Thyroid Function and Left Ventricular Structure and Function in the Framingham Heart Study
Open accessAbstract
BACKGROUND: Thyroid hormone acts on the heart and peripheral vasculature in multiple ways. Even in patients with subclinical hypo- or hyperthyroidism, subclinical alterations in left ventricular (LV) structure and function may be associated with important clinical effects. Our objective was to determine whether thyroid function is related to echocardiographic indices of LV structure and function. METHODS: Cross-sectional association of serum thyroid-stimulating hormone (TSH) with two-dimensional-guided M-mode echo LV dimensions and function. Participants were 1376 Framingham Heart Study participants (61% women, mean age 69 years) who attended a routine examination 1979-1981. We excluded participants with myocardial infarction or heart failure, renal insufficiency, and missing data, and those using thyroid hormone or antithyroid medications. Serum TSH was measured 1977-1979. The following echocardiographic measurements were analyzed both as continuous variables and dichotomized at the top quintile: LV end-diastolic dimensions, LV wall thickness, LV mass, LV fractional shortening (an indicator of systolic function), and left atrial diameter. Sex-specific multiple regression models were adjusted for age, height, weight, blood pressure, heart rate, total to high-density lipoprotein cholesterol ratio, and the presence of diabetes, hypertension treatment, and valve disease. RESULTS: In multivariable linear models, log-TSH was not related to LV mass, LV wall thickness, or left atrial size in either sex, or to LV systolic function in men. Log-TSH had a borderline inverse association with fractional shortening (p = 0.06) in women. In multivariable logistic models, women with TSH <0.5 mU/L (n = 81) had a greater odds of being in the highest quintile of fractional shortening compared to euthyroid subjects (odds ratio 2.2, 95% confidence interval 1.3-3.8, p = 0.01). CONCLUSIONS: In our moderate-sized community-based sample, TSH concentration was not associated with LV structure in either sex, but was inversely related to LV contractility, consistent with the known inotropic effects of thyroid hormone.
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Two recent prospective studies did not find a link between subclinical hyperthyroidism and left ventricular mass in elderly subjects.
“On the other hand, two recent prospective studies did not find a link between SHyper and left ventricular mass in elderly subjects [69,70] , almost certainly because SHyper has not been associated with symptoms of adrenergic overactivity in the elderly [50] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [69]
Cites
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430 · see citing works
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.489 · Cited by 4,279 · see citing works
Thyroid hormone and the cardiovascular system.
Klein, I., & Ojamaa, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440707 · Cited by 2,300 · see citing works
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148 · see citing works
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418 · see citing works
Low Serum Thyrotropin Concentrations as a Risk Factor for Atrial Fibrillation in Older Persons
Sawin, C. T., Geller, A., Wolf, P. A., Belanger, A. J., Baker, E., Bacharach, P., Wilson, P., Benjamin, E. J., & D'Agostino, R. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411103311901 · Cited by 1,259 · cited 1× · see citing works
“It has been shown clearly, however, that patients with both overt and subclinical hyperthyroidism are at increased risk for atrial fibrillation (10).”
Self-citationEffects of Subclinical Thyroid Dysfunction on the Heart
Biondi, B., Palmieri, E. A., Lombardi, G., & Fazio, S. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-11-200212030-00011 · Cited by 443 · see citing works
The aging thyroid. Thyroid deficiency in the Framingham Study
Sawin, C. T. (1985) · Archives of Internal Medicine · doi:10.1001/archinte.145.8.1386 · Cited by 413 · see citing works
Biondi, B. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4701 · Cited by 356 · see citing works
Left Ventricular Diastolic Dysfunction in Patients with Subclinical Hypothyroidism
Biondi, B., Fazio, S., Palmieri, E. A., Carella, C., Panza, N., Cittadini, A., Bonè, F., Lombardi, G., & Saccà, L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5733 · Cited by 334 · see citing works
Staub, J.-J., Althaus, B., Engler, H., Ryff, A., Trabucco, P., Marquardt, K., BURCKHARDT, D., Girard, J., & Weintraub, B. D. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90782-7 · Cited by 317 · see citing works
Cardiovascular and Atherogenic Aspects of Subclinical Hypothyroidism
Kahaly, G. J. (2000) · Thyroid · doi:10.1089/10507250050137743 · Cited by 310 · see citing works
Monzani, F., Di Bello, V., Caraccio, N., Bertini, A., Giorgi, D., Giusti, C., & Ferrannini, E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7291 · Cited by 308 · see citing works
Biondi, B., Palmieri, E. A., Lombardi, G., & Fazio, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8302 · Cited by 245 · see citing works
Noninvasive Evaluation of Cardiac Function in Hypothyroidism
Crowley, W. F., Ridgway, E. C., Bough, E. W., Francis, G. S., Daniels, G. H., KOURIDES, I. A., Myers, G. S., & Maloof, F. (1977) · New England Journal of Medicine · doi:10.1056/nejm197701062960101 · Cited by 238 · see citing works
Cardiac effects of long term thyrotropin-suppressive therapy with levothyroxine.
Biondi, B., Fazio, S., Carella, C., Amato, G., Cittadini, A., Lupoli, G., Saccà, L., Bellastella, A., & Lombardi, G. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.2.8345037 · Cited by 237 · see citing works
Sgarbi, J. A., Villaça, F. G., Garbeline, B., Villar, H. E., & Romaldini, J. H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021046 · Cited by 177 · see citing works
Mercuro, G. G., Panzuto, M., Bina, A., Leo, M., Cabula, R., Petrini, L., Pigliaru, F., & Mariotti, S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6298 · Cited by 162 · see citing works
Does subclinical hypothyroidism affect cardiac pump performance?
Ripoli, A., Pingitore, A., Favilli, B., Bottoni, A., Turchi, S., Osman, N. F., De Marchi, D., Lombardi, M., L'Abbate, A., & Iervasi, G. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.10.044 · Cited by 157 · see citing works
Mintz, G. L., Pizzarello, R. A., & Klein, I. L. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-146 · Cited by 156 · see citing works
Hypothyroidism and dyslipidemia: Modern concepts and approaches
Pearce, E. N. (2004) · Current Cardiology Reports · doi:10.1007/s11886-004-0054-3 · Cited by 153 · see citing works
Self-citationBengel, F. M., Nekolla, S. G., Ibrahim, T., Weniger, C., Ziegler, S. I., & Schwaiger, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.5.6520 · Cited by 153 · see citing works
The Association of Thyroid Function with Cardiac Mass and Left Ventricular Hypertrophy
Dörr, M., Wolff, B., Robinson, D. M., John, U., Lüdemann, J., Meng, W., Felix, S. B., & Völzke, H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1554 · Cited by 140 · see citing works
Cardiac effects of long term thyrotropin-suppressive therapy with levothyroxine
Biondi, B. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.2.334 · Cited by 133 · see citing works
Brenta, G., Mutti, L. A., Schnitman, M., Fretes, O., Perrone, A., & Matute, M. L. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00322-9 · Cited by 118 · see citing works
Subclinical Hypothyroidism, Arterial Stiffness, and Myocardial Reserve
Owen, P., Rajiv, C., Vinereanu, D., Mathew, T., Fraser, A. G., & Lazarus, J. H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2108 · Cited by 110 · see citing works
Shapiro, L. E., Sievert, R., Ong, L., Ocampo, E. L., Chance, R. A., Lee, M., Nanna, M., Ferrick, K. J., & Surks, M. I. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4155 · Cited by 109 · see citing works
Feldman, T. E., Borow, K. M., Sarne, D. H., Neumann, A., & Lang, R. M. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80213-3 · Cited by 106 · see citing works
Cardiovascular Effects of Mild Hypothyroidism
Biondi, B. (2007) · Thyroid · doi:10.1089/thy.2007.0158 · Cited by 106 · see citing works
Vitale, G., Galderisi, M., Lupoli, G., Celentano, A., Pietropaolo, I., Parenti, N., DIVITIIS, O. D., & Lupoli, G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-011764 · Cited by 100 · see citing works
Yazici, M., Gorgulu, S., Sertbas, Y., Erbilen, E., Albayrak, S., Yildiz, O., & Uyan, C. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2003.05.015 · Cited by 99 · see citing works
Arem, R., Rokey, R., Kiefe, C. I., Escalante, D. A., & Rodríguez, A. (1996) · Thyroid · doi:10.1089/thy.1996.6.397 · Cited by 88 · see citing works
Shapiro, L. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2592 · Cited by 76 · see citing works
Hyperthyroidism and Cardiovascular Morbidity and Mortality
Osman, F., GAMMAGE, M. D., & Franklyn, J. A. (2002) · Thyroid · doi:10.1089/105072502760143854 · Cited by 74 · see citing works
High-density lipoprotein cholesterol and left ventricular hypertrophy in essential hypertension
Schillaci, G., Vaudo, G., Reboldi, G., Verdecchia, P., Lupattelli, G., Pasqualini, L., Porcellati, C., & Mannarino, E. (2001) · Journal of Hypertension · doi:10.1097/00004872-200112000-00021 · Cited by 58 · see citing works
Effect of l-thyroxine treatment on left ventricular function in subclinical hypothyroidism
Franzoni, F., Galetta, F., Fallahi, P., Tocchini, L., Merico, G., Braccini, L., Rossi, M., Carpi, A., Antonelli, A., & Santoro, G. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.010 · Cited by 39 · see citing works
Földes, J., Istvánffy, M., Halmágyi, M., Váradi, A., Gara, A., & Pártos, O. (1987) · PubMed · Cited by 39 · see citing works
Biondi, B., Fazio, S., Palmieri, E. A., Tremalaterra, R., Angellotti, G., Bonè, F., Riccio, G., Cittadini, A., Lombardi, G., & Saccà, L. (1999) · PubMed · Cited by 38 · see citing works
Kahaly, G. J., Mohr-Kahaly, S., Beyer, J. ̈., & Meyer, J. ̈. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80641-9 · Cited by 37 · see citing works
Subclinical Thyrotoxicosis and the Heart
Burmeister, L., & Flores, A. (2002) · Thyroid · doi:10.1089/105072502760143872 · Cited by 26 · see citing works
Flagged first, then by citations
3 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cooper, D. S., & Biondi, B. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60276-6 · Cited by 1,039 · see citing works
Thyroid hormones and cardiovascular disease
Jabbar, A., Pingitore, A., Pearce, S. H. S., Zaman, A., Iervasi, G., & Razvi, S. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.174 · Cited by 729 · see citing works
Biondi, B., Bartalena, L., Cooper, D. S., Hegedüs, L., Laurberg, P., & Kahaly, G. J. (2015) · European Thyroid Journal · doi:10.1159/000438750 · Cited by 323 · see citing works
Effects of thyroid hormones on the heart
Vargas‐Uricoechea, H., Bonelo, A., & Sierra-Torres, C. H. (2014) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2014.07.003 · Cited by 193 · see citing works
Thyroid Disease and the Cardiovascular System
Danzi, S. E., & Klein, I. L. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.02.005 · Cited by 160 · see citing works
Clinical practice guidelines for the management of hypothyroidism
Brenta, G., Vaisman, M., Sgarbi, J. A., Bergoglio, L., de Andrada, N. C., Bravo, P. P., Orlandi, A. M., & Graf, H. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000400003 · Cited by 161 · see citing works
Khan, R., Sikanderkhel, S., Gui, J., Adeniyi, A.-R., O’Dell, K., Erickson, M., Malpartida, J. C., Mufti, Z., Khan, T., Mufti, H., et al. (2020) · Cardiology Research · doi:10.14740/cr1034 · Cited by 80 · see citing works
Thyroid hormones and the heart
Vargas‐Uricoechea, H., & Sierra-Torres, C. H. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0059 · Cited by 65 · see citing works
Thyroid Status, Cardiac Function, and Mortality in Patients With Idiopathic Dilated Cardiomyopathy
Wang, W., Guan, H., Gerdes, A. M., Iervasi, G., Yang, Y., & Tang, Y. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4159 · Cited by 60 · see citing works
Yang, L.-B., Jiang, D.-Q., Qi, W.-B., Zhang, T., Feng, Y.-L., Gao, L., & Zhao, J. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0015 · Cited by 56 · see citing works
Sgarbi, J. A., Teixeira, P. D. F. D. S., Maciel, L. M. Z., Mazeto, G. M. F. D. S., Vaisman, M., Montenegro, R. M., & Ward, L. S. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000300003 · Cited by 56 · see citing works
Franklyn, J. A. (2012) · Clinical Endocrinology · doi:10.1111/cen.12011 · Cited by 47 · see citing works
Roef, G. L., Taes, Y., Kaufman, J., daele, C. M. V., Buyzere, M. D., Gillebert, T. C., & Rietzschel, E. R. (2013) · Thyroid · doi:10.1089/thy.2012.0471 · Cited by 41 · see citing works
Metabolomic Signatures of Cardiac Remodelling and Heart Failure Risk in the Community
Andersson, C., Liu, C., Cheng, S. C., Wang, T. J., Gerszten, R. E., Larson, M. G., & Vasan, R. S. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12923 · Cited by 38 · see citing works
Self-citationSert, A., Pirgon, Ö., Aypar, E., Yılmaz, H. S., & Odabaş, D. (2013) · Pediatric Cardiology · doi:10.1007/s00246-013-0638-z · Cited by 33 · see citing works
Determinants of Thyrotoxic Cardiomyopathy Recovery
Oliveros-Ruiz, M. L., Vallejo, M., Canseco, L. F. D., Cárdenas, M., & Hermosillo, J. A. G. (2013) · BioMed Research International · doi:10.1155/2013/452709 · Cited by 32 · see citing works
Subclinical hypothyroidism and myocardial function in obese children
Brienza, C., Grandone, A., Salvo, G. D., Corona, A. M., Sessa, A. D., Pascotto, C., Calabrò, R., Toraldo, R., Perrone, L., & del Giudice, E. M. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.04.006 · Cited by 30 · see citing works
Should we treat mild subclinical/mild hyperthyroidism? Yes
Wiersinga, W. M. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.03.008 · Cited by 27 · see citing works
Traub‐Weidinger, T., Graf, S., Beheshti, M., Ofluoglu, S., Zettinig, G., Khorsand, A., Nekolla, S. G., Kletter, K., Dudczak, R., & Pirich, C. (2012) · Thyroid · doi:10.1089/thy.2011.0183 · Cited by 27 · see citing works
Seara, F. D. A. C., Maciel, L., Barbosa, R. A. Q., Rodrigues, N. C., da Silveira, A. L. B., Marassi, M. P., Carvalho, A. B., Nascimento, J. H. M., & Olivares, E. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190355 · Cited by 26 · see citing works
Vis, J. C., de Bruin‐Bon, R. H. A. C. M., Bouma, B. J., Backx, A., Huisman, S. A., Imschoot, L., & Mulder, B. J. M. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.01.064 · Cited by 25 · see citing works
Should we treat mild subclinical/mild hyperthyroidism? No
Vanderpump, M. P. J. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.03.009 · Cited by 25 · see citing works
Neves, J. S., Fontes‐Carvalho, R., Borges‐Canha, M., Leite, A. R., Martins, S., Oliveira, A. B. F. D., Guimarães, J. T., Carvalho, D. M., Leite-Moreira, A. F., & Azevedo, A. (2020) · European Thyroid Journal · doi:10.1159/000508407 · Cited by 26 · see citing works
Neves, J. S., Vale, C., von Hafe, M., Borges‐Canha, M., Leite, A. R., Almeida‐Coelho, J., Lourenço, A. P., Falcão‐Pires, I., Carvalho, D. M., & Leite-Moreira, A. F. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820958331 · Cited by 24 · see citing works
Taillard, V., Sardinoux, M., Oudot, C., Fesler, P., Rugale, C., Raingeard, I., Renard, É., Ribstein, J., & du Cailar, G. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04138.x · Cited by 22 · see citing works
Level of Physical Activity, Left Ventricular Mass, Hypertension, and Prognosis
Joseph, G., Marott, J. L., Biering‐Sørensen, T., Johansen, M. B., Saevereid, H. A., Nielsen, G. N., Schnohr, P., Prescott, E., Søgaard, P., & Møgelvang, R. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.14287 · Cited by 21 · see citing works
Iida, M., 山本, 充., Ishiguro, Y., Yamazaki, M., Honjo, H., & Kamiya, K. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.04.002 · Cited by 20 · see citing works
Hyperglycemia Has a Greater Impact on Left Ventricle Function in South Asians Than in Europeans
Park, C. M., Tillin, T., March, K., Ghosh, A. K., Jones, S. H., Wright, A., Heasman, J., Francis, D. P., Sattar, N. A., Mayet, J., et al. (2013) · Diabetes Care · doi:10.2337/dc13-1864 · Cited by 20 · see citing works
Subclinical Hypothyroidism and Cardiovascular Risk
Weiss, I. A., Bloomgarden, N. A., & Frishman, W. H. (2011) · Cardiology in Review · doi:10.1097/crd.0b013e318227df87 · Cited by 20 · see citing works
Casis, Ó., Echeazarra, L., Sáenz-Díez, B., & Gallego, M. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-01000-z · Cited by 20 · see citing works
Evaluation of left ventricular systolic asynchrony in patients with subclinical hypothyroidism
Öztürk, S., Alçelik, A., Özyaşar, M., Dikbaş, O., Ayhan, S., Özlü, F., Erdem, A., Tosun, M., Baltacı, D., & Yazıcı, M. (2012) · Cardiology Journal · doi:10.5603/cj.2012.0068 · Cited by 18 · see citing works
Çatlı, G., Kır, M., Anık, A., Yılmaz, N., Böber, E., & Abacı, A. (2014) · Archives of Disease in Childhood · doi:10.1136/archdischild-2014-306381 · Cited by 18 · see citing works
Aroditis, K., Pikilidou, M. I., Vourvouri, E. C., Hadjistavri, L., Zebekakis, P. E., Yovos, J. G., Efthimiadis, G. K., & Karvounis, H. I. (2016) · International journal of cardiac imaging · doi:10.1007/s10554-016-0984-z · Cited by 17 · see citing works
Subclinical Hyperthyroidism and Cardiovascular Disease
Kim, H. J., & McLeod, D. S. A. (2024) · Thyroid · doi:10.1089/thy.2024.0291 · Cited by 15 · see citing works
Graves’ disease, multinodular goiter and subclinical hyperthyroidism
Lassen, P. B., Kyrilli, A., Lytrivi, M., & Corvilain, B. (2018) · Annales d Endocrinologie · doi:10.1016/j.ando.2018.09.004 · Cited by 15 · see citing works
Childhood thyroid function, body composition and cardiovascular function
Barjaktarovic, M., Korevaar, T. I. M., Gaillard, R., de Rijke, Y. B., Visser, T. J., Jaddoe, V. W. V., & Peeters, R. P. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0369 · Cited by 14 · see citing works
Azak, E., Uçaktürk, S. A., Çetin, İ. İ., Gürsu, H. A., Mengen, E., & Pamuk, U. (2019) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2019.2018.0273 · Cited by 13 · see citing works
Öztürk, S., Dikbaş, O., Baltacı, D., Özyaşar, M., Erdem, A., Ayhan, S. S., Özlü, F., Alçelik, A., Tosun, M., & Yazıcı, M. (2012) · PubMed · Cited by 13 · see citing works
Chou, K.-M., Chiu, S. Y., Chen, C.-H., Yang, N., Huang, B.-Y., & Sun, C. (2011) · Kidney & Blood Pressure Research · doi:10.1159/000328324 · Cited by 12 · see citing works
Barasch, E., Gottdiener, J. S., Bůžková, P., Cappola, A. R., Shah, S. J., deFilippi, C. R., Gardin, J. M., & Kizer, J. R. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae001 · Cited by 11 · see citing works
Pandrc, M. S., Ristić, A., Kostovski, V., Milin-Lazovic, J. S., & Ćirić, J. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14577 · Cited by 11 · see citing works
Li, M., Ke, J.-F., Li, S., Wang, J., Zhu, Z.-H., & Li, J. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00760-2 · Cited by 11 · see citing works
Enfermedades sistémicas y corazón: introducción
de Isla, L. P., y, P. A., Bayés‐Genís, A., Sanchís, J. M., & Heras, M. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2010.10.005 · Cited by 10 · see citing works
Liu, G., Ren, M., Du, Y., Zhao, R., Wu, Y. F., Liu, Y., & Liang, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1263861 · Cited by 10 · see citing works
Echocardiographic Evaluation of Cardiac Function in Female Patients with Thyroid Disorders
Hadžović-Džuvo, A., Kučukalić-Selimović, E., Nakaš-Ićindić, E., Rašić, S., Begić, A., Tawil, D. A., Valjevac, A., Avdagić, N., & Lepara, O. (2010) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2010.2704 · Cited by 10 · see citing works
Li, X., Yao, Y., Chen, Z., Fan, S., Hua, W., Zhang, S., & Fan, X. (2018) · Clinical Cardiology · doi:10.1002/clc.23117 · Cited by 10 · see citing works
Ylli, D., Kłubo-Gwieździńska, J., & Wartofsky, L. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-33376-8_6 · Cited by 9 · see citing works
Systemic Diseases and the Cardiovascular System: Introduction
de Isla, L. P., y, P. A., Bayés‐Genís, A., Sanchís, J. M., & Heras, M. (2010) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2010.10.007 · Cited by 8 · see citing works
Abdelrazk, R. R., El‐Sehrawy, A. A. M. A., Ghoniem, M. G. M., & Amer, M. Z. (2020) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000241 · Cited by 8 · see citing works
Solanki, K., Al-Majmuei, M., & White, D. (2018) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000703 · Cited by 8 · see citing works
Subclinical Hyperthyroidism and Cardiovascular Risk
Palmeiro, C., Davila, M. I., Bhat, M., Frishman, W. H., & Weiss, I. A. (2013) · Cardiology in Review · doi:10.1097/crd.0b013e318294f6f1 · Cited by 7 · see citing works
Evaluation of Patients with Heart Failure
Patarroyo‐Aponte, M., & Colvin, M. M. (2013) · Cardiology Clinics · doi:10.1016/j.ccl.2013.09.014 · Cited by 7 · see citing works
Prado-Uribe, M. D. C., Ventura, M.-D.-J., Ávila–Díaz, M., Mora, C. J., Méndez-Durán, A., Villanueva-Noches, D., Cisneros, A., Ilabaca, B., Cueto-Manzano, A. M., García-Contreras, F., et al. (2017) · Nefrología · doi:10.1016/j.nefro.2017.05.015 · Cited by 6 · see citing works
Kłubo-Gwieździńska, J., Bernet, V. J., & Wartofsky, L. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-314-5_6 · Cited by 6 · see citing works
Assessment of left atrial mechanical functions in thyroid dysfunction
Karabağ, T., Doğan, S. M., Bayraktaroğlu, T., Sayın, M. R., Büyükuysal, Ç., Akpınar, İ., & Aydın, M. (2013) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1970 · Cited by 6 · see citing works
Comorbidities of Thyroid Disease in Children
Pimentel, J. L., Chambers, M. A., Shahid, M., Chawla, R., & KAPADIA, C. R. (2016) · Advances in Pediatrics · doi:10.1016/j.yapd.2016.04.016 · Cited by 6 · see citing works
The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study
Liu, J., Wu, G., Li, S., Cheng, L., & Ye, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1344282 · Cited by 4 · see citing works
Endogenous subclinical hyperthyroidism: who, when and why to treat
Biondi, B. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.69 · Cited by 4 · see citing works
Zhang, H., Zhang, J., Li, H., Bi, Y., Wang, L., & Li, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.906947 · Cited by 3 · see citing works
Nakova, V. V. (2014) · Journal of Thyroid Disorders & Therapy · doi:10.4172/2167-7948.1000177 · Cited by 3 · see citing works
The Relevance of Serum Cystatin C Level of Different Classification of Atrial Fibrillation
Duan, Y., Xu, J.-H., Hu, W., Li, P., & Li, R. (2019) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2019.108033 · Cited by 3 · see citing works
Zandieh, S., Schuck, L., Mirzaei, S., Haller, J., Hergan, K., & Bernt, R. (2017) · Journal of Thoracic Imaging · doi:10.1097/rti.0000000000000306 · Cited by 3 · see citing works
Assessing cardiovascular changes in Iraqi women with hypothyroidism
Ghazi, S. M., Salman, A. A., & Jawad, A. A. (2023) · Journal of Medicine and Life · doi:10.25122/jml-2022-0220 · Cited by 2 · see citing works
Thyroid Hormones and Cardiovascular Surgery
Gabriel, E. A., & Gabriel, S. A. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4429-8_31 · Cited by 2 · see citing works
Barachini, O., Schaer, M., Mirzaei, S., Hergan, K., & Zandieh, S. (2022) · Medicine · doi:10.1097/md.0000000000030197 · Cited by 2 · see citing works
Treatment for subclinical hyperthyroidism in adults
Mugunthan, K., Mugunthan, N., & van Driel, M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010371 · Cited by 1 · see citing works
RetractedSubclinical Thyroid Dysfunction in the Elderly
Ko, K. D. (2014) · Journal of the Korean Geriatrics Society · doi:10.4235/jkgs.2014.18.3.111 · Cited by 1 · see citing works
Screening, Diagnostic, and Monitoring Challenges in Hypothyroidism: 2010
Hennessey, J. V. (2010) · Endocrine Practice · doi:10.1016/s1530-891x(20)42868-x · Cited by 1 · see citing works
Cardiac Activity Assessed in vivo and in Vitro in Rats Treated with Propiltiouracil (PTU)
de Almeida, M. A., Marcelino, K. B., Costa, W. T. M., de Brito, A. K. L., de Bessa, N. G. F., de Araújo, G. C., & Ogawa, W. N. (2019) · International Journal of Advanced Engineering Research and Science · doi:10.22161/ijaers.6.5.67
Prado-Uribe, M. D. C., Ventura, M.-D.-J., Ávila–Díaz, M., Mora, C. J., Méndez-Durán, A., Villanueva-Noches, D., Cisneros, A., Ilabaca, B., Cueto-Manzano, A. M., García-Contreras, F., et al. (2017) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2017.11.013 · Cited by 1 · see citing works
Treatment options of subclinical hyperthyroidism and cardiovascular risk
Kyrilli, A., Lytrivi, M., Lassen, P. B., & Corvilain, B. (2018) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2018.01.008 · Cited by 2 · see citing works
Echocardiographic Evaluation of Cardiac Function in Hypothyroidism
Rathor, D. P. K. (2018) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v6i3.175 · Cited by 1 · see citing works
Bloomgarden, Z. T. (2010) · Endocrine Practice · doi:10.4158/ep.16.s2.1
Clinical and therapeutic controversies on subclinical hyperthyroidism
Salles, F., & de Salles, D. M. (2014) · Medical Express · doi:10.5935/medicalexpress.2014.05.07
Pagsisihan, D., Andag‐Silva, A., Piores-Roderos, O., Gurango, J. A. L., & Escobin, M. A. (2014)
Potempa, M., & Jończyk, P. (2015) · Biology and Medicine · doi:10.4172/0974-8369.1000255
Anusha, K., & Kumar, R. (2016)
Influence of subclinical hyperthyroidism on the cardiovascular system
Russian Federation (2015)
Guías de práctica clínica para el tratamiento del hipotiroidismo
Brenta, G., Vaisman, M., Sgarbi, J. A., de Andrada, N. C., Bravo, P. P., Orlandi, A. M., & Graf, H. (2013)
Gabriel, E. A., Locali, R. F., Matsuoka, P. K., & Cherbo, T. (2011)
A Study of Evaluation of Cardiac Functions in Patients of Hypothyroidism
Talwar, T. (2017) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v5i10.156
Management of Prehypertension and Hypertension in Women of Childbearing Age
Olszanecka, A., & Czarnecka, D. (2018) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-75310-2_38
Özen, K., Akkaya, S., Polat, C., Ede, H., Görgel, A. F., & Öztürk, Ö. (2020) · e-Journal of Cardiovascular Medicine · doi:10.32596/ejcm.galenos.2020.07.037
Gurzau, D., Caloian, B., Comşa, H., Sitar-Tăut, A., Zdrenghea, D. T., & Pop, D. (2021) · Balneo and PRM Research Journal · doi:10.12680/balneo.2021.444
Maghami, Z. G., Alizadehasl, A., Khalili, N., Khalili, Y., Sadeghpour, A., Maharlou, M., & Rahbar, Z. (2022) · Multidisciplinary Cardiovascular Annals · doi:10.5812/mca-128541
Impact of Disease Duration on Left Atrial Function in Patients with Graves’ Disease
Murat, S., Durmaz, F. E., Gökçe, B. Ö., Korkmaz, E. S., Demirtas, E., Murat, B., Yorulmaz, G., Akalın, A., & Çavuşoğlu, Y. (2025) · Cardiology · doi:10.1159/000548952
Hassan, A. A., Shehawy, E. S. E., Esmail, M. S., Hossam-Eldin, G. E., Allah, R. M. F., Abozeid, H. E., Mohammed, D. S., Yassien, M., Ahmed, S. A., Salama, D. M., et al. (2025) · The Egyptian Journal of Radiology and Nuclear Medicine · doi:10.1186/s43055-025-01619-6
Li, M.-F., KE, J., Li, S., Wang, J.-W., Zhu, Z.-H., & Li, J.-B. (2021) · Figshare · doi:10.6084/m9.figshare.17126144
Cardiovascular manifestation in hypothyroid patient: a cross-sectional study
Alam, S., Siam, M. M., Khan, M. M. A., Ananya, S. N., Hossain, D. M. S., Alam, M. S., & Begum, F. (2025) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20254379
Association of Thyroid Dysfunction and TNF-α with Coronary Artery Disease: a Case-Control Study
Reshma Gopan, M., Chandrasekaran, D., Roy, D., Muninathan, N., Mahila, S., & Radhika., P. R. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02430-8
- Authors
- Pearce, E. N., Yang, Q., Benjamin, E. J., Aragam, J., & Vasan, R. S.
- Affiliations
- Boston University (US)
- National Heart, Lung, and Blood Institute (US)
- Corresponding author
- Pearce, Elizabeth N.
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2010-04
- Volume
- 20
- Issue
- 4
- Pages
- 369-373
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- PMC
- PMC2867586
- OpenAlex
- W2036273865
- Cited by
- 92
- References
- 43
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 13 · 2012: 9
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Thyroid (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1, N01-HC 25195)
- National Heart, Lung, and Blood Institute (2K24 HL 04334, N01‐HC25195, K24HL004334)
- National Institute of Diabetes and Digestive and Kidney Diseases (5K23DK4611)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- thyroid-stimulating hormone, thyroid function, left ventricular structure, left ventricular function, subclinical hypothyroidism, subclinical hyperthyroidism, left ventricular mass, left ventricular wall thickness, left atrial diameter, fractional shortening, systolic function, sex differences, Framingham Heart Study
- MeSH terms
- Aged, Echocardiography, Female, Heart Atria, Heart Ventricles, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Regression Analysis, Thyroid Function Tests, Thyroid Gland, Thyrotropin, Odds Ratio
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