The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing
Open accessAbstract
SIGNIFICANCE: This review highlights the critical role of transforming growth factor beta (TGF-β)1-3 within different phases of wound healing, in particular, late-stage wound healing. It is also very important to identify the TGF-β1-controlling factors involved in slowing down the healing process upon wound epithelialization. RECENT ADVANCES: TGF-β1, as a growth factor, is a known proponent of dermal fibrosis. Several strategies to modulate or regulate TGF's actions have been thoroughly investigated in an effort to create successful therapies. This study reviews current discourse regarding the many roles of TGF-β1 in wound healing by modulating infiltrated immune cells and the extracellular matrix. CRITICAL ISSUES: It is well established that TGF-β1 functions as a wound-healing promoting factor, and thereby if in excess it may lead to overhealing outcomes, such as hypertrophic scarring and keloid. Thus, the regulation of TGF-β1 in the later stages of the healing process remains as critical issue of which to better understand. FUTURE DIRECTIONS: One hypothesis is that cell communication is the key to regulate later stages of wound healing. To elucidate the role of keratinocyte/fibroblast cross talk in controlling the later stages of wound healing we need to: (1) identify those keratinocyte-released factors which would function as wound-healing stop signals, (2) evaluate the functionality of these factors in controlling the outcome of the healing process, and (3) formulate topical vehicles for these antifibrogenic factors to improve or even prevent the development of hypertrophic scarring and keloids as a result of deep trauma, burn injuries, and any type of surgical incision.
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Citations
Cites
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Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,857
Factors affecting wound healing
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PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Transforming Growth Factor β in Tissue Fibrosis
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TGFβ signals through a heteromeric protein kinase receptor complex
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Cited by
Zinc in Wound Healing Modulation
Lin, P.-H., Sermersheim, M., Li, H., Lee, P. H. U., Steinberg, S. M., & Ma, J. (2017) · Nutrients · doi:10.3390/nu10010016 · Cited by 643
The Role of MSC in Wound Healing, Scarring and Regeneration
Guillamat-Prats, R. (2021) · Cells · doi:10.3390/cells10071729 · Cited by 393
A review on nanoparticle based treatment for wound healing
Rajendran, N. K., Kumar, S. S. D., Houreld, N. N., & Abrahamse, H. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.01.009 · Cited by 389
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes
Maschalidi, S., Mehrotra, P., Keçeli, B. N., De Cleene, H. K. L., Lecomte, K., Van der Cruyssen, R., Janssen, P., Pinney, J., van Loo, G., Elewaut, D., et al. (2022) · Nature · doi:10.1038/s41586-022-04754-6 · Cited by 322
An Essential Role of NRF2 in Diabetic Wound Healing
Long, M., Rojo de la Vega, M., Wen, Q., Bharara, M., Jiang, T., Zhang, R., Zhou, S., Wong, P. K., Wondrak, G. T., Zheng, H., et al. (2016) · Diabetes · doi:10.2337/db15-0564 · Cited by 265
Metadata
- Authors
- Pakyari, M., Farrokhi, A., Maharlooei, M. K., & Ghahary, A.
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2013-06
- Volume
- 2
- Issue
- 5
- Pages
- 215-224
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- OpenAlex
- W2061251554
- Cited by
- 614
- References
- 55
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Pakyari, M., Farrokhi, A., Maharlooei, M. K., & Ghahary, A. (2013). Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing. Advances in Wound Care. https://doi.org/10.1089/wound.2012.0406
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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