion History
Ledwidge, P. S., Patterson, J. N., Molfese, D. L., & Honaker, J. A. (2017) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000000512 · Cited by 10 · see citing works
Electrophysiology reveals cognitive-linguistic alterations after concussion
Ledwidge, P. S., Jones, C. M., Huston, C. A., Trenkamp, M., Bator, B., & Laeng, J. (2022) · Brain and Language · doi:10.1016/j.bandl.2022.105166 · Cited by 9 · see citing works
Event-related potentials of episodic encoding after traumatic brain injury in older adults
Fortin, J. A., Grondin, S., & Blanchet, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147504 · Cited by 9 · see citing works
Hung, Y., Vandewouw, M. M., Emami, Z., Bells, S., Rudberg, N., da Costa, L., & Dunkley, B. T. (2022) · Human Brain Mapping · doi:10.1002/hbm.26003 · Cited by 8 · see citing works
Runyan, A. C., Philippi, C. L., Pessin, S., Velez, C. S., Wade, B., Drennon, A. M., Cooper, D. B., Kennedy, J. E., Bowles, A. O., Lewis, J. D., et al. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148099 · Cited by 8 · see citing works
Fox, A. J., Matthews, N. L., Qiu, Z., Filmer, H. L., & Dux, P. E. (2024) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2024.109005 · Cited by 8 · see citing works
de Guise, É., LeBlanc, J., Tinawi, S., Lamoureux, J., & Feyz, M. (2012) · ISRN Rehabilitation · doi:10.5402/2012/147285 · Cited by 7 · see citing works
Self-citationOeur, A., Torp, W. H., Arbogast, K. B., Master, C. L., & Margulies, S. S. (2023) · Biomedicines · doi:10.3390/biomedicines11071816 · Cited by 6 · see citing works
Hu, H. Z., Lu, H., He, Z., Han, X., Chen, J., & Tu, R. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.21.009 · Cited by 6 · see citing works
Self-citationEvent-Related Potentials as Biomarkers of Mild Traumatic Brain Injury
Gomes, J., & Damborská, A. (2017) · Activitas Nervosa Superior · doi:10.1007/s41470-017-0011-2 · Cited by 6 · see citing works
Rivara, F. P. (2012) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2011.1602 · Cited by 6 · see citing works
Functional Magnetic Resonance Imaging in Mild Traumatic Brain Injury
Mayer, A. R., & Bellgowan, P. S. F. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0295-8_14 · Cited by 5 · see citing works
Emotional Modulation of Frontal Alpha Asymmetry - a Novel Biomarker of Mild Traumatic Brain Injury
Kuusinen, V., Peräkylä, J., Sun, L., Ogawa, K. H., & Hartikainen, K. M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.699947 · Cited by 5 · see citing works
Emerging themes from the literature on circulating biomarkers of traumatic brain injury
Paziana, K., & Korley, F. K. (2015) · Future Neurology · doi:10.2217/fnl.15.13 · Cited by 4 · see citing works
Bolduc-Teasdale, J., Jolicœur, P., & McKerral, M. (2012) · Journal of Ophthalmology · doi:10.1155/2012/618654 · Cited by 4 · see citing works
Types of Memory and Brain Regions of Interest
Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.002 · Cited by 4 · see citing works
Zhang, J., Wang, R., Wang, H., Li, Y., Zhang, H., Dong, L., & Zhang, H. (2020) · Europe PMC (PubMed Central) · Cited by 4 · see citing works
Mavroudis, I. A., Petridis, F., Ciobica, A. S., Kamal, F. Z., Pădurariu, M., & Kazis, D. A. (2025) · Acta Neurologica Belgica · doi:10.1007/s13760-024-02695-7 · Cited by 3 · see citing works
Synaptic Plasticity in the Injured Brain Depends on the Temporal Pattern of Stimulation
Fischer, Q. S., Kalikulov, D., Prisco, G. V. D., Williams, C. A., Baldwin, P. R., & Friedlander, M. J. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2024.0129 · Cited by 3 · see citing works
Imaging Findings in Mild Traumatic Brain Injury
Kulich, M., Fisher, L. M., & Voelker, C. C. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812344-7.00003-0 · Cited by 3 · see citing works
Dynamic Complexity and Causality Analysis of Scalp EEG for Detection of Cognitive Deficits
McBride, J. C. (2014) · Cited by 2 · see citing works
What Is a Concussive Brain Injury?
Victoroff, J., & Bigler, E. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139696432.003 · Cited by 2 · see citing works
Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.008 · Cited by 2 · see citing works
González‐Garrido, A. A., González-González, J. M., Gómez‐Velázquez, F. R., Villaseñor, T., Flores-Barrios, A., & Aguirre-Portillo, L. (2013) · International Journal of Psychological Studies · doi:10.5539/ijps.v5n4p38 · Cited by 1 · see citing works
Raikes, A. C. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/ddcb-4722 · Cited by 1 · see citing works
Shorer, M., Fennig, S., Apter, A. S., & Peleg, T. P. (2021) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2021.101711 · Cited by 1 · see citing works
The Tools of Cognitive Neuroscience
Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.003 · Cited by 1 · see citing works
Churchill, N. W. (2022) · Springer eBooks · doi:10.1007/978-3-030-93813-0_3 · Cited by 1 · see citing works
Mavroudis, I. A., Petridis, F., Ciobica, A. S., Kamal, F. Z., & Pădurariu, M. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007685 · Cited by 2 · see citing works
Ricker, J. M., Smith, K., Schmidt, A., Cripps, A. E., Thalla, P., Cromwell, H. C., & Wang, X. (2021) · Journal of Sports Medicine and Allied Health Sciences Official Journal of the Ohio Athletic Trainers Association · doi:10.25035/jsmahs.07.02.03 · Cited by 1 · see citing works
Fatigue and cognition - hormonal perspectives
Möller, M. C. (2012) · Figshare
Urban, K. J. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/26855
- Authors
- Gosselin, N., Bottari, C., Chen, J.-K., Petrides, M., Tinawi, S., de Guise, É., & Ptito, A.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- University of Toronto (CA)
- Montreal General Hospital (CA)
- Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
- Corresponding author
- Ptito, Alain
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2011-03
- Volume
- 28
- Issue
- 3
- Pages
- 329-341
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2053912118
- Cited by
- 124
- References
- 38
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 22 · 2016: 10 · 2015: 15 · 2014: 7 · 2013: 10 · 2012: 19
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Foundation
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- mild traumatic brain injury, post-concussion syndrome, dorsolateral prefrontal cortex, BOLD signal changes, event-related potentials, working memory, thalamus, caudate nucleus, putamen, symptom severity, brain dysfunction
- MeSH terms
- Adult, Analysis of Variance, Attention, Brain, Brain Injuries, Brain Mapping, Electroencephalography, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Reaction Time, Severity of Illness Index
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