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The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.

Computational anatomy: an emerging discipline

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Grenander, Ulf, Miller, Michael I.·1998·Quarterly of Applied Mathematics

Abstract

This paper studies mathematical methods in the emerging new discipline of Computational Anatomy. Herein we formalize the Brown/Washington University model of anatomy following the global pattern theory introduced in [1, 2], in which anatomies are represented as deformable templates, collections of 0, 1, 2, 3-dimensional manifolds. Typical structure is carried by the template with the variabilities accommodated via the application of random transformations to the background manifolds. The anatomical model is a quadruple ( Ω , H , I , P ) , the background space Ω = ˙ U α M α of 0, 1, 2, 3-dimensional manifolds, the set of diffeomorphic transformations on the background space H : Ω ↔ Ω , the space of idealized medical imagery I , and P the family of probability measures on H . The group of diffeomorphic transformations H is chosen to be rich enough so that a large family of shapes may be generated with the topologies of the template maintained. For normal anatomy one deformable template is studied, with ( Ω , H , I ) corresponding to a homogeneous space [3], in that it can be completely generated from one of its elements, I = H I t e m p , I t e m p ∈ I . For disease, a family of templates U α I t e m p α are introduced of perhaps varying dimensional transformation classes. The complete anatomy is a collection of homogeneous spaces I t o t a l = U α ( I α , H α ) .

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Metadata

Authors
Grenander, U., & Miller, M. I.
Venue
Quarterly of Applied Mathematics
Published
1998-12
Volume
56
Issue
4
Pages
617-694
ISSN
  • 0033-569X (ISSN-L)
  • 1552-4485
OpenAlex
W1503893179
Cited by
623
References
108
FWCI
16.00
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Computational anatomy: an emerging discipline. https://app.cochat.ai/papers/10.1090/qam/1668732
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Grenander, U., & Miller, M. I. (1998). Computational anatomy: an emerging discipline. Quarterly of Applied Mathematics. https://doi.org/10.1090/qam/1668732

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