The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Neutrophils and Wound Repair: Positive Actions and Negative Reactions
Open accessAbstract
SIGNIFICANCE: Neutrophils are one of the most abundant cells of the immune system and they are extremely active during the repair of cutaneous wounds. In general, the antimicrobial activity of neutrophils is effective and allows these cells to carry out their primary function of preventing wounds from becoming infected. RECENT ADVANCES: It is now known that in addition to sterilizing the wound, the weapons used by neutrophils to kill potential pathogens can also cause significant tissue damage to the host. This additional damage can lead to delayed healing and excessive scar formation. CRITICAL ISSUES: Much of the host damage caused by neutrophils results from the activity of proteases secreted by these cells. The clinical significance of this problem is highlighted by numerous studies showing that high levels of neutrophil-derived proteases are associated with chronic, non-healing wounds. FUTURE DIRECTIONS: Studies are currently being performed to evaluate new ways of counteracting protease activity in chronic wounds. Additional studies will have to be carried out to determine whether neutralizing neutrophil proteases can improve the healing of chronic wounds without sacrificing the ability of neutrophils to eliminate pathogens and risking infection.
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In the citing paper
“neutrophils defend against wound infection by phagocytosing pathogens then killing them through release of reactive oxygen species, proteases, or antimicrobial proteins [28].”
From Immunology of Wound Healing (2018) · cites this paper as [28]
In the citing paper
“In impaired models of wound healing, such as diabetes, where infection risk is higher, neutrophils are clearly required [28].”
From Immunology of Wound Healing (2018) · cites this paper as [28]
Citations
Cites
Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
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Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Matrix metalloproteinases as modulators of inflammation and innate immunity
Parks, W. C., Wilson, C. L., & López-Boado, Y. S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1418 · Cited by 1,929
Neutrophils: Molecules, Functions and Pathophysiological Aspects
Witko‐Sarsat, V., Rieu, P., Descamps‐Latscha, B., Lesavre, P., & Halbwachs‐Mecarelli, L. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780067 · Cited by 1,165
Neutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Neutrophil granules: a library of innate immunity proteins
Borregaard, N., Sørensen, O. E., & Theilgaard‐Mönch, K. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.06.002 · Cited by 735
Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9
Wysocki, A. B., Staiano-Coico, L., & Grinnell, F. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12359590 · Cited by 732
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694
Self-citationAccelerated wound closure in neutrophil-depleted mice
Dovi, J. V., He, L.-K., & DiPietro, L. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802406 · Cited by 525
Research works printed but not linked: 1
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Cited by
Sorted by citations
Wound Healing: A Cellular Perspective
Rodrigues, M., Kosaric, N., Bonham, C. A., & Gurtner, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00067.2017 · Cited by 3,211
Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980
“After being engulfed into the phagosome of the neutrophil, the microbe is killed and digested by toxic cationic enzymes and oxygen metabolites [16].”
BackgroundInfluentialFalanga, V., Isseroff, R. R., Soulika, A. M., Romanelli, M., Margolis, D. J., Kapp, S., Granick, M. S., & Harding, K. G. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00377-3 · Cited by 1,160
Promoting tissue regeneration by modulating the immune system
Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766
Metadata
- Authors
- Wilgus, T. A., Roy, S., & McDaniel, J. C.
- Affiliations
- The Ohio State University (US)
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2013-09
- Volume
- 2
- Issue
- 7
- Pages
- 379-388
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- PMC
- PMC3763227
- OpenAlex
- W2045982747
- Cited by
- 616
- References
- 47
- Citations by year
- 2026: 58 · 2025: 66 · 2024: 84 · 2023: 64 · 2022: 63 · 2021: 66 · 2020: 66 · 2019: 38 · 2018: 34 · 2017: 35 · 2016: 23 · 2015: 13 · 2014: 4
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in Wound Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio State University (UL1RR025755)
- National Institutes of Health (DK076566)
- National Cancer Institute (R01CA127109)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076566)
- National Center for Research Resources (UL1RR025755)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- neutrophils, wound healing, skin wounds, chronic wounds, neutrophil proteases, tissue damage, delayed healing, scar formation, antimicrobial activity, wound infection
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