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Mechanisms and functions of lysosome positioning

Pu, Jing, Guardia, Carlos M., Keren-Kaplan, Tal, Bonifacino, Juan S.·2016·Journal of Cell Science
DOI 10.1242/jcs.196287
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Abstract

Lysosomes have been classically considered terminal degradative organelles, but in recent years they have been found to participate in many other cellular processes, including killing of intracellular pathogens, antigen presentation, plasma membrane repair, cell adhesion and migration, tumor invasion and metastasis, apoptotic cell death, metabolic signaling and gene regulation. In addition, lysosome dysfunction has been shown to underlie not only rare lysosome storage disorders but also more common diseases, such as cancer and neurodegeneration. The involvement of lysosomes in most of these processes is now known to depend on the ability of lysosomes to move throughout the cytoplasm. Here, we review recent findings on the mechanisms that mediate the motility and positioning of lysosomes, and the importance of lysosome dynamics for cell physiology and pathology.

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Research works printed but not linked: 134

  1. Aittaleb, 2015, Failure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn, J. Cell Sci., 128, 3744, 10.1242/jcs.172536 · DOI · Paper page
  2. Al-Bassam, 2007, Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c, Cell Motil. Cytoskeleton, 64, 377, 10.1002/cm.20190 · DOI
  3. Andzelm, 2007, Myosin IIA is required for cytolytic granule exocytosis in human NK cells, J. Exp. Med., 204, 2285, 10.1084/jem.20071143 · DOI
  4. Baas, 1988, Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite, Proc. Natl. Acad. Sci. USA, 85, 8335, 10.1073/pnas.85.21.8335 · DOI · Paper page
  5. Bagshaw, 2006, The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes, Biochem. Biophys. Res. Commun., 344, 1186, 10.1016/j.bbrc.2006.03.221 · DOI
  6. Ballabio, 2016, The awesome lysosome, EMBO Mol. Med., 8, 73, 10.15252/emmm.201505966 · DOI
  7. Bentley, 2015, A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations, J. Cell Biol., 208, 273, 10.1083/jcb.201408056 · DOI
  8. Blott, 2002, Secretory lysosomes, Nat. Rev. Mol. Cell Biol., 3, 122, 10.1038/nrm732 · DOI
  9. Boucrot, 2005, The intracellular fate of Salmonella depends on the recruitment of kinesin, Science, 308, 1174, 10.1126/science.1110225 · DOI
  10. Braulke, 2009, Sorting of lysosomal proteins, Biochim. Biophys. Acta, 1793, 605, 10.1016/j.bbamcr.2008.10.016 · DOI
  11. Brown, 2005, Kinesin-2 is a motor for late endosomes and lysosomes, Traffic, 6, 1114, 10.1111/j.1600-0854.2005.00347.x · DOI · Paper page
  12. Burkhardt, 1997, Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution, J. Cell Biol., 139, 469, 10.1083/jcb.139.2.469 · DOI
  13. Cai, 2009, Single molecule imaging reveals differences in microtubule track selection between kinesin motors, PLoS Biol., 7, e1000216, 10.1371/journal.pbio.1000216 · DOI · Paper page
  14. Cai, 2010, Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons, Neuron, 68, 73, 10.1016/j.neuron.2010.09.022 · DOI · Paper page
  15. Cantalupo, 2001, Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes, EMBO J., 20, 683, 10.1093/emboj/20.4.683 · DOI · Paper page
  16. Cardoso, 2009, Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells, PLoS ONE, 4, e4424, 10.1371/journal.pone.0004424 · DOI
  17. Caviston, 2011, Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes, Mol. Biol. Cell, 22, 478, 10.1091/mbc.E10-03-0233 · DOI
  18. Chen, 2013, Autophagic lysosome reformation, Exp. Cell Res., 319, 142, 10.1016/j.yexcr.2012.09.004 · DOI
  19. Chow, 2002, Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane, Nature, 418, 988, 10.1038/nature01006 · DOI · Paper page
  20. Chu, 2015, Cholesterol transport through lysosome-peroxisome membrane contacts, Cell, 161, 291, 10.1016/j.cell.2015.02.019 · DOI · Paper page
  21. Circu, 2016, A novel high content imaging-based screen identifies the anti-helminthic niclosamide as an inhibitor of lysosome anterograde trafficking and prostate cancer cell invasion, PLoS ONE, 11, e0146931, 10.1371/journal.pone.0146931 · DOI
  22. Colin, 2008, Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons, EMBO J., 27, 2124, 10.1038/emboj.2008.133 · DOI
  23. Cordonnier, 2001, Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes, Mol. Biol. Cell, 12, 4013, 10.1091/mbc.12.12.4013 · DOI
  24. Daniele, 2011, A role for Rab7 in the movement of secretory granules in cytotoxic T lymphocytes, Traffic, 12, 902, 10.1111/j.1600-0854.2011.01194.x · DOI
  25. D'costa, 2015, Salmonella disrupts host endocytic trafficking by SopD2-mediated inhibition of Rab7, Cell Rep., 12, 1508, 10.1016/j.celrep.2015.07.063 · DOI
  26. DeBoer, 2008, Conventional kinesin holoenzymes are composed of heavy and light chain homodimers, Biochemistry, 47, 4535, 10.1021/bi702445j · DOI
  27. Dehmelt, 2005, The MAP2/Tau family of microtubule-associated proteins, Genome Biol., 6, 204, 10.1186/gb-2004-6-1-204 · DOI · Paper page
  28. Dell'angelica, 2000, Lysosome-related organelles, FASEB J., 14, 1265, 10.1096/fj.14.10.1265 · DOI · Paper page
  29. Dodson, 2012, Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning, Hum. Mol. Genet., 21, 1350, 10.1093/hmg/ddr573 · DOI
  30. Dozynkiewicz, 2012, Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression, Dev. Cell, 22, 131, 10.1016/j.devcel.2011.11.008 · DOI
  31. Du, 2016, Kinesin 1 drives autolysosome tubulation, Dev. Cell, 37, 326, 10.1016/j.devcel.2016.04.014 · DOI
  32. Duarte, 2016, Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis-regulation of BORCS7, AS3MT, and NT5C2 in the human brain, Am. J. Med. Genet. B Neuropsychiatr. Genet., 171, 806, 10.1002/ajmg.b.32445 · DOI
  33. Dumont, 2010, SKIP, the host target of the Salmonella virulence factor SifA, promotes kinesin-1-dependent vacuolar membrane exchanges, Traffic, 11, 899, 10.1111/j.1600-0854.2010.01069.x · DOI
  34. Dunn, 2008, Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells, J. Cell Sci., 121, 1085, 10.1242/jcs.026492 · DOI · Paper page
  35. Encarnação, 2016, A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair, J. Cell Biol., 213, 631, 10.1083/jcb.201511093 · DOI
  36. Erie, 2015, Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease, Eur. J. Neurosci., 42, 1941, 10.1111/ejn.12957 · DOI
  37. Falcon-Perez, 2002, BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules, J. Biol. Chem., 277, 28191, 10.1074/jbc.M204011200 · DOI
  38. Fraldi, 2016, Brain disorders due to lysosomal dysfunction, Annu. Rev. Neurosci., 39, 277, 10.1146/annurev-neuro-070815-014031 · DOI
  39. Frasa, 2010, Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation, Curr. Biol., 20, 198, 10.1016/j.cub.2009.12.053 · DOI
  40. Fu, 2013, JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors, J. Cell Biol., 202, 495, 10.1083/jcb.201302078 · DOI
  41. Ganley, 2006, Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells, J. Biol. Chem., 281, 17890, 10.1074/jbc.M601679200 · DOI
  42. Ganley, 2004, Rab9 GTPase regulates late endosome size and requires effector interaction for its stability, Mol. Biol. Cell, 15, 5420, 10.1091/mbc.E04-08-0747 · DOI
  43. Glunde, 2003, Extracellular acidification alters lysosomal trafficking in human breast cancer cells, Neoplasia, 5, 533, 10.1016/S1476-5586(03)80037-4 · DOI
  44. Guardia, 2016, BORC functions upstream of kinesins 1 and 3 to coordinate regional movement of lysosomes along different microtubule tracks, Cell Reports, 10.1016/j.celrep.2016.10.062 · DOI · Paper page
  45. Hammond, 2008, Tubulin modifications and their cellular functions, Curr. Opin. Cell Biol., 20, 71, 10.1016/j.ceb.2007.11.010 · DOI · Paper page
  46. Harada, 1998, Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein, J. Cell Biol., 141, 51, 10.1083/jcb.141.1.51 · DOI
  47. Hirokawa, 2008, Intracellular transport and kinesin superfamily proteins, kifs: structure, function, and dynamics, Physiol. Rev., 88, 1089, 10.1152/physrev.00023.2007 · DOI
  48. Hofmann, 2006, An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility, J. Cell Sci., 119, 1494, 10.1242/jcs.02958 · DOI
  49. Hollenbeck, 1990, Radial extension of macrophage tubular lysosomes supported by kinesin, Nature, 346, 864, 10.1038/346864a0 · DOI
  50. Huynh, 2007, LAMP proteins are required for fusion of lysosomes with phagosomes, EMBO J., 26, 313, 10.1038/sj.emboj.7601511 · DOI · Paper page
  51. Ikegami, 2007, Loss of α-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function, Proc. Natl Acad. Sci. USA, 104, 3213, 10.1073/pnas.0611547104 · DOI
  52. Ishikawa, 2012, Structural biology of cytoplasmic and axonemal dyneins, J. Struct. Biol., 179, 229, 10.1016/j.jsb.2012.05.016 · DOI
  53. Itakura, 2010, Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins, Autophagy, 6, 764, 10.4161/auto.6.6.12709 · DOI · Paper page
  54. Jackson, 2008, The Salmonella virulence protein SifA is a G protein antagonist, Proc. Natl. Acad. Sci. USA, 105, 14141, 10.1073/pnas.0801872105 · DOI
  55. Jongsma, 2016, An ER-associated pathway defines endosomal architecture for controlled cargo transport, Cell, 166, 152, 10.1016/j.cell.2016.05.078 · DOI
  56. Jordens, 2001, The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors, Curr. Biol., 11, 1680, 10.1016/S0960-9822(01)00531-0 · DOI · Paper page
  57. Kallunki, 2013, Cancer-associated lysosomal changes: friends or foes?, Oncogene, 32, 1995, 10.1038/onc.2012.292 · DOI
  58. Kimura, 2008, Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes, Cell Struct. Funct., 33, 109, 10.1247/csf.08005 · DOI · Paper page
  59. Knodler, 2005, The Salmonella effector PipB2 affects late endosome/lysosome distribution to mediate Sif extension, Mol. Biol. Cell, 16, 4108, 10.1091/mbc.E05-04-0367 · DOI
  60. Ko, 2001, Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events, Mol. Biol. Cell, 12, 601, 10.1091/mbc.12.3.601 · DOI
  61. Konishi, 2009, Tubulin tyrosination navigates the kinesin-1 motor domain to axons, Nat. Neurosci., 12, 559, 10.1038/nn.2314 · DOI
  62. Korolchuk, 2011, Lysosomal positioning coordinates cellular nutrient responses, Nat. Cell Biol., 13, 453, 10.1038/ncb2204 · DOI · Paper page
  63. Kroemer, 2005, Lysosomes and autophagy in cell death control, Nat. Rev. Cancer, 5, 886, 10.1038/nrc1738 · DOI
  64. Krzewski, 2013, LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity, Blood, 121, 4672, 10.1182/blood-2012-08-453738 · DOI · Paper page
  65. Kurowska, 2012, Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex, Blood, 119, 3879, 10.1182/blood-2011-09-382556 · DOI
  66. Lebrand, 2002, Late endosome motility depends on lipids via the small GTPase Rab7, EMBO J., 21, 1289, 10.1093/emboj/21.6.1289 · DOI
  67. Lee, 2011, Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy, J. Neurosci., 31, 7817, 10.1523/JNEUROSCI.6412-10.2011 · DOI
  68. Li, 2016, A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus, Nat. Med., 22, 649, 10.1038/nm.4096 · DOI
  69. Lin, 1992, Immunolocalization of cytoplasmic dynein to lysosomes in cultured cells, J. Cell Sci., 101, 125, 10.1242/jcs.101.1.125 · DOI
  70. Lipka, 2016, Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites, EMBO J., 35, 302, 10.15252/embj.201592929 · DOI
  71. Loubéry, 2008, Different microtubule motors move early and late endocytic compartments, Traffic, 9, 492, 10.1111/j.1600-0854.2008.00704.x · DOI · Paper page
  72. Macpherson, 2014, CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer, J. Cell Sci., 127, 3893, 10.1242/jcs.135947 · DOI · Paper page
  73. Martina, 2012, MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB, Autophagy, 8, 903, 10.4161/auto.19653 · DOI · Paper page
  74. Marx, 2005, Interaction of kinesin motors, microtubules, and MAPs, J. Muscle Res. Cell Motil., 27, 125, 10.1007/s10974-005-9051-4 · DOI
  75. Matsushita, 2004, A novel kinesin-like protein, KIF1Bβ3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells, Traffic, 5, 140, 10.1111/j.1600-0854.2003.00165.x · DOI
  76. Matsuzaki, 2011, Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation, Mol. Biol. Cell, 22, 4602, 10.1091/mbc.E11-01-0068 · DOI · Paper page
  77. Matteoni, 1987, Translocation and clustering of endosomes and lysosomes depends on microtubules, J. Cell Biol., 105, 1253, 10.1083/jcb.105.3.1253 · DOI
  78. McGourty, 2012, Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function, Science, 338, 963, 10.1126/science.1227037 · DOI
  79. Melo, 2015, Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome, Hum. Mol. Genet., 24, 6877, 10.1093/hmg/ddv388 · DOI
  80. Mizuno, 2003, Rabring7, a novel Rab7 target protein with a RING finger motif, Mol. Biol. Cell, 14, 3741, 10.1091/mbc.E02-08-0495 · DOI · Paper page
  81. Mohamed, 2006, Cysteine cathepsins: multifunctional enzymes in cancer, Nat. Rev. Cancer, 6, 764, 10.1038/nrc1949 · DOI
  82. Monteiro, 2013, Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia, J. Cell Biol., 203, 1063, 10.1083/jcb.201306162 · DOI
  83. Moriyama, 2002, Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles, Traffic, 3, 666, 10.1034/j.1600-0854.2002.30908.x · DOI
  84. Mrakovic, 2012, Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages, Traffic, 13, 1667, 10.1111/tra.12003 · DOI · Paper page
  85. Mukhopadhyay, 2016, Lively lysosomes, ASBMB Today, 15, 7
  86. Munch, 2004, Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS, Neurology, 63, 724, 10.1212/01.WNL.0000134608.83927.B1 · DOI
  87. Nakata, 1995, Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport, J. Cell Biol., 131, 1039, 10.1083/jcb.131.4.1039 · DOI
  88. Nakata, 2011, Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport, J. Cell Biol., 194, 245, 10.1083/jcb.201104034 · DOI · Paper page
  89. Neeft, 2005, Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells, Mol. Biol. Cell, 16, 731, 10.1091/mbc.E04-10-0923 · DOI
  90. Nishimura, 2002, A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells, Histochem. J., 34, 189, 10.1023/A:1021702812146 · DOI · Paper page
  91. Nishimura, 2003, Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes, Pathol. Oncol. Res., 9, 83, 10.1007/BF03033750 · DOI · Paper page
  92. Noda, 1998, Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast, J. Biol. Chem., 273, 3963, 10.1074/jbc.273.7.3963 · DOI
  93. Nordmann, 2010, The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7, Curr. Biol., 20, 1654, 10.1016/j.cub.2010.08.002 · DOI
  94. Nottingham, 2012, RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36, J. Biol. Chem., 287, 22740, 10.1074/jbc.M112.362558 · DOI
  95. Palmieri, 2011, Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways, Hum. Mol. Genet., 20, 3852, 10.1093/hmg/ddr306 · DOI · Paper page
  96. Parenti, 2015, Lysosomal storage diseases: from pathophysiology to therapy, Annu. Rev. Med., 66, 471, 10.1146/annurev-med-122313-085916 · DOI · Paper page
  97. Paschal, 1987, Retrograde transport by the microtubule-associated protein MAP 1C, Nature, 330, 181, 10.1038/330181a0 · DOI
  98. Peralta, 2010, Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence, J. Biol. Chem., 285, 16814, 10.1074/jbc.M110.111633 · DOI
  99. Poirier, 2013, Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly, Nat. Genet., 45, 639, 10.1038/ng.2613 · DOI
  100. Poupon, 2003, The role of mVps18p in clustering, fusion, and intracellular localization of late endocytic organelles, Mol. Biol. Cell, 14, 4015, 10.1091/mbc.E03-01-0040 · DOI
  101. Progida, 2007, RILP is required for the proper morphology and function of late endosomes, J. Cell Sci., 120, 3729, 10.1242/jcs.017301 · DOI
  102. Pu, 2015, BORC, a multisubunit complex that regulates lysosome positioning, Dev. Cell, 33, 176, 10.1016/j.devcel.2015.02.011 · DOI · Paper page
  103. Raiborg, 2015, Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth, Nature, 520, 234, 10.1038/nature14359 · DOI
  104. Raiborg, 2016, ER–endosome contact sites in endosome positioning and protrusion outgrowth, Biochem. Soc. Trans., 44, 441, 10.1042/BST20150246 · DOI · Paper page
  105. Reddy, 2001, Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes, Cell, 106, 157, 10.1016/S0092-8674(01)00421-4 · DOI
  106. Reed, 2006, Microtubule acetylation promotes kinesin-1 binding and transport, Curr. Biol., 16, 2166, 10.1016/j.cub.2006.09.014 · DOI · Paper page
  107. Reid, 2002, A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10), Am. J. Hum. Genet., 71, 1189, 10.1086/344210 · DOI
  108. Rocha, 2009, Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning, J. Cell Biol., 185, 1209, 10.1083/jcb.200811005 · DOI
  109. Rodriguez, 1997, Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells, J. Cell Biol., 137, 93, 10.1083/jcb.137.1.93 · DOI
  110. Rosa-Ferreira, 2011, Arl8 and SKIP act together to link lysosomes to kinesin-1, Dev. Cell, 21, 1171, 10.1016/j.devcel.2011.10.007 · DOI · Paper page
  111. Saftig, 2009, Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function, Nat. Rev. Mol. Cell Biol., 10, 623, 10.1038/nrm2745 · DOI · Paper page
  112. Sancak, 2008, The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1, Science, 320, 1496, 10.1126/science.1157535 · DOI · Paper page
  113. Santama, 1998, KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation, EMBO J., 17, 5855, 10.1093/emboj/17.20.5855 · DOI
  114. Saric, 2016, mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells, Mol. Biol. Cell, 27, 321, 10.1091/mbc.E15-05-0272 · DOI
  115. Schiefermeier, 2014, The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration, J. Cell Biol., 205, 525, 10.1083/jcb.201310043 · DOI
  116. Schuster, 2011, Transient binding of dynein controls bidirectional long-range motility of early endosomes, Proc. Natl. Acad. Sci. USA, 108, 3618, 10.1073/pnas.1015839108 · DOI
  117. Schwenk, 2014, The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes, EMBO J., 33, 450, 10.1002/embj.201385857 · DOI
  118. Settembre, 2012, A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB, EMBO J., 31, 1095, 10.1038/emboj.2012.32 · DOI · Paper page
  119. Starcevic, 2004, Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1), J. Biol. Chem., 279, 28393, 10.1074/jbc.M402513200 · DOI
  120. Starling, 2016, Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes, EMBO Rep., 17, 823, 10.15252/embr.201541382 · DOI · Paper page
  121. Steffan, 2014, Supporting a role for the GTPase Rab7 in prostate cancer progression, PLoS One, 9, e87882, 10.1371/journal.pone.0087882 · DOI
  122. Stinchcombe, 2006, Centrosome polarization delivers secretory granules to the immunological synapse, Nature, 443, 462, 10.1038/nature05071 · DOI · Paper page
  123. Sung, 2008, Drosophila ensconsin promotes productive recruitment of kinesin-1 to microtubules, Dev. Cell, 15, 866, 10.1016/j.devcel.2008.10.006 · DOI
  124. Tuli, 2013, Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity, Mol. Biol. Cell, 24, 3721, 10.1091/mbc.E13-05-0259 · DOI
  125. Uusi-Rauva, 2012, Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments, Cell. Mol. Life Sci., 69, 2075, 10.1007/s00018-011-0913-1 · DOI
  126. Verhoeven, 2003, Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy, Am. J. Hum. Genet., 72, 722, 10.1086/367847 · DOI
  127. Vyas, 2007, Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells, J. Immunol., 178, 7199, 10.4049/jimmunol.178.11.7199 · DOI · Paper page
  128. Yang, 2010, Mammalian autophagy: core molecular machinery and signaling regulation, Curr. Opin. Cell Biol., 22, 124, 10.1016/j.ceb.2009.11.014 · DOI · Paper page
  129. Yau, 2016, Dendrites in vitro and in vivo contain microtubules of opposite polarity and axon formation correlates with uniform plus-end-out microtubule orientation, J. Neurosci., 36, 1071, 10.1523/JNEUROSCI.2430-15.2016 · DOI
  130. Yu, 2016, Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells, Oncotarget, 7, 14693, 10.18632/oncotarget.7492 · DOI
  131. Zaarur, 2014, Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport, Mol. Cell. Biol., 34, 1336, 10.1128/MCB.00103-14 · DOI
  132. Zhang, 2005, TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7, Biochem. Biophys. Res. Commun., 335, 154, 10.1016/j.bbrc.2005.07.070 · DOI
  133. Zhang, 2014, Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2, Structure, 22, 1408, 10.1016/j.str.2014.08.005 · DOI
  134. Zhao, 2001, Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta, Cell, 105, 587, 10.1016/S0092-8674(01)00363-4 · DOI

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Metadata

Authors
Pu, J., Guardia, C. M., Keren-Kaplan, T., & Bonifacino, J. S.
Affiliations
Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, MD 20892 , USA
ORCID
Bonifacino, Juan S.
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2016-12-01
Volume
129
Issue
23
Pages
4329-4339
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.196287
Cited by
570
References
13
Language
en
Licence
www.biologists.com/user-licence-1-1/ (vor, 182 d)
Funders
National Institute of Child Health and Human Development (ZIA HD001607)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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