A multilayered microfluidic blood vessel-like structure
Open accessAbstract
There is an immense need for tissue engineered blood vessels. However, current tissue engineering approaches still lack the ability to build native blood vessel-like perfusable structures with multi-layered vascular walls. This paper demonstrated a new method to fabricate tri-layer biomimetic blood vessel-like structures on a microfluidic platform using photocrosslinkable gelatin hydrogel. The presented method enables fabrication of physiological blood vessel-like structures with mono-, bi- or tri-layer vascular walls. The diameter of the vessels, the total thickness of the vessel wall and the thickness of each individual layer of the wall were independently controlled. The developed fabrication process is a simple and rapid method, allowing the physical fabrication of the vascular structure in minutes, and the formation of a vascular endothelial cell layer inside the vessels in 3-5 days. The fabricated vascular constructs can potentially be used in numerous applications including drug screening, development of in vitro models for cardiovascular diseases and/or cancer metastasis, and study of vascular biology and mechanobiology.
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- Authors
- Hasan, A., Paul, A., Memic, A., & Khademhosseini, A.
- Affiliations
- American University of Beirut (LB)
- Brigham and Women's Hospital (US)
- Corresponding author
- Hasan, Anwarul
- Khademhosseini, Ali
- Venue
- Biomedical Microdevices
- Published
- 2015-08-11
- Volume
- 17
- Issue
- 5
- Pages
- 88-88
- ISSN
- 1387-2176 (ISSN-L)
- 1572-8781
- PMC
- PMC4890640
- OpenAlex
- W1436031433
- Cited by
- 139
- References
- 41
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 13 · 2023: 21 · 2022: 15 · 2021: 17 · 2020: 9 · 2019: 13 · 2018: 18 · 2017: 15 · 2016: 9
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomedical Microdevices (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- KU ScholarWorks (The University of Kansas) (submittedVersion)
- Springer US
- Funders
- National Heart, Lung, and Blood Institute (HL-099073, R01HL099073)
- National Institute of General Medical Sciences (P20GM103638)
- National Institute of Allergy and Infectious Diseases (R56AI105024, AI105024)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057837, R01AR057837, R56AR063745, AR063745)
- National Institute of Biomedical Imaging and Bioengineering (R01EB012597, EB012597)
- National Institute of Dental and Craniofacial Research (DE021468, R01DE021468)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- tissue-engineered blood vessels, drug screening, cardiovascular disease models, mechanobiology
- MeSH terms
- Blood Vessel Prosthesis, Cells, Cultured, Equipment Design, Humans, Miniaturization, Equipment Failure Analysis, Tissue Engineering, Biomimetic Materials, Endothelial Cells, Microfluidics, Tissue Scaffolds, Printing, Three-Dimensional
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