The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth
Open accessAbstract
The chondroitin sulfate proteoglycan versican is one of the major extracellular components in the developing and adult brain. Here, we show that isoforms of versican play different roles in neuronal differentiation and neurite outgrowth. Expression of versican V1 isoform in PC12 cells induced complete differentiation, whereas expression of V2 induced an aborted differentiation accompanied by apoptosis. V1 promoted neurite outgrowth of hippocampal neurons, but V2 failed to do so. V1 transfection enhanced expression of epidermal growth factor receptor and integrins, and facilitated sustained extracellular signal-regulated kinase/MAPK phosphorylation. Blockade of the epidermal growth factor receptor, β1 integrin, or Src significantly inhibited neuronal differentiation. Finally, we demonstrated that versican V1 isoform also promoted differentiation of neural stem cells into neurons. Our results have implications for understanding how versican regulates neuronal development, function, and repair.
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“Versican (VCAN), which promotes neurite outgrowth98, carries three HHMCs”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [98]
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Cites
Integrins: A family of cell surface receptors
Hynes, R. O. (1987) · Cell · doi:10.1016/0092-8674(87)90233-9 · Cited by 4,258
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Signal transduction from the extracellular matrix.
Juliano, R. L., & Haskill, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.3.577 · Cited by 1,683
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679
Astroglia induce neurogenesis from adult neural stem cells
Song, H., Stevens, C. F., & Gage, F. H. (2002) · Nature · doi:10.1038/417039a · Cited by 1,452
Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections
Vaudry, D., Stork, P. A., Lazarovici, P., & Eiden, L. E. (2002) · Science · doi:10.1126/science.1071552 · Cited by 795
Multiple domains of the large fibroblast proteoglycan, versican.
Zimmermann, D., & Ruoslahti, E. I. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08447.x · Cited by 652
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Kukekov, V. G., Laywell, E. D., Suslov, O. N., Davies, K. G., Scheffler, B., Thomas, L. B., O'Brien, T. J., Kusakabe, M., & Steindler, D. A. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7028 · Cited by 525
Barres, B. A., Silverstein, B. E., Corey, D. P., & Chun, L. L. Y. (1988) · Neuron · doi:10.1016/0896-6273(88)90127-4 · Cited by 520
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The interaction of versican with its binding partners
Yao Jiong, W. U., Pierre, D. P. L., Wu, J. S. R., Yee, A., & Yang, B. B. (2005) · Cell Research · doi:10.1038/sj.cr.7290318 · Cited by 407
Self-citationComposition of Perineuronal Net Extracellular Matrix in Rat Brain
Deepa, S. S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., & Fawcett, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600544200 · Cited by 367
Joyce, K., Fabra, G. T., Bozkurt, Y., & Pandit, A. S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00512-8 · Cited by 342
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation
Kubo, N., Ishii, H., Xiong, X., Bianco, S., Meitinger, F., Hu, R., Hocker, J. D., Conte, M., Gorkin, D., Yu, M., et al. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-00539-5 · Cited by 289
The biological role and regulation of versican levels in cancer
Ricciardelli, C., Sakko, A. J., Ween, M. P., Russell, D. L., & Horsfall, D. J. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-009-9182-y · Cited by 225
Metadata
- Authors
- Wu, Y., Sheng, W., Chen, L., Dong, H., Lee, V., Lu, F., Wong, C. S., Lu, W.-Y., & Yang, B. B.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
- Venue
- Molecular Biology of the Cell
- Published
- 2004-05
- Volume
- 15
- Issue
- 5
- Pages
- 2093-2104
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC404007
- OpenAlex
- W2146306557
- Cited by
- 107
- References
- 50
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 2 · 2012: 6
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neuronal differentiation, neurite outgrowth, chondroitin sulfate proteoglycans, PC12 cells, hippocampal neurons, epidermal growth factor receptor, beta1 integrin, Src kinase, ERK signaling, neural stem cell differentiation, apoptosis, neuronal development, brain extracellular matrix
- MeSH terms
- Animals, Carrier Proteins, Cell Differentiation, Genetic Vectors, Glycoproteins, Hippocampus, Nerve Growth Factors, Nerve Tissue Proteins, Neurons, Phosphorylation, Quinones, Transfection, Gene Expression, Integrins, Cyclins, Benzoquinones, Neurites, PC12 Cells, Rifabutin, Integrin beta1, Protein Isoforms, Mitogen-Activated Protein Kinase Kinases, Lactams, Macrocyclic, Rats, Versicans, ErbB Receptors
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