Cited by 152Cellular transport and secretionCalcium signaling and nucleotide metabolismAutophagy in Disease and Therapy

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Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein

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Wang, Tuanlao, Hong, Wanjin·2002·Molecular Biology of the Cell

DOI 10.1091/mbc.e02-05-0280PMC PMC138636

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Abstract

We present evidence to suggest the existence of a regulatory pathway for the Golgi apparatus to modulate the spatial positioning of otherwise distantly located lysosomes. Rab34, a new member of the Rab GTPase family, is associated primarily with the Golgi apparatus. Expression of wild-type or GTP-restricted but not GDP-restricted versions of Rab34 causes spatial redistribution of lysosomes from the periphery to the peri-Golgi region. The regulation of lysosomal positioning by Rab34 depends on its association with the membrane mediated by prenylation and its direct interaction with Rab-interacting lysosomal protein (RILP). This biological activity, mediated by Rab34-RILP interaction, is dependent on Lys82 in the switch I region. Our results have uncovered a novel mechanism for the Golgi apparatus to regulate the spatial distribution of another organelle.

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Authors: Wang, T., & Hong, W.
Affiliations: Institute of Molecular and Cell Biology (SG)
ORCID: Wang, Tuanlao
Hong, Wanjin
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2002-12
Volume: 13
Issue: 12
Pages: 4317-4332
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.e02-05-0280
PMC: PMC138636
OpenAlex: W2137315893
Cited by: 147
References: 48
Citations by year: 2026: 4 · 2025: 6 · 2024: 11 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 3 · 2012: 6
FWCI: 2.19
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Molecular Biology of the Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National University of Singapore
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: lysosome positioning, Golgi apparatus, Rab34, Rab GTPases, RILP, prenylation, switch I region
MeSH terms: Amino Acid Sequence, Animals, Axons, Base Sequence, Carrier Proteins, Cells, Cultured, Cloning, Molecular, Cytoskeleton, Glutathione Transferase, Golgi Apparatus, HeLa Cells, Humans, Lysine, Lysosomes, Microscopy, Fluorescence, Models, Genetic, Molecular Sequence Data, Plant Proteins, Protein Binding, Transfection, Mutagenesis, Site-Directed, Sequence Homology, Amino Acid, DNA, Complementary, Fluorescent Antibody Technique, Indirect, rab GTP-Binding Proteins, Two-Hybrid System Techniques, Adaptor Proteins, Signal Transducing, Mice, Rats

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Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein

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