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Cited by 45Dermatologic Treatments and ResearchFacial Rejuvenation and Surgery TechniquesSkin Protection and Aging

Combination of Fractional CO 2 Laser and Rhodamine-Intense Pulsed Light in Facial Rejuvenation: A Randomized Controlled Trial

Nistico, Steven Paul, Silvestri, Martina, Zingoni, Tiziano, Tamburi, Federica, Bennardo, Luigi, Cannarozzo, Giovanni·2021·Photobiomodulation Photomedicine and Laser Surgery
DOI 10.1089/photob.2020.4876
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Abstract

Objective: This randomized controlled trial aims to verify the efficacy of a combined fractional CO2 laser and rhodamine-intense pulsed-light (r-IPL) protocol in the photoaging therapy. Background: Skin aging is related to multiple environmental and genetic factors that give rise to different manifestations. In recent years many techniques have been proposed for the rejuvenation of the skin of the face such as ablative and nonablative procedures. Combination of laser or light sources with different wavelengths represents a safe and effective treatment method. r-IPL is a new pulsed-light technique capable to generate wavelengths varying from 550 to 650 nm proposed in nonablative photorejuvenation with a good efficacy and safety profile. Methods: Twenty-two patients (skin phototypes II–III, aged 46–67 years) were randomly allocated into two groups: group A was treated only with a therapeutic standard dose of the fractional CO2 laser, whereas group B was treated with a combined therapy of r-IPL and fractional CO2 laser. All patients were treated up to three times at a 2-month interval. Efficacy of the procedures was assessed thanks to the Fitzpatrick Wrinkle Severity Scale (scores 1–9) before treatment and at a 4-month follow-up from the last treatment. Results: Patients treated with the combination of r-IPL and fractional CO2 laser showed better results in terms of wrinkle reduction according to the Fitzpatrick Wrinkle Severity score (2.82 ± 0.87 vs. 3.09 ± 1.14), with a statistically significant reduction in healing times (7.82 ± 0.75 vs. 13.82 ± 1.94 days, p ≤ 0.001) and duration of post-treatment erythema (3.55 ± 0.93 vs. 8.18 ± 1.47 days, p ≤ 0.001). Patient satisfaction was higher after combined fractional CO2 laser and r-IPL treatment. Conclusions: Our data suggest that combined use of fractional CO2 laser and r-IPL may lead to excellent results in terms of skin rejuvenation with a simple post-treatment management and an optimal tolerability.

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  • Histological and ultrastructural studies show epidermal hyperplasia, damage and disorder of collagen fibers, and accumulation of abnormal elastic substances in connective tissue in photoaged skin.

    “Histological and ultrastructural studies have shown epidermal hyperplasia, damage, and disorder of collagen fibers, and a large accumulation of abnormal elastic substances in connective tissue in photoaged skin [32,33].”

    From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [33]

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Authors
Nistico, S. P., Silvestri, M., Zingoni, T., Tamburi, F., Bennardo, L., & Cannarozzo, G.
Affiliations
  • Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
  • Magna Graecia University (IT)
  • University of Rome Tor Vergata (IT)
Corresponding author
Bennardo, Luigi
ORCID
Venue
Photobiomodulation Photomedicine and Laser Surgery
Publisher
SAGE Publications
Published
2021-02-01
Volume
39
Issue
2
Pages
113-117
ISSN
2578-5478 (ISSN-L)
DOI
10.1089/photob.2020.4876
OpenAlex
W3125680036
Cited by
45
References
17
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 16 · 2021: 12
FWCI
9.10
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Photobiomodulation Photomedicine and Laser Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
fractional CO2 laser, facial rejuvenation, photoaging, wrinkle reduction, combination therapy, healing time, patient satisfaction
MeSH terms
Carbon Dioxide, Humans, Rejuvenation, Rhodamines, Skin Aging, Lasers, Gas

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