The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Complications of Central Neck Dissection in Patients with Papillary Thyroid Carcinoma: Results of a Study on 1087 Patients and Review of the Literature
Abstract
BACKGROUND: Prophylactic central neck dissection (CND) has been proposed in the treatment of patients affected by papillary thyroid carcinoma (PTC) with clinically negative neck lymph nodes. The procedure allows pathologic staging of lymph nodes of the central compartment and treatment of the micrometastases. Nevertheless, the morbidity that its routine use adds to the total thyroidectomy must be taken into account. The aim of this study was to characterize the morbidity that CND adds to the total thyroidectomy. METHODS: This was a retrospective study of 1087 patients with PTC and clinically negative neck lymph nodes. Patients were divided into three study groups: Group A, total thyroidectomy; Group B, total thyroidectomy and ipsilateral CND; Group C, total thyroidectomy and bilateral CND. Primary endpoints of the study were evaluated by comparing the rates of transient and permanent recurrent laryngeal nerve (RLN) injury and hypoparathyroidism in the three study groups. RESULTS: Analysis of data showed no significant differences in the rate of transient (Group A: 3.6%, Group B: 3.9%, and Group C: 5.5%; p=0.404) and permanent (Group A: 1%, Group B: 0.5%, and Group C: 2.3%; p=0.099) RLN injury between the three study groups. Both ipsilateral CND and bilateral CND were associated with a higher rate of transient hypoparathyroidism (Group: A 27.7%, Group B: 36.1%, and Group C: 51.9%; p=0.014; odds ratio [OR]: 1.477; 95% confidence interval [CI]: 1.091-2.001; p<0.001; OR: 2.827; 95% CI: 2.065-3.870, respectively). Bilateral CND had a higher rate of permanent hypoparathyroidism (Group A: 6.3%, Group B: 7%, and Group C: 16.2%; p<0.001; OR: 2.860; 95% CI: 1.725-4.743). CONCLUSIONS: The increased rates of transient and permanent hypoparathyroidism in our series suggest a critical review of indications for the routine use of prophylactic CND for PTC. Prophylactic CND ipsilateral to the tumor associated with total thyroidectomy may represent an effective strategy for reducing the rate of permanent hypoparathyroidism. Concomitant completion contralateral paratracheal lymph node neck dissection should be performed in presence of lymph node metastasis on intraoperative frozen-section pathology. This approach limits the use of bilateral CND to patients with intraoperative pathological findings of lymph node metastases.
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Cites
Cooper, D. S., Doherty, G. M., Haugen, B. R., Kloos, R. T., Lee, S. L., Mandel, S. J., Mazzaferri, E. L., McIver, B., Pacini, F., Schlumberger, M., et al. (2009) · Thyroid · doi:10.1089/thy.2009.0110 · Cited by 6,707
Pacini, F., Schlumberger, M., Dralle, H., Elisei, R., Smit, J. W. A., Wiersinga, W., & _, _. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02158 · Cited by 1,976
Gharib, H., Papini, E., Valcavi, R., Baskin, H. J., Crescenzi, A., Dottorini, M. E., Duick, D. S., Guglielmi, R., Hamilton, C. R., Zeiger, M. A., et al. (2006) · Endocrine Practice · doi:10.4158/ep.12.1.63 · Cited by 681
Self-citationLundgren, C. I., Hall, P., Dickman, P. W., & Zedenius, J. (2006) · Cancer · doi:10.1002/cncr.21653 · Cited by 652
Hay, I. D. (1990) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30310-4 · Cited by 634
Carty, S. E., Cooper, D. S., Doherty, G. M., Duh, Q.-Y., Kloos, R. T., Mandel, S. J., Randolph, G. W., Stack, B. C., Steward, D. L., Terris, D. J., et al. (2009) · Thyroid · doi:10.1089/thy.2009.0159 · Cited by 609
Self-citationRole of preoperative ultrasonography in the surgical management of patients with thyroid cancer
Kouvaraki, M. A., Shapiro, S. E., Fornage, B. D., Edeiken-Monro, B. S., Sherman, S. I., Vassilopoulou-Sellin, R., Lee, J. E., & Evans, D. B. (2003) · Surgery · doi:10.1016/s0039-6060(03)00424-0 · Cited by 531
Pattern of Nodal Metastasis for Primary and Reoperative Thyroid Cancer
Machens, A., Hinze, R., Thomusch, O., & Dralle, H. (2002) · World Journal of Surgery · doi:10.1007/s00268-001-0176-3 · Cited by 508
Scheumann, G. F. W., Gimm, O., Wegener, G., Hundeshagen, H., & Dralle, H. (1994) · World Journal of Surgery · doi:10.1007/bf00353765 · Cited by 493
Stulak, J. M. (2006) · Archives of Surgery · doi:10.1001/archsurg.141.5.489 · Cited by 401
Cited by
Francis, G. L., Waguespack, S. G., Bauer, A. J., Angelos, P., Benvenga, S., Cerutti, J. M., Dinauer, C. A., Hamilton, J., Hay, I. D., Luster, M., et al. (2015) · Thyroid · doi:10.1089/thy.2014.0460 · Cited by 1,238
Self-citationLin, J. S., Bowles, E. J. A., Williams, S. B., & Morrison, C. C. (2017) · JAMA · doi:10.1001/jama.2017.0562 · Cited by 1,082
The changing incidence of thyroid cancer
Kitahara, C. M., & Sosa, J. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.110 · Cited by 1,051
Presentation of Hypoparathyroidism: Etiologies and Clinical Features
Shoback, D. M., Bilezikian, J. P., Costa, A. G., Dempster, D., Dralle, H., Khan, A. A., Peacock, M., Raffaelli, M., Silva, B. C., Thakker, R. V., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3909 · Cited by 371
Thyroid cancer: zealous imaging has increased detection and treatment of low risk tumours
Brito, J. P., Morris, J. C., & Montori, V. M. (2013) · BMJ · doi:10.1136/bmj.f4706 · Cited by 323
for the German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hematology; and the German Thyroid Cancer Patient Support Organization Ohne Schilddrüse leben e.V., Dralle, H., Musholt, T. J., Schabram, J., Steinmüller, T., Frilling, A., Simon, D., Goretzki, P. E., Niederle, B., Scheuba, C., et al. (2013) · Langenbeck's Archives of Surgery · doi:10.1007/s00423-013-1057-6 · Cited by 279
Metadata
- Authors
- Giordano, D., Valcavi, R., Thompson, G. B., Pedroni, C., Renna, L., Gradoni, P., & Barbieri, V.
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2012-09
- Volume
- 22
- Issue
- 9
- Pages
- 911-917
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W1965975087
- Cited by
- 400
- References
- 33
- FWCI
- 27.36
- Type
- journal article
- Language
- en
- Open access
- closed
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