The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
Umbilical Cord Mesenchymal Stem Cells: The New Gold Standard for Mesenchymal Stem Cell-Based Therapies?
Open accessAbstract
Due to their self-renewal capacity, multilineage differentiation potential, paracrine effects, and immunosuppressive properties, mesenchymal stromal cells (MSCs) are an attractive and promising tool for regenerative medicine. MSCs can be isolated from various tissues but despite their common immunophenotypic characteristics and functional properties, source-dependent differences in MSCs properties have recently emerged and lead to different clinical applications. Considered for a long time as a medical waste, umbilical cord appears these days as a promising source of MSCs. Several reports have shown that umbilical cord-derived MSCs are more primitive, proliferative, and immunosuppressive than their adult counterparts. In this review, we aim at synthesizing the differences between umbilical cord MSCs and MSCs from other sources (bone marrow, adipose tissue, periodontal ligament, dental pulp,…) with regard to their proliferation capacity, proteic and transcriptomic profiles, and their secretome involved in their regenerative, homing, and immunomodulatory capacities. Although umbilical cord MSCs are until now not particularly used as an MSC source in clinical practice, accumulating evidence shows that they may have a therapeutic advantage to treat several diseases, especially autoimmune and neurodegenerative diseases.
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Cites
2 retracted
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RetractedHuman mesenchymal stem cells modulate allogeneic immune cell responses
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Mesenchymal stem cells in health and disease
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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
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Matrix Metalloproteinases: A Review
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Innate or adaptive immunity? The example of natural killer cells
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Cited by
Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment
Whiteside, T. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2017.12.003 · Cited by 308
Human Adipose Stem Cells: From Bench to Bedside
De Francesco, F., Ricci, G., D'Andrea, F., Nicoletti, G. F., & Ferraro, G. A. (2015) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2014.0608 · Cited by 163
Liu, W., Liu, A., Li, X., Sun, Z., Sun, Z., Liu, Y., Wang, G., Huang, D., Xiong, H., Yu, S., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.06.012 · Cited by 107
Todeschi, M. R., El Backly, R., Capelli, C., Daga, A., Patrone, E., Introna, M., Cancedda, R., & Mastrogiacomo, M. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0490 · Cited by 103
BULUT, Ö., & GÜRSEL, İ. (2020) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-2002-79 · Cited by 34
Metadata
- Authors
- El Omar, R., Beroud, J., Stoltz, J.-F., Menu, P., Velot, E., & Decot, V.
- Venue
- Tissue Engineering Part B: Reviews
- Publisher
- SAGE Publications
- Published
- 2014-10
- Volume
- 20
- Issue
- 5
- Pages
- 523-544
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W198903736
- Cited by
- 330
- References
- 168
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- green
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- El Omar, R., Beroud, J., Stoltz, J.-F., Menu, P., Velot, E., & Decot, V. (2014). Umbilical Cord Mesenchymal Stem Cells: The New Gold Standard for Mesenchymal Stem Cell-Based Therapies? Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.teb.2013.0664
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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