The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Vascularization—The Conduit to Viable Engineered Tissues
Abstract
Long-term viability of thick three-dimensional engineered tissue constructs is a major challenge. Addressing it requires development of vessel-like network that will allow the survival of the construct in vitro and its integration in vivo owing to improved vascularization after implantation. Resulting from work of various research groups, several approaches were developed aiming engineered tissue vascularization: (1) embodiment of angiogenesis growth factors in the polymeric scaffolds for prolonged release, (2) coculture of endothelial cells with target tissue cells and angiogenesis signaling cells, (3) use of microfabrication methods for creating designed channels for allowing nutrients to flow and/or for directing endothelial cells attachment, and (4) decellularization of organs and blood vessels for creating extracellular matrix. A synergistic effect is expected by combining several of these approaches as already demonstrated in some of the latest studies. Current paper reviews the progress in each approach and recent achievements toward vascularization of engineered tissues.
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1 retracted
Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
Lee, H. C., Kim, S.-J., Kim, K.-S., Shin, H.-C., & Yoon, J.-W. (2000) · Nature · doi:10.1038/35044106 · Cited by 434
RetractedThe biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Asahara, T., Masuda, H., Takahashi, T., Kalka, C., Pastore, C., Silver, M., Kearne, M., Magner, M., & Isner, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.3.221 · Cited by 3,253
Folkman, J., & Shing, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49853-0 · Cited by 2,654
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650
Molecular regulation of vessel maturation
Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,529
Polymeric system for dual growth factor delivery
Richardson, T. P., Peters, M. C., Ennett, A. B., & Mooney, D. J. (2001) · Nature Biotechnology · doi:10.1038/nbt1101-1029 · Cited by 1,752
Cited by
Bioprinting for vascular and vascularized tissue biofabrication
Datta, P., Ayan, B., & Ozbolat, I. T. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.035 · Cited by 431
Zhao, X., Liu, S., Yildirimer, L., Zhao, H., Ding, R., Wang, H., Cui, W., & Weitz, D. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504943 · Cited by 426
Vascularized Bone Tissue Engineering: Approaches for Potential Improvement
Nguyen, L. H., Annabi, N., Nikkhah, M., Bae, H., Binan, L., Park, S., Kang, Y., Yang, Y., & Khademhosseini, A. (2012) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2012.0012 · Cited by 313
Microfluidic techniques for development of 3D vascularized tissue
Hasan, A., Paul, A., Vrana, N. E., Zhao, X., Memic, A., Hwang, Y.-S., Dokmeci, M. R., & Khademhosseini, A. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.091 · Cited by 282
A multilayered microfluidic blood vessel-like structure
Hasan, A., Paul, A., Memic, A., & Khademhosseini, A. (2015) · Biomedical Microdevices · doi:10.1007/s10544-015-9993-2 · Cited by 139
Metadata
- Authors
- Kaully, T., Kaufman-Francis, K., Lesman, A., & Levenberg, S.
- Venue
- Tissue Engineering Part B: Reviews
- Publisher
- SAGE Publications
- Published
- 2009-06
- Volume
- 15
- Issue
- 2
- Pages
- 159-169
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W2007335169
- Cited by
- 317
- References
- 75
- FWCI
- 20.30
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
