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Cited by 850Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

Growth patterns in the developing brain detected by using continuum mechanical tensor maps

Thompson, Paul M., Giedd, Jay N., Woods, Roger P., MacDonald, David, Evans, Alan C., Toga, Arthur W.·2000·Nature
DOI 10.1038/35004593
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Abstract

The dynamic nature of growth and degenerative disease processes requires the design of sensitive strategies to detect, track and quantify structural change in the brain in its full spatial and temporal complexity. Although volumes of brain substructures are known to change during development, detailed maps of these dynamic growth processes have been unavailable. Here we report the creation of spatially complex, four-dimensional quantitative maps of growth patterns in the developing human brain, detected using a tensor mapping strategy with greater spatial detail and sensitivity than previously obtainable. By repeatedly scanning children (aged 3-15 years) across time spans of up to four years, a rostro-caudal wave of growth was detected at the corpus callosum, a fibre system that relays information between brain hemispheres. Peak growth rates, in fibres innervating association and language cortices, were attenuated after puberty, and contrasted sharply with a severe, spatially localized loss of subcortical grey matter. Conversely, at ages 3-6 years, the fastest growth rates occurred in frontal networks that regulate the planning of new actions. Local rates, profiles, and principal directions of growth were visualized in each individual child.

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Crossref · 10.1038/35004593

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  • In an earlier report, the authors developed an approach using tensor mapping to measure local growth rates and tissue-loss rates at a local level in the anatomy of the caudate and corpus callosum.

    “In an earlier report (28), we developed an approach using tensor mapping to measure the local growth rates and tissue-loss rates at a local level in the anatomy of the caudate and corpus callosum.”

    From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [28]

  • In very small regions of these structures, local growth rates exceeded 40% per year, and local tissue-loss rates reached 40% per year in small regions of the basal ganglia.

    “In very small regions of these structures, local growth rates exceeded 40% per year, and local tissue-loss rates reached 40% per year in small regions of the basal ganglia.”

    From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [28]

  • Thompson et al. (2000) found a localised grey matter decrease in the frontal cortex in the older group (11 to 15 years), providing further evidence of a sharp acceleration of grey matter density loss between childhood and adolescence in dorsal frontal cortex.

    “In the older group (11 to 15 years) a localised grey matter decrease in the frontal cortex was observed.This study provided further evidence of a sharp acceleration of grey matter density loss between childhood and adolescence in dorsal frontal cortex.”

    From Development of the adolescent brain: implications for executive function and social cognition (2006) · cites this paper as Thompson et al. (2000)

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Authors
Thompson, P. M., Giedd, J. N., Woods, R. P., MacDonald, D., Evans, A. C., & Toga, A. W.
Affiliations
  • University of California, Los Angeles (US)
  • National Institutes of Health (US)
  • Montreal Neurological Institute and Hospital (CA)
Corresponding author
Toga, Arthur W.
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2000-03
Volume
404
Issue
6774
Pages
190-193
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/35004593
OpenAlex
W2006557707
Cited by
850
References
18
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 15 · 2022: 9 · 2021: 11 · 2020: 23 · 2019: 15 · 2018: 20 · 2017: 23 · 2016: 28 · 2015: 33 · 2014: 31 · 2013: 59 · 2012: 37
FWCI
42.31
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
brain growth, human brain development, corpus callosum, gray matter loss, puberty, frontal cortex, association cortex, language cortex, continuum mechanics, longitudinal neuroimaging, children
MeSH terms
Adolescent, Brain, Brain Mapping, Child, Child, Preschool, Corpus Callosum, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male

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