Cited by 107Proteoglycans and glycosaminoglycans researchNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

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Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth

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Wu, Yaojiong, Sheng, Wang, Chen, Liwen, Dong, Haiheng, Lee, Vivian, Lu, Fred, Wong, C. Shun, Lu, Wei-Yang, Yang, Burton B.·2004·Molecular Biology of the Cell

DOI 10.1091/mbc.e03-09-0667PMC PMC404007

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Abstract

The chondroitin sulfate proteoglycan versican is one of the major extracellular components in the developing and adult brain. Here, we show that isoforms of versican play different roles in neuronal differentiation and neurite outgrowth. Expression of versican V1 isoform in PC12 cells induced complete differentiation, whereas expression of V2 induced an aborted differentiation accompanied by apoptosis. V1 promoted neurite outgrowth of hippocampal neurons, but V2 failed to do so. V1 transfection enhanced expression of epidermal growth factor receptor and integrins, and facilitated sustained extracellular signal-regulated kinase/MAPK phosphorylation. Blockade of the epidermal growth factor receptor, β1 integrin, or Src significantly inhibited neuronal differentiation. Finally, we demonstrated that versican V1 isoform also promoted differentiation of neural stem cells into neurons. Our results have implications for understanding how versican regulates neuronal development, function, and repair.

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Authors: Wu, Y., Sheng, W., Chen, L., Dong, H., Lee, V., Lu, F., Wong, C. S., Lu, W.-Y., & Yang, B. B.
Affiliations: Sunnybrook Health Science Centre (CA)
Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
ORCID: Wu, Yaojiong
Chen, Liwen
Yang, Burton B.
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2004-05
Volume: 15
Issue: 5
Pages: 2093-2104
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.e03-09-0667
PMC: PMC404007
OpenAlex: W2146306557
Cited by: 107
References: 50
Citations by year: 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 2 · 2012: 6
FWCI: 3.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Biology of the Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: neuronal differentiation, neurite outgrowth, chondroitin sulfate proteoglycans, PC12 cells, hippocampal neurons, epidermal growth factor receptor, beta1 integrin, Src kinase, ERK signaling, neural stem cell differentiation, apoptosis, neuronal development, brain extracellular matrix
MeSH terms: Animals, Carrier Proteins, Cell Differentiation, Genetic Vectors, Glycoproteins, Hippocampus, Nerve Growth Factors, Nerve Tissue Proteins, Neurons, Phosphorylation, Quinones, Transfection, Gene Expression, Integrins, Cyclins, Benzoquinones, Neurites, PC12 Cells, Rifabutin, Integrin beta1, Protein Isoforms, Mitogen-Activated Protein Kinase Kinases, Lactams, Macrocyclic, Rats, Versicans, ErbB Receptors

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Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth

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