SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity

The serial cultivation of human diploid cell strains

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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Telomeres shorten during ageing of human fibroblasts

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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

Um, J.-H., Park, S.-J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., Kim, M. K., Viollet, B., & Chung, J. H. (2010) · Diabetes · doi:10.2337/db09-0482 · Cited by 647

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., Fuchs, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002020 · Cited by 588

The molecular targets of resveratrol

Kulkarni, S. S., & Cantó, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.005 · Cited by 477

Sirtuins — novel therapeutic targets to treat age-associated diseases

Lavu, S., Boss, O., Elliott, P. J., & Lambert, P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2665 · Cited by 427

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

Pillai, V. B., Sundaresan, N. R., Kim, G. H., Gupta, M., Rajamohan, S. B., Pillai, J. B., Samant, S. A., Ravindra, P. A., Isbatan, A., & Gupta, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077271 · Cited by 424

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

Li, L., Wang, L., Li, L., Wang, Z., Ho, Y., McDonald, T., Holyoake, T. L., Chen, W., & Bhatia, R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.12.020 · Cited by 414

Vascular endothelial senescence: from mechanisms to pathophysiology

Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

Ghosh, H. S., McBurney, M., & Robbins, P. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009199 · Cited by 397

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

Sundaresan, N. R., Pillai, V. B., Wolfgeher, D., Samant, S. A., Vasudevan, P., Parekh, V., Raghuraman, H., Cunningham, J. M., Gupta, M., & Gupta, M. P. (2011) · Science Signaling · doi:10.1126/scisignal.2001465 · Cited by 352

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

Zu, Y., Liu, L., Lee, M. Y. K., Xu, C., Liang, Y., Man, R. Y., Vanhoutte, P. M., & Wang, Y. (2010) · Circulation Research · doi:10.1161/circresaha.109.215483 · Cited by 303

Dietary Amino Acids and the Gut‐Microbiome‐Immune Axis: Physiological Metabolism and Therapeutic Prospects

Ma, N., & Ma, X. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12401 · Cited by 285

Sirtuins in Epigenetic Regulation

Jing, H., & Lin, H. (2015) · Chemical Reviews · doi:10.1021/cr500457h · Cited by 276

SIRT1 contributes to telomere maintenance and augments global homologous recombination

Palacios, J., Herranz, D., Bonis, M. L. D., Velasco, S., Serrano, M., & Blasco, M. A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201005160 · Cited by 263

A c-Myc–SIRT1 feedback loop regulates cell growth and transformation

Yuan, J., Minter‐Dykhouse, K., & Lou, Z. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200809167 · Cited by 233

Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment

Peled, T., Shoham, H., Aschengrau, D., Yackoubov, D., Frei, G. M., Rosenheimer, N. G., Lerrer, B., Cohen, H. Y., Nagler, A., Fibach, E., et al. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2011.12.005 · Cited by 205

Activation of Stress Response Gene SIRT1 by BCR-ABL Promotes Leukemogenesis

Yuan, H., Wang, Z., Li, L., Zhang, H., Modi, H., Horne, D., Bhatia, R., & Chen, W. (2012) · Blood · doi:10.1182/blood-2011-06-361691 · Cited by 182

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate

Rafalski, V. A., Mancini, E., & Brunet, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.114827 · Cited by 181

SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice

Li, L., Zhang, H.-N., Chen, H., Gao, P., Zhu, L.-H., Li, H.-L., Lv, X., Zhang, Q.-J., Zhang, R., Wang, Z., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.237875 · Cited by 180

SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

Wang, Y., Liang, Y. Q., & Vanhoutte, P. M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.047 · Cited by 178

SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation

Hayakawa, T., Iwai, M., Aoki, S., Takimoto, K., Maruyama, M., Maruyama, W., & Motoyama, N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116480 · Cited by 170

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling

Guo, W., Qian, L., Zhang, J., Zhang, W., Morrison, A., Hayes, P. D., Wilson, S., Chen, T., & Zhao, J. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22725 · Cited by 163

SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer

Kabra, N., Li, Z., Chen, L., Li, B., Zhang, X. M., Wang, C., Yeatman, T. J., Coppola, D., & Chen, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000034 · Cited by 160

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

Mihaylova, M. M., Sabatini, D. M., & Yilmaz, Ö. H. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.008 · Cited by 158

Diphosphoinositol Polyphosphates: Metabolic Messengers?

Shears, S. B. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.055897 · Cited by 152

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

Rimmelé, P., Bigarella, C. L., Liang, R. H.-S., Izac, B., Dieguez‐Gonzalez, R., Barbet, G., Donovan, M. J., Brugnara, C., Blander, J. M., Sinclair, D. A., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.015 · Cited by 154

Epigenetic regulation of aging stem cells

Pollina, E. A., & Brunet, A. (2011) · Oncogene · doi:10.1038/onc.2011.45 · Cited by 111

SIRT1 is required for long-term growth of human mesenchymal stem cells

Yuan, H., Zhai, C., Yan, X., Zhao, D., Wang, J., Zeng, Q., Chen, L., Nan, X., He, L., Li, S.-T., et al. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0825-4 · Cited by 129

Air Pollution Stress and the Aging Phenotype: The Telomere Connection

Martens, D. S., & Nawrot, T. S. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0098-8 · Cited by 132

Sirtuins in stress response: guardians of the genome

Bosch‐Presegué, L., & Vaquero, A. (2013) · Oncogene · doi:10.1038/onc.2013.344 · Cited by 126

The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease

Jayasena, T., Poljak, A., Smythe, G. A., Braidy, N., Münch, G. W., & Sachdev, P. S. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.06.003 · Cited by 122

SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

Chen, H., Liu, X., Zhu, W., Chen, H., Hu, X., Jiang, Z., Xu, Y., Wang, L., Zhou, Y., Chen, P., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00103 · Cited by 119

The conserved role of sirtuins in chromatin regulation

Vaquero, A. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082675av · Cited by 119

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

Chen, J., Xavier, S., Moskowitz-Kassai, E., Chen, R., Lu, C. Y., Sanduski, K., Špes, A., Turk, B., & Goligorsky, M. S. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.033 · Cited by 116

Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

Singh, S. K., Williams, C. A., Klarmann, K. D., Burkett, S. S., Keller, J. R., & Oberdoerffer, P. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121608 · Cited by 107

SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

Ou, X., Chae, H.-D., Wang, R., Shelley, W. C., Cooper, S. H., Taylor, T. M., Kim, Y., Deng, C., Yöder, M. C., & Broxmeyer, H. E. (2010) · Blood · doi:10.1182/blood-2010-03-273011 · Cited by 104

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice

Mojiri, A., Walther, B. K., Jiang, C., Matrone, G., Holgate, R., Xu, Q., Morales, E., Wang, G., Gu, J., Wang, R., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab547 · Cited by 97

AMPK: a master energy regulator for gonadal function

Bertoldo, M. J., Faure, M., Dupont, J., & Froment, P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00235 · Cited by 94

Hot topics in epigenetic mechanisms of aging: 2011

Berdasco, M., & Esteller, M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00806.x · Cited by 86

SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced

Ho, C., van der Veer, E., Akawi, O., & Pickering, J. G. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.08.031 · Cited by 85

Sirtuin 1: A Target for Kidney Diseases

Kong, L., Wu, H., Zhou, W., Luo, M., Tan, Y., Miao, L., & Cai, L. (2015) · Molecular Medicine · doi:10.2119/molmed.2014.00211 · Cited by 83

Physical Activity and Telomere Biology: Exploring the Link with Aging-Related Disease Prevention

Ludlow, A. T., & Roth, S. M. (2011) · Journal of Aging Research · doi:10.4061/2011/790378 · Cited by 80

Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect

Giovannini, L., & Bianchi, S. E. (2016) · Nutrition · doi:10.1016/j.nut.2016.09.008 · Cited by 79

Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells

Chauhan, D., Bandi, M. L., Singh, A., Ray, A., Raje, N. S., Richardson, P. G. G., & Anderson, K. C. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08888.x · Cited by 78

Advances in umbilical cord blood manipulation—from niche to bedside

Lund, T. C., Boitano, A. E., Delaney, C. S., Shpall, E. J., & Wagner, J. E. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.215 · Cited by 74

SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells

Bonis, M. L. D., Ortega, S., & Blasco, M. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.03.002 · Cited by 74

Silent information regulator, Sirtuin 1, and age‐related diseases

Zeng, L., Chen, R., Liang, F.-X., Tsuchiya, H., Murai, H., Nakahashi, T., Iwai, K., Takahashi, T., Kanda, T., & Morimoto, S. (2009) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2008.00504.x · Cited by 72

Sirtuin-3 (SIRT3) and the Hallmarks of Cancer

Alhazzazi, T. Y., Kamarajan, P., Verdin, E. M., & Kapila, Y. L. (2013) · Genes & Cancer · doi:10.1177/1947601913486351 · Cited by 69

Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors

Bao, J., & Sack, M. N. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0402-y · Cited by 67

An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds

Fusi, J., Bianchi, S. E., Daniele, S., Pellegrini, S., Martini, C., Galetta, F., Giovannini, L., & Franzoni, F. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.006 · Cited by 70

Sirtuin 1, stem cells, aging, and stem cell aging

Mantel, C., & Broxmeyer, H. E. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283043819 · Cited by 65

Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance

Feng, A. N., Zhang, L. H., Fan, X., Huang, Q. M., Ye, Q., Wu, H. Y., & Yang, J. (2011) · International Journal of Surgical Pathology · doi:10.1177/1066896911412181 · Cited by 63

Nicotinamide Phosphoribosyl Transferase (Nampt) Is Required for De Novo Lipogenesis in Tumor Cells

Bowlby, S. C., Thomas, M. J., D’Agostino, R. B., & Kridel, S. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040195 · Cited by 54

Impact of circadian disruption on health; SIRT1 and Telomeres

Osum, M., & Serakıncı, N. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102993 · Cited by 51

Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms

El‐Ashmawy, N. E., Khedr, N. F., El‐Bahrawy, H. A., & Mansour, H. E. A. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1382-6 · Cited by 50

Sirtuins, Bioageing, and Cancer

McGuinness, D. H., McGuinness, D. H., McCaul, J. A., & Shiels, P. G. (2011) · Journal of Aging Research · doi:10.4061/2011/235754 · Cited by 48

Novel Techniques for Ex Vivo Expansion of Cord Blood: Clinical Trials

Mehta, R. S., Rezvani, K., Olson, A. L., Oran, B., Hosing, C. M., Shah, N. D., Parmar, S., Armitage, S. K., & Shpall, E. J. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00089 · Cited by 47

SIRT1 activates the expression of fetal hemoglobin genes

Dai, Y., Chen, T., Ijaz, H., Cho, E. H., & Steinberg, M. H. (2017) · American Journal of Hematology · doi:10.1002/ajh.24879 · Cited by 47

BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in vivo

Wang, Y., Zhang, G., Jiang, F., Zeng, Y., Zou, P., An, H., Chen, Q., Ling, X., Han, F., Liu, W., et al. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.05.004 · Cited by 44

Molecular responses in the telomere-mitochondrial axis of ageing in the elderly: A candidate gene approach

Pieters, N., Janssen, B. G., Valeri, L., Cox, B., Cuypers, A., Dewitte, H., Plusquin, M., Smeets, K., & Nawrot, T. S. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.003 · Cited by 43

SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

Peng, C., Chang, Y.-L., Kao, C.-L., Tseng, L.-M., Wu, C.-C., Chen, Y., Tsai, C.-Y., Woung, L., Liu, J., Chiou, S., et al. (2010) · Sensors · doi:10.3390/s100606172 · Cited by 42

Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains

Merrick, C. J., Jiang, R. H. Y., Skillman, K. M., Samarakoon, U., Moore, R. M., Dzikowski, R., Ferdig, M. T., & Duraisingh, M. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118865 · Cited by 38

Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway

Ma, L., Wang, R., Dong, W., & Zhao, Z. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.013 · Cited by 38

Medical genetics and epigenetics of telomerase

Koziel, J. E., Fox, M. J., Steding, C. E., Sprouse, A. A., & Herbert, B. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01276.x · Cited by 37

Metabolism, longevity and epigenetics

Cosentino, C., & Mostoslavsky, R. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1295-3 · Cited by 35

Roles of SIRT1 in leukemogenesis

Chen, W., & Bhatia, R. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328360ab64 · Cited by 34

Novel chemical attempts at ex vivo hematopoietic stem cell expansion

Zhang, Y., & Gao, Y. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-1962-x · Cited by 33

Sirtuins in Hematological Aging and Malignancy

Roth, M., Wang, Z., & Chen, W. (2013) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2013010187 · Cited by 31

Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis

Zhao, T., Li, Y., Liu, B., Bronson, R. T., Halaweish, I. F., & Alam, H. B. (2014) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000000347 · Cited by 30

SIRT1 inhibits the mouse intestinal motility and epithelial proliferation

Wang, Y., Shi, X., Qi, J., Li, X., Uray, K., & Guan, X. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00302.2011 · Cited by 29

Regulatory RNA-binding proteins in senescence

Wang, W. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.006 · Cited by 27

Engineering cord blood to improve engraftment after cord blood transplant

Mehta, R. S., Dave, H., Bollard, C. M., & Shpall, E. J. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.05.01 · Cited by 26

Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators

Bianchi, S. E., & Giovannini, L. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1446093 · Cited by 20

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in theSIRT1gene

Han, J., Hubbard, B. P., Lee, J. H., Montagna, C., Lee, H., Sinclair, D. A., & Suh, Y. (2013) · Cell Cycle · doi:10.4161/cc.23056 · Cited by 20

Metabolism and cancer: an up-to-date review of a mutual connection.

Mentis, A. A., & Kararizou, E. G. (2010) · PubMed · Cited by 20

Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

Wang, Z., Zhang, C., Warden, C., Liu, Z., Yuan, Y., Guo, C., Wang, C., Wang, J., Wu, X., Ermel, R. W., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03340-w · Cited by 19

Mechanisms of melatonin in anti-aging and its regulation effects in radiation-induced premature senescence

Ma, L., Liu, Q.-J., Tian, M., Tian, X.-L., & Gao, L. (2021) · Radiation Medicine and Protection · doi:10.1016/j.radmp.2021.01.003 · Cited by 15

AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase

Jo, D., Park, R., Kim, H.-J., Jang, M., Lee, E., Jang, I., & Park, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207864 · Cited by 15

Sirtuins in Aging and Age-Related Diseases

Haigis, M. C., & Sinclair, D. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00011-7 · Cited by 13

Sirtuins, Tissue Maintenance, and Tumorigenesis

Mohrin, M., & Chen, D. (2013) · Genes & Cancer · doi:10.1177/1947601912474930 · Cited by 11

The green tea polyphenol EGCG is differentially associated with telomeric regulation in normal human fibroblasts versus cancer cells

Pointner, A., Mölzer, C., Magnet, U., Zappe, K., Hippe, B., Tosevska, A., Tomeva, E., Dum, E., Gessner, D., Lilja, S., et al. (2021) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v11i3.775 · Cited by 15

CD150− Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1

Wang, Z., Chen, C., & Chen, W. (2015) · Stem Cells · doi:10.1002/stem.2218 · Cited by 12

Dual regulation of TERT activity through transcription and splicing by ΔNP63α

Vorovich, E. B., & Ratovitski, E. A. (2008) · Aging · doi:10.18632/aging.100003 · Cited by 10

Therapeutically relevant natural products as AMPK activators in the treatment of diabetes

Germán-Acacio, J. M., Meza-Sánchez, D. E., & Morales‐Morales, D. (2020) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817907-9.00003-9 · Cited by 10

Therapeutic targeting and HSC proliferation by small molecules and biologicals

Albayrak, E., & Kocabaş, F. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2022.11.012 · Cited by 5

Respected Sir(2): magic target for diabetes.

Nerurkar, P. V., & Nerurkar, V. R. (2008) · PubMed · Cited by 4

Metadichol® a Sirtuin Modulator for Anti-Aging TherapiesPreprint

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Nesfatin-1 attenuated lipopolysaccharide-induced inflammatory response and senescence in human dental pulp cells

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