The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
MicroRNA Let-7i Is a Promising Serum Biomarker for Blast-Induced Traumatic Brain Injury
Abstract
Blast-induced traumatic brain injury (TBI) is of significant concern in soldiers returning from the current conflicts in Iraq and Afghanistan. Incidents of TBI have increased significantly in the current conflicts compared to previous wars, and a majority of these injuries are caused by improvised explosive devices. Currently, no specific technique or biomarker is available for diagnosing TBI when no obvious clinical symptoms are present. MicroRNAs are small RNA (∼ 22nts) molecules that are expressed endogenously and play an important role in regulating gene expression. MicroRNAs have emerged as novel serum diagnostic biomarkers for various diseases. In this study, we studied the effect of blast overpressure injury on the microRNA signatures in the serum of rats. Rats were exposed to three serial 120-kPa blast overpressure exposures through a shockwave tube. Blood and cerebrospinal fluid were collected at various time points after injury, and microRNA modulation was analyzed using real-time PCR. Five microRNAs were significantly modulated in the serum samples of these animals at three time points post-injury. Further, we also found that the levels of microRNA let-7i are also elevated in cerebrospinal fluid post-blast wave exposure. The presence of microRNA in both serum and cerebrospinal fluid immediately after injury makes microRNA let-7i an ideal candidate for further studies of biomarkers in TBI.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Hippocampal levels of let-7i decline after pilocarpine-induced SE (Risbud and Porter, 2013) but increase in the plasma after traumatic brain injury in rats (Balakathiresan et al., 2012), suggesting circulating let-7i may be a broad biomarker for epileptogenic brain injuries.”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Balakathiresan et al., 2012
Experimental — accuracy not yet measuredIn the citing paper
“Hippocampal levels of let-7i decline after pilocarpine-induced SE (Risbud and Porter, 2013) but increase in the plasma after traumatic brain injury in rats (Balakathiresan et al., 2012), suggesting circulating let-7i may be a broad biomarker for epileptogenic brain injuries.”
From Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy (2023) · cites this paper as Balakathiresan et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MicroRNA expression in the adult mouse central nervous system
Bak, M., Silahtaroglu, A., Møller, M., Christensen, M., Rath, M. F., Skryabin, B., Tommerup, N., & Kauppinen, S. (2008) · RNA · doi:10.1261/rna.783108 · Cited by 463
Lukiw, W. J., Zhao, Y., & Cui, J. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805371200 · Cited by 441
Research works printed but not linked: 33
- Barbato C., , Ruberti F., , Cogoni C. 2009. Searching for MIND: microRNAs in neurodegenerative diseases. J. Biomed. Biotechnol., 87:1313.
- 10.1682/JRRD.2004.08.0095 · DOI
- 10.1038/nrg2628 · DOI · Paper page
- 10.1002/msj.20101 · DOI
- 10.1097/01.ta.0000233742.75450.47 · DOI
- Cullen D.K., , Browne K.D., , Xu Y., , Adeeb S., , Wolf J.A., , McCarron R.M., , Yang S., , Chavko M., , Smith D.H. 2011. Blast-induced change in photonic crystals corresponds with brain pathology. J. Neurotrauma, 28:2307–2318. · DOI
- 10.1016/j.nurt.2009.10.019 · DOI
- 10.1002/msj.20098 · DOI
- 10.3171/2009.5.PEDS08481 · DOI
- 10.1176/appi.ajp.2007.07071180 · DOI
- 10.1682/JRRD.2006.12.0166 · DOI
- 10.1682/JRRD.2008.08.0100 · DOI
- 10.1007/s00701-009-0463-6 · DOI
- 10.1016/S0960-9822(02)00809-6 · DOI · Paper page
- 10.1373/clinchem.2009.131797 · DOI
- Leung L.Y., , VandeVord P.J., , Dal Cengio A.L., , Bir C., , Yang K.H., , King A.I. 2008. Blast related neurotrauma: a review of cellular injury. Mol. Cell Biomech., 5:155–168.
- 10.1682/JRRD.2005.01.0124 · DOI
- 10.1016/j.cell.2004.12.035 · DOI · Paper page
- 10.1089/neu.2007.0484 · DOI
- 10.1097/CCM.0b013e3181b788ab · DOI
- 10.1093/bioinformatics/btp299 · DOI
- 10.1097/00005373-200012000-00016 · DOI
- 10.1097/01.TA.0000108998.48026.C3 · DOI
- 10.1083/jcb.200810040 · DOI
- 10.1002/jnr.22510 · DOI
- 10.1089/neu.2010.1481 · DOI
- 10.1098/rstb.2010.0230 · DOI · Paper page
- 10.1016/j.exphem.2010.10.004 · DOI
- Stuhmiller J.H., , Phillips Y.Y., , Richmond D.R. 1991. The physics and mechanisms of primary blast injury. Conventional Warfare: Ballistic Blast and Burn Injuries. Zajtchuk R., , Quick C.M. Washington, DC: TMM Publications, 241–270
- 10.1089/neu.2008.0609 · DOI
- Svetlov S.I., , Prima V., , Kirk D.R., , Gutierrez H., , Curley K.C., , Hayes R.L., , Wang K.K. 2010. Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. J. Trauma, 69:795–804.
- 10.1097/CCM.0b013e3181bfeb89 · DOI
- 10.1289/ehp.11841 · DOI
Cited by
Sorted by citations
Ko, J., Hemphill, M., Yang, Z., Sewell, E., Na, Y. J., Sandsmark, D. K., Haber, M., Fisher, S. A., Torre, E. A., Svane, K. C., et al. (2018) · Lab on a Chip · doi:10.1039/c8lc00672e · Cited by 89
Wong, V. S., & Langley, B. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.009 · Cited by 85
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Brindley, E., Heiland, M., Mooney, C., Diviney, M., Mamad, O., Hill, T. D. M., Yan, Y., Venø, M. T., Reschke, C. R., Batool, A., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1230942 · Cited by 21
Metadata
- Authors
- Balakathiresan, N., Bhomia, M., Chandran, R., Chavko, M., McCarron, R. M., & Maheshwari, R. K.
- Affiliations
- Uniformed Services University of the Health Sciences
- Naval Medical Research Center
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2012-05
- Volume
- 29
- Issue
- 7
- Pages
- 1379-1387
- ISSN
- 0897-7151
- 1557-9042
- Cited by
- 119
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
