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Cited by 279

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Effect of Multiple Exposures of Low-Level Laser Therapy on the Cellular Responses of Wounded Human Skin Fibroblasts

Hawkins, Denise, Abrahamse, Heidi·2006·Photomedicine and Laser Surgery
DOI 10.1089/pho.2006.24.705
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Abstract

Objective: This study aimed to establish the behavior of wounded human skin fibroblasts (HSF) after heliumneon(HeNe) (632.8 nm) laser irradiation using one, two, or three exposures of different doses, namely, 2.5, 5.0, or 16.0 J/cm 2 on each day for 2 consecutive days. Background Data: Low-level laser therapy (LLLT) is a form of phototherapy used to promote wound healing in different clinical conditions. LLLT at than adequate wavelength, intensity, and dose can accelerate tissue repair. However, there is still conflicting information about the effect of multiple irradiations on the cellular responses of wounded cells. Methods: Cellular responses to HeNe laser irradiation were evaluated by measuring changes in cell morphology, cell viability, cell proliferation, and damage caused by multiple irradiations. Results: A single dose of 5.0 J/cm 2 , and two or three doses of 2.5 J/cm 2 had a stimulatory or positive effect on wounded fibroblasts with an increase in cell migration and cell proliferation while maintaining cell viability, but without causing additional stress or damage to the cells. Multiple exposures at higher doses (16 J/cm 2 ) caused additional stress, which reduces cell migration, cell viability, and ATP activity, and inhibits cell proliferation. Conclusion: The results show that the correct energy density or fluence (J/cm 2 ) and number of exposures can stimulate cellular responses of wounded fibroblasts and promote cell migration and cell proliferation by stimulating mitochondrial activity and maintaining viability without causing additional stress or damage to the wounded cells. Results indicate that the cumulative effect of lower doses (2.5 or 5 J/cm 2 ) determines the stimulatory effect, while multiple exposures at higher doses (16 J/cm 2 ) result in an inhibitory effect with more damage.

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Metadata

Authors
Hawkins, D., & Abrahamse, H.
Venue
Photomedicine and Laser Surgery
Publisher
SAGE Publications
Published
2006-12
Volume
24
Issue
6
Pages
705-714
ISSN
  • 1549-5418 (ISSN-L)
  • 1557-8550
DOI
10.1089/pho.2006.24.705
OpenAlex
W1969295940
Cited by
279
References
16
FWCI
6.30
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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