SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells
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RATIONALE: Endothelial senescence causes endothelial dysfunction, promotes atherogenesis and contributes to age-related vascular disorders. SIRT1 is a conserved NAD(+)-dependent deacetylase possessing beneficial effects against aging-related diseases, despite that the detailed functional mechanisms are largely uncharacterized. OBJECTIVE: The present study is designed to evaluate the protective effects of SIRT1 on endothelial senescence and to elucidate the underlying mechanisms. METHODS AND RESULTS: An in vitro senescence model was established by prolonged culture of primary endothelial cells isolated from porcine aorta. The freshly isolated "young" cells gradually underwent senescence during 1 month of repetitive passages. Both mRNA and protein expressions of SIRT1 were progressively decreased. In contrast, the protein levels of LKB1, a serine/threonine kinase and tumor suppressor, and the phosphorylation of its downstream target AMPK(Thr172) were dramatically increased in senescent cells. Overexpression of LKB1 promoted cellular senescence and retarded endothelial proliferation, which could be blocked by increasing SIRT1 levels. Knocking down of SIRT1 induced senescence and elevated the protein levels of LKB1 and phosphorylated AMPK(Thr172). Regardless of the nutritional status, hyperactivation of AMPK was able to induce endothelial senescence. SIRT1 antagonized LKB1-dependent AMPK activation through promoting the deacetylation, ubiquitination and proteasome-mediated degradation of LKB1. The survival signaling of Akt was also found to be modulated by SIRT1 and LKB1, and could cross-regulate AMPK activity. CONCLUSIONS: SIRT1 and LKB1/AMPK are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence. The protective activities of SIRT1 may be achieved at least in part by fine tuning the acetylation/deacetylation status and stabilities of LKB1 protein.
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Sirtuin-1 promotes endothelial cell proliferation and suppresses senescence of porcine primary aortic endothelial cells via a signaling mechanism requiring expression of LKB1, the upstream regulator of AMPK.
“Sirtuin-1 also has been reported to promote endothelial cell proliferation and suppress senescence of porcine primary aortic endothelial cells via a signaling mechanism requiring the expression of the serine-threonine kinase, LKB1, the upstream regulator of AMPK (179).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [179]
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- Authors
- Zu, Y., Liu, L., Lee, M. Y. K., Xu, C., Liang, Y., Man, R. Y., Vanhoutte, P. M., & Wang, Y.
- Affiliations
- University of Hong Kong (HK)
- Venue
- Circulation Research
- Published
- 2010-04-30
- Volume
- 106
- Issue
- 8
- Pages
- 1384-1393
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1964041100
- Cited by
- 303
- References
- 48
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 11 · 2023: 13 · 2022: 25 · 2021: 19 · 2020: 21 · 2019: 15 · 2018: 23 · 2017: 16 · 2016: 19 · 2015: 24 · 2014: 25 · 2013: 20 · 2012: 28
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- SIRT1, LKB1, AMPK, endothelial cell senescence, endothelial cell proliferation, endothelial cell survival, protein deacetylation, ubiquitination, proteasomal degradation, Akt signaling, aortic endothelial cells, atherogenesis
- MeSH terms
- Acetylation, Animals, Aorta, Cell Survival, Cells, Cultured, Enzyme Activation, Female, Genotype, Humans, Injections, Intraperitoneal, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Paraquat, Phenotype, Phosphorylation, Protein Processing, Post-Translational, RNA, Messenger, Swine, Threonine, Time Factors, Transfection, Signal Transduction, Down-Regulation, Up-Regulation, Cellular Senescence, Protein Serine-Threonine Kinases, RNA Interference, Endothelial Cells, Proteasome Endopeptidase Complex, Cell Proliferation, Proto-Oncogene Proteins c-akt, Mice, Ubiquitination, AMP-Activated Protein Kinases, Sirtuin 1
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