The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Cytoskeletal and Focal Adhesion Influences on Mesenchymal Stem Cell Shape, Mechanical Properties, and Differentiation Down Osteogenic, Adipogenic, and Chondrogenic Pathways
Open accessAbstract
Mesenchymal stem cells (MSCs) hold great potential for regenerative medicine and tissue-engineering applications. They have multipotent differentiation capabilities and have been shown to differentiate down various lineages, including osteoblasts, adipocytes, chondrocytes, myocytes, and possibly neurons. The majority of approaches to control the MSC fate have been via the use of chemical factors in the form of growth factors within the culture medium. More recently, it has been understood that mechanical forces play a significant role in regulating MSC fate. We and others have shown that mechanical stimuli can control MSC lineage specification. The cytoskeleton is known to play a large role in mechanotransduction, and a growing number of studies are showing that it can also contribute to MSC differentiation. This review analyzes the significant contribution of actin and integrin distribution, and the smaller role of microtubules, in regulating MSC fate. Osteogenic differentiation is more prevalent in MSCs with a stiff, spread actin cytoskeleton and greater numbers of focal adhesions. Both adipogenic differentiation and chondrogenic differentiation are encouraged when MSCs have a spherical morphology associated with a dispersed actin cytoskeleton with few focal adhesions. Different mechanical stimuli can be implemented to alter these cytoskeletal patterns and encourage MSC differentiation to the desired lineage.
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Cited by
Winkler, T., Sass, F. A., Duda, G. N., & Schmidt-Bleek, K. (2018) · Bone & Joint Research · doi:10.1302/2046-3758.73.bjr-2017-0270.r1 · Cited by 482
Biopolymer-based functional composites for medical applications
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Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?
Oryan, A., Kamali, A., Moshiri, A., & Baghaban Eslaminejad, M. (2017) · Cells Tissues Organs · doi:10.1159/000469704 · Cited by 353
The Evolution of Polystyrene as a Cell Culture Material
Lerman, M. J., Lembong, J., Muramoto, S., Gillen, G., & Fisher, J. P. (2018) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2018.0056 · Cited by 258
Mesenchymal stem cells: mechanisms and role in bone regeneration
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Metadata
- Authors
- Mathieu, P. S., & Loboa, E. G.
- Venue
- Tissue Engineering Part B: Reviews
- Publisher
- SAGE Publications
- Published
- 2012-12
- Volume
- 18
- Issue
- 6
- Pages
- 436-444
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W2060451182
- Cited by
- 379
- References
- 57
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Mathieu, P. S., & Loboa, E. G. (2012). Cytoskeletal and Focal Adhesion Influences on Mesenchymal Stem Cell Shape, Mechanical Properties, and Differentiation Down Osteogenic, Adipogenic, and Chondrogenic Pathways. Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.teb.2012.0014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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