Hot topics in epigenetic mechanisms of aging: 2011
Open accessAbstract
Summary: Aging is a complex process that results in compromised biological functions of the organism and increased susceptibility to disease and death. Although the molecular basis of aging is currently being investigated in many experimental contexts, there is no consensus theory to fully explain the aging process. Epigenetic factors, including DNA methylation, histone modifications, and microRNA expression, may play central roles in controlling changes in gene expression and genomic instability during aging. In this Hot Topic review, we first examine the mechanisms by which these epigenetic factors contribute to aging in diverse eukaryotic species including experimental models of yeasts, worms, and mammals. In a second section, we will emphasize in the mammalian epigenetic alterations and how they may affect human longevity by altering stem cell function and/or somatic cell decline. The field of aging epigenetics is ripe with potential, but is still in its infancy, as new layers of complexity are emerging in the epigenetic network. As an example, we are only beginning to understand the relevance of non‐coding genome to organism aging or the existence of an epigenetic memory with transgenerational inheritance. Addressing these topics will be fundamental for exploiting epigenetics phenomena as markers of aging‐related diseases or as therapeutic targets.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Over time, exposure to an inflammatory milieu might induce epigenetic modifications that alter expression of genes needed for growth, survival, or differentiation.
“For example, over time exposure to an inflammatory milieu might induce epigenetic modifications that affect the expression of genes required for growth, survival, or differentiation (89,90).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [89]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Fasano, C. A., Dimos, J. T., Ivanova, N. B., Lowry, N. A., Lemischka, I. R., & Temple, S. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.04.001 · Cited by 301 · see citing works
RetractedLagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works
Self-citationKaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1× · see citing works
“Sir2 prevents aging by translocating its complex from telomeres to ribosomal DNA repeats and avoiding the formation of extrachromosomal rDNA circles (ERCs) that could result in genomic instability (Kaeberlein et al., 1999).”
BackgroundIncreased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361 · see citing works
Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226 · see citing works
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · see citing works
Christensen, B. C., Houseman, E. A., Marsit, C. J., Zheng, S., Wrensch, M., Wiemels, J. L., Nelson, H. H., Karagas, M. R., Padbury, J. F., Bueno, R., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000602 · Cited by 1,062 · see citing works
Bocklandt, S., Lin, W., Sehl, M. E., Sánchez, F. J., Sinsheimer, J. S., Horvath, S., & Vilain, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014821 · Cited by 1,012 · see citing works
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
Vaquero, A., Scher, M., Lee, D., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.031 · Cited by 916 · see citing works
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
Teschendorff, A. E., Menon, U., Gentry-Maharaj, A., Ramus, S. J., Weisenberger, D. J., Shen, H., Campan, M., Noushmehr, H., Bell, C. G., Maxwell, A. P., et al. (2010) · Genome Research · doi:10.1101/gr.103606.109 · Cited by 855 · see citing works
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S.-K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.025 · Cited by 852 · see citing works
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development · doi:10.1101/gad.415507 · Cited by 850 · see citing works
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domainsPreprint
Rakyan, V. K., Down, T. A., Maslau, S., Andrew, T., Yang, T.-P., Beyan, H., Whittaker, P., McCann, O. T., Finer, S., Valdes, A. M., et al. (2010) · Genome Research · doi:10.1101/gr.103101.109 · Cited by 750 · see citing works
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science · doi:10.1126/science.1099593 · Cited by 750 · see citing works
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704 · see citing works
Intra-individual Change Over Time in DNA Methylation With Familial Clustering
Bjornsson, H. T. (2008) · JAMA · doi:10.1001/jama.299.24.2877 · Cited by 702 · see citing works
Histone H4 lysine 16 acetylation regulates cellular lifespan
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660 · see citing works
Sirtuins in aging and age-related disease
Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628 · see citing works
Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry
Berdasco, M., & Esteller, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.005 · Cited by 623 · see citing works
Self-citationDecline in genomic DNA methylation through aging in a cohort of elderly subjects
Bollati, V., Schwartz, J. D., Wright, R. O., Litonjua, A. A., Tarantini, L., Suh, H. H., Sparrow, D., Vokonas, P., & Baccarelli, A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.003 · Cited by 594 · see citing works
Widespread and tissue specific age-related DNA methylation changes in mice
Maegawa, S., Hinkal, G., Kim, H. S., Shen, L., Zhang, L., Zhang, J., Zhang, N., Liang, S., Donehower, L. A., & Issa, J.-P. J. (2010) · Genome Research · doi:10.1101/gr.096826.109 · Cited by 553 · see citing works
Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543 · see citing works
A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans
Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 449 · see citing works
A DNA methylation fingerprint of 1628 human samplesPreprint
Fernández, A. F., Assenov, Y., Martín-Subero, J. I., Bálint, B., Siebert, R., Taniguchi, H., Yamamoto, H., Hidalgo, M. M., Tan, A. C., Galm, O., et al. (2011) · Genome Research · doi:10.1101/gr.119867.110 · Cited by 415 · see citing works
Self-citationDNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells
Bork, S., Pfister, S. M., Witt, H., Horn, P., Korn, B., Ho, A. D., & Wagner, W. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00535.x · Cited by 411 · see citing works
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Hernandez, D. G., Nalls, M. A., Gibbs, J. R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D. L., Cookson, M., Traynor, B. J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq561 · Cited by 376 · see citing works
Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
Waterland, R. A., Lin, J.-R., Smith, C. A., & Jirtle, R. L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi484 · Cited by 337 · see citing works
Sandovici, I., Smith, N. H., Nitert, M. D., Ackers-Johnson, M., Uribe-Lewis, S., Ito, Y., Jones, R. H., Marquez, V. E., Cairns, W., Tadayyon, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019007108 · Cited by 326 · see citing works
Regenerative potential of human skeletal muscle during aging
Renault, V. M., Thorne, L., Eriksson, P., Butler-Browne, G. S., & Mouly, V. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00017.x · Cited by 318 · see citing works
Galm, O., Yoshikawa, H., Esteller, M., Osieka, R., & Herman, J. G. (2003) · Blood · doi:10.1182/blood-2002-06-1735 · Cited by 308 · see citing works
Self-citationAging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin
Grönniger, E., Weber, B., Heil, O., Peters, N., Stäb, F., Wenck, H., Korn, B., Winnefeld, M., & Lyko, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000971 · Cited by 275 · see citing works
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
Agrelo, R., Cheng, W.-H., Setien, F., Ropero, S., Espada, J., Fraga, M. F., Herranz, M., Paz, M. F., Sanchez-Cespedes, M., Artiga, M. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600645103 · Cited by 264 · see citing works
Self-citationJin, C., Li, J., Green, C. D., Yu, X., Tang, X., Han, D., Xian, B., Wang, D., Huang, X., Cao, X., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.001 · Cited by 258 · see citing works
Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256 · see citing works
Sarg, B., Koutzamani, E., Helliger, W., Rundquist, I., & Lindner, H. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205166200 · Cited by 252 · see citing works
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
Ugalde, A. P., Ramsay, A. J., Rosa, J. D. L., Varela, I., Mariño, G., Cadiñanos, J., Lü, J., Freije, J. M. P., & López-Otı́n, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.124 · Cited by 252 · see citing works
Histone H3-K56 acetylation is important for genomic stability in mammals
Yuan, J., Pu, M., Zhang, Z., & Lou, Z. (2009) · Cell Cycle · doi:10.4161/cc.8.11.8620 · Cited by 247 · see citing works
Krishnan, V., Chow, M. Z. Y., Wang, Z., Zhang, L., Liu, B., Liu, X., & Zhou, Z. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102789108 · Cited by 236 · see citing works
Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis
Drummond, M. J., McCarthy, J. J., Sinha, M., Spratt, H. M., Volpi, E., Esser, K. A., & Rasmussen, B. B. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00148.2010 · Cited by 233 · see citing works
Age-Related DNA Methylation Changes in Normal Human Prostate Tissues
Kwabi‐Addo, B., Chung, W., Shen, L., Ittmann, M., Wheeler, T. M., Jelı́nek, J., & Issa, J. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0085 · Cited by 213 · see citing works
Bocker, M., Hellwig, I., Breiling, A., Eckstein, V., Ho, A. D., & Lyko, F. (2011) · Blood · doi:10.1182/blood-2011-01-331926 · Cited by 195 · see citing works
Murine microRNAs implicated in liver functions and aging process
Maes, O. C., An, J., Sarojini, H., & Wang, E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.05.004 · Cited by 193 · see citing works
Modulated microRNA expression during adult lifespan in Caenorhabditis elegans
Ibáñez‐Ventoso, C., Yang, M., Guo, S., Robins, H. S., Padgett, R. W., & Driscoll, M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00210.x · Cited by 193 · see citing works
Oguro, H., Yuan, J., Ichikawa, H., Ikawa, T., Yamazaki, S., Kawamoto, H., Nakauchi, H., & Iwama, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.01.005 · Cited by 186 · see citing works
DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs
So, A.-Y., Jung, J., Lee, S., Kim, H., & Kang, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019503 · Cited by 180 · see citing works
Apoptosis and aging: increased resistance to apoptosis enhances the aging process
Salminen, A., Ojala, J., & Kaarniranta, K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0597-y · Cited by 158 · see citing works
Schneider, E., Pliushch, G., Hajj, N. E., Galetzka, D., Puhl, A., Schorsch, M., Frauenknecht, K., Riepert, T., Tresch, A., Müller, A. M., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq126 · Cited by 132 · see citing works
Epigenetic regulation of aging stem cells
Pollina, E. A., & Brunet, A. (2011) · Oncogene · doi:10.1038/onc.2011.45 · Cited by 128 · see citing works
So, K., Tamura, G., Honda, T., Homma, N., Waki, T., Togawa, N., Nishizuka, S., & Motoyama, T. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00302.x · Cited by 122 · see citing works
Narala, S. R., Allsopp, R. C., Wells, T. B., Zhang, G., Prasad, P., Coussens, M. J., Rossi, D. J., Weissman, I. L., & Vaziri, H. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0965 · Cited by 106 · see citing works
Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks
Kawahara, T. L. A., Rapicavoli, N. A., Wu, A. R., Qu, K., Quake, S. R., & Chang, H. Y. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002153 · Cited by 101 · see citing works
Lee, S., Jung, J.-W., Park, S., Roh, K.-H., Lee, S. Y., Kim, J. H., Kang, S.-K., & Kang, K. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0457-9 · Cited by 101 · see citing works
MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging
Bates, D. J., Li, N., Liang, R., Sarojini, H., An, J., Masternak, M. M., Bartke, A., & Wang, E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00529.x · Cited by 97 · see citing works
Aging in the lympho-hematopoietic stem cell compartment
Geiger, H., & Rudolph, K. L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.010 · Cited by 97 · see citing works
Sommer, M., Poliak, N., Upadhyay, S. K., Ratovitski, E. A., Nelkin, B. D., Donehower, L. A., & Sidransky, D. (2006) · Cell Cycle · doi:10.4161/cc.5.17.3194 · Cited by 86 · see citing works
Bonifacio, L. N., & Jarstfer, M. B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012519 · Cited by 85 · see citing works
Osorio, F. G., Varela, I., Lara, E., Puente, X. S., Espada, J., Santoro, R., Freije, J. M. P., Fraga, M. F., & López-Otı́n, C. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00621.x · Cited by 69 · see citing works
Hachinohe, M., Hanaoka, F., & Masumoto, H. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01493.x · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works
Obesity accelerates epigenetic aging of human liver
Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., Schönfels, W. V., Ahrens, M., Heits, N., Bell, J. T., Tsai, P.-C., Spector, T. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412759111 · Cited by 760 · see citing works
Dynamic DNA methylation: In the right place at the right time
Luo, C., Hajkova, P., & Ecker, J. R. (2018) · Science · doi:10.1126/science.aat6806 · Cited by 668 · see citing works
The ageing haematopoietic stem cell compartment
Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604 · see citing works
Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
Gems, D., & Partridge, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 545 · see citing works
Methylation of <scp> <i>ELOVL</i> </scp> <i>2</i> gene as a new epigenetic marker of age
Garagnani, P., Bacalini, M. G., Pirazzini, C., Gori, D., Giuliani, C., Mari, D., Di Blasio, A. M., Gentilini, D., Vitale, G., Collino, S., et al. (2012) · Aging Cell · doi:10.1111/acel.12005 · Cited by 473 · see citing works
Oxidative damage, ageing, and life-history evolution: where now?
Selman, C., Blount, J. D., Nussey, D. H., & Speakman, J. R. (2012) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2012.06.006 · Cited by 385 · see citing works
Epigenetic estimation of age in humpback whales
Polanowski, A. M., Robbins, J., Chandler, D., & Jarman, S. (2014) · Molecular Ecology Resources · doi:10.1111/1755-0998.12247 · Cited by 184 · see citing works
Cole, J. J., Robertson, N., Rather, M. I., Thomson, J. P., McBryan, T., Sproul, D., Wang, T., Brock, C., Clark, W. A., Ideker, T. E., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1185-3 · Cited by 182 · see citing works
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
Adams, P. D., Jasper, H., & Rudolph, K. L. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.002 · Cited by 179 · see citing works
Cellular Senescence as the Causal Nexus of Aging
Bhatia‐Dey, N., Kanherkar, R. R., Stair, S. E., Makarev, E., & Csoka, A. B. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00013 · Cited by 147 · see citing works
Epigenetic age signatures in the forensically relevant body fluid of semen: a preliminary study.
Lee, H., Jung, S.-E., Oh, Y. N., Choi, A., Yang, W., & Shin, K.-J. (2015) · Forensic Science International: Genetics · doi:10.1016/j.fsigen.2015.05.014 · Cited by 122 · see citing works
Kornicka, K., Marycz, K., Tomaszewski, K. A., Marędziak, M., & Śmieszek, A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/309169 · Cited by 137 · see citing works
Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population
Faye, C., McGowan, J. C., Denny, C. A., & David, D. J. P. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170818095105 · Cited by 137 · see citing works
Simino, J. M., Shi, G., Bis, J. C., Chasman, D. I., Ehret, G., Gu, X., Guo, X., Hwang, S., Sijbrands, E. J. G., Smith, A. V., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.05.010 · Cited by 132 · see citing works
Chromatin deregulation in disease
Mirabella, A., Foster, B. M., & Bartke, T. (2015) · Chromosoma · doi:10.1007/s00412-015-0530-0 · Cited by 132 · see citing works
DNA methylation: a promising landscape for immune system-related diseases.
Suárez-Álvarez, B., Rodríguez, R. M., Fraga, M., & López-Larrea, C. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.06.005 · Cited by 127 · see citing works
Recent advances in calorie restriction research on aging
Chung, K. W., Kim, D. H., Park, M. H., Choi, Y. J., Kim, N. D., Lee, J., Yu, B. P., & Chung, H. Y. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.007 · Cited by 108 · see citing works
Yan, X., Ehnert, S., Culmes, M., Bachmann, A., Seeliger, C., Schyschka, L., Wang, Z., Rahmanian‐Schwarz, A., Stöckle, U., Sousa, P. A. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090846 · Cited by 92 · see citing works
Influence of age on wound healing and fibrosis
Kapetanaki, M. G., Mora, A. L., & Rojas, M. M. (2012) · The Journal of Pathology · doi:10.1002/path.4122 · Cited by 90 · see citing works
Organ-Size Regulation in MammalsPreprint
Penzo‐Méndez, A., & Stanger, B. Z. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019240 · Cited by 78 · see citing works
Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q., & Su, D. (2018) · The FASEB Journal · doi:10.1096/fj.201800059r · Cited by 73 · see citing works
Bendale, D. S., Karpe, P. A., Chhabra, R., Shete, S. P., Shah, H., & Tikoo, K. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12290 · Cited by 74 · see citing works
Age‐associated alterations in the somatic mutation and DNA methylation levels in plants
Dubrovina, A. S., & Kiselev, K. V. (2015) · Plant Biology · doi:10.1111/plb.12375 · Cited by 72 · see citing works
Epigenetic Genome-Wide Association Methylation in Aging and Longevity
Ben‐Avraham, D., Muzumdar, R. H., & Atzmon, G. (2012) · Epigenomics · doi:10.2217/epi.12.41 · Cited by 68 · see citing works
The Mechanism of Bone Remodeling After Bone Aging
Fang, H., Deng, Z., Liu, J., Chen, S., Deng, Z., & Li, W. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s349604 · Cited by 70 · see citing works
Hibernation slows epigenetic ageing in yellow-bellied marmots
de Pinho, G. M., Martin, J. G. A., Farrell, C. P., Haghani, A., Zoller, J. A., Zhang, J., Snir, S., Pellegrini, M. A., Wayne, R. K., Blumstein, D. T., et al. (2022) · Nature Ecology & Evolution · doi:10.1038/s41559-022-01679-1 · Cited by 58 · see citing works
Epigenetic susceptibility factors for prostate cancer with aging
Damaschke, N., Yang, B., Bhusari, S. S., Svaren, J. P., & Jarrard, D. F. (2013) · The Prostate · doi:10.1002/pros.22716 · Cited by 55 · see citing works
Epigenetic drugs: a novel anti-aging strategy?
Vaiserman, A. M., & PASYUKOVA, E. G. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00224 · Cited by 53 · see citing works
Pavanello, S., Campisi, M., Tona, F., Lin, C. D., & Iliceto, S. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16173074 · Cited by 48 · see citing works
Forsberg, L. A., Absher, D., & Dumanski, J. P. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101322 · Cited by 44 · see citing works
Shi, D., Hu, L., Li, X., Liu, W., Gao, Y. J., Li, X., Jiang, B., Xia, C., Guo, Y., & Li, J. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128302 · Cited by 44 · see citing works
Using Epigenome-Wide Association Scans of DNA Methylation in Age-Related Complex Human Traits
Tsai, P.-C., Spector, T. D., & Bell, J. T. (2012) · Epigenomics · doi:10.2217/epi.12.45 · Cited by 41 · see citing works
Armstrong, V. L., Rakoczy, S. G., Rojanathammanee, L., & Brown-Borg, H. (2014) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/glt133 · Cited by 42 · see citing works
Garcez, M. L., de Carvalho, C. A., Mina, F., Bellettini-Santos, T., Schiavo, G. L., da Silva, S., Campos, A. C. B. F., Varela, R. B., Valvassori, S. S., Damiani, A. P., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.10.005 · Cited by 41 · see citing works
Understanding epigenetic changes in aging stem cells – a computational model approach
Przybilla, J., Rohlf, T., Loeffler, M., & Galle, J. (2014) · Aging Cell · doi:10.1111/acel.12177 · Cited by 40 · see citing works
Predicting human age by detecting DNA methylation status in hair
Hao, T., Guo, J., Liu, J., Wang, J., Liu, Z., Cheng, X., Li, J., Ren, J., Li, Z., Yan, J., et al. (2021) · Electrophoresis · doi:10.1002/elps.202000349 · Cited by 38 · see citing works
Sickle cell disease as an accelerated aging syndrome
Idris, I. M., Botchwey, E. A., & Hyacinth, H. I. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702211068522 · Cited by 37 · see citing works
Systemic milieu and age-related deterioration
Zhang, H., Cherian, R., & Jin, K. (2019) · GeroScience · doi:10.1007/s11357-019-00075-1 · Cited by 32 · see citing works
Liu, W., Lin, H., Mao, Z., Zhang, L., Bao, K., Jiang, B., Xia, C., Li, W.-J., Hu, Z., & Li, J. (2020) · Aging · doi:10.18632/aging.102951 · Cited by 34 · see citing works
Recent Advances in Epigenetics of Age-Related Kidney Diseases
Liu, F., Chen, J., Li, Z., & Meng, X. (2022) · Genes · doi:10.3390/genes13050796 · Cited by 29 · see citing works
Li, X., Tan, H., Zhou, S., Hu, S., Zhang, T., Li, Y., Dou, Q., Lai, Z., & Chen, F. (2016) · Scientific Reports · doi:10.1038/srep38030 · Cited by 29 · see citing works
Blank, M., Werenicz, A., Velho, L. A., Pinto, D. F., Fedi, A. C., Lopes, M. W., Peres, T. V., Leal, R. B., Dornelles, A. D. S., & Roesler, R. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.059 · Cited by 28 · see citing works
Iwaya, C., Kitajima, H., Yamamoto, K., Maeda, Y., Sonoda, N., Shibata, H., & Inoguchi, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.104 · Cited by 27 · see citing works
Endisha, H., Merrill, J. C., Zhao, M., Bristol, M. L., Wang, X., Kubben, N., & Elmore, L. W. (2015) · Pathobiology · doi:10.1159/000368856 · Cited by 22 · see citing works
A Fine-Tune Role of Mir-125a-5p on Foxn1 During Age-Associated Changes in the Thymus
Xu, M., Sizova, O. S., Wang, L., & Su, D. (2017) · Aging and Disease · doi:10.14336/ad.2016.1109 · Cited by 24 · see citing works
Editorial: Is It Time for Epigenetics in Osteoarthritis?
Blanco, F. J., & Rego‐Pérez, I. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38710 · Cited by 23 · see citing works
Role of oral fluids in DNA investigations
Pandeshwar, P., & Das, R. (2013) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2013.12.007 · Cited by 22 · see citing works
Simino, J. M., Wang, Z., Bressler, J., Chouraki, V. A., Yang, Q., Younkin, S. G., Seshadri, S. S., Fornage, M., Boerwinkle, E., & Mosley, T. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180046 · Cited by 20 · see citing works
Vámos, Z., Cséplő, P., Ivić, I. D., Mátics, R., Hamar, J., & Koller, Á. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt128 · Cited by 19 · see citing works
Ben-Avraham, D. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-2404-2_9 · Cited by 7 · see citing works
Florea, A. (2013) · BioMed Research International · doi:10.1155/2013/486072 · Cited by 18 · see citing works
Liuweidihuang Pill Alleviates Inflammation of the Testis via AMPK/SIRT1/NF-κB Pathway in Aging Rats
Wang, Y., Yang, Z., Yang, L.-L., Zou, Q., Zhao, S., Hu, N., Chen, D.-M., Cui, R., & Ma, H.-M. (2020) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2020/2792738 · Cited by 21 · see citing works
Left-Sided Early-Onset vs Late-Onset Colorectal Carcinoma
Pilozzi, E., Maresca, C., Duranti, E., Giustiniani, M. C., Catalanotto, C., Lucarelli, M., Cogoni, C., Ferri, M., Ruco, L., & Zardo, G. (2015) · American Journal of Clinical Pathology · doi:10.1309/ajcpnoc55iolxfud · Cited by 17 · see citing works
[Epigenetics, interface between environment and genes: role in complex diseases].
Scheen, A. J., & Junien, C. (2012) · PubMed · Cited by 15 · see citing works
Aging: Epigenetic modifications
Mishra, S., Raval, M., Kachhawaha, A. S., Tiwari, B. S., & Tiwari, A. K. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.02.002 · Cited by 14 · see citing works
Simino, J. M., Kume, R., Kraja, A. T., Turner, S. T., Hanis, C. L., Sheu, W. H., Chen, Y. I., Jaquish, C. E., Cooper, R., Chakravarti, A., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.008 · Cited by 13 · see citing works
The Epigenetic Regulation of Telomere Maintenance in Aging
Shekhidem, H. A., & Atzmon, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00005-x · Cited by 13 · see citing works
Forsberg, L. A., Absher, D., & Dumanski, J. P. (2013) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2012-101322rep · Cited by 11 · see citing works
Kopalli, S., Cha, K.-M., Cho, J., Kim, S.-K., & Koppula, S. (2022) · Mycobiology · doi:10.1080/12298093.2022.2035515 · Cited by 8 · see citing works
Comparative proteomics analysis of dietary restriction in Drosophila
Gao, Y., Zhu, C., Li, K., Cheng, X., Du, Y., Yang, D., Fan, X., Gaur, U., & Yang, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240596 · Cited by 9 · see citing works
Balducci, L. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-2865-7.00063-1 · Cited by 8 · see citing works
Hoseini, M., Sahmani, M., Foroughi, F., Monfared, Y. K., & Azad, M. (2019) · Europe PMC (PubMed Central) · Cited by 8 · see citing works
Hibernation slows epigenetic aging in yellow-bellied marmotsPreprint
de Pinho, G. M., Martin, J. G. A., Farrell, C. P., Haghani, A., Zoller, J. A., Zhang, J., Snir, S., Pellegrini, M. A., Wayne, R. K., Blumstein, D. T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.07.434299 · Cited by 5 · see citing works
Benmounah, Z., Meshoul, S., Batouche, M., & Lió, P. (2018) · Applied Soft Computing · doi:10.1016/j.asoc.2018.04.012 · Cited by 5 · see citing works
Life Extension in Drosophila by Histone Deacetylase Inhibitors
Vaiserman, A. M., & PASYUKOVA, E. G. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-18326-8_11 · Cited by 4 · see citing works
Feiner, L. K., Tierling, S., Holländer, S., Glanemann, M., & Rubie, C. (2021) · Aging · doi:10.18632/aging.202621 · Cited by 3 · see citing works
Epigenetic drugs based on antiaging approach: an overview
Minocha, T., Dwivedi, N., Panda, C., Misra, A., Nayak, B. B., Yadav, S. K., Birla, H., & Singh, S. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00011-2 · Cited by 2 · see citing works
Li, H., Lin, S., Qi, P., Wang, J., Fan, M., Hongwei, H., Dong, Z., Xu, K., & Guo, B. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.995691 · Cited by 3 · see citing works
Circulating Biomarkers of Aging
Zhang, H., Wang, B. Z., & Jin, K. (2019) · Healthy ageing and longevity · doi:10.1007/978-3-030-24970-0_21 · Cited by 2 · see citing works
Aging and IPF: What Is the Link?
Selman, M., Romero, Y., & Pardo, A. (2014) · Humana Press eBooks · doi:10.1007/978-1-62703-682-5_12 · Cited by 2 · see citing works
Epigenetic Alterations in Aging and Aging-Associated Diseases: Review
Gunes, S. O., & Bayramov, B. (2016) · Turkiye Klinikleri Journal of Medical Sciences · doi:10.5336/medsci.2016-51843 · Cited by 2 · see citing works
Faress, F., Ameri, M., Mojbafan, M., Aminifard, M. N., & Marashi, S. M. (2023) · International Journal of Medical Toxicology and Forensic Medicine · doi:10.32598/ijmtfm.v13i1.39298 · Cited by 2 · see citing works
Nussler, A. K., & Sajadian, S. O. (2015) · doi:10.1002/9781118540640.ch1 · Cited by 2 · see citing works
Traces of Life’s Experiences: Epigenetics (DNA methylation) in Forensics
Ghai, M., Evans, D. L., & Joshi, S. V. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_14 · Cited by 1 · see citing works
Aging mechanisms and rejuvenation strategies for hematopoietic stem cells
Zhang, Y., Xu, Y., Shi, W., Cao, D., Guo, D.-A., & Yue, R. (2026) · Genome biology · doi:10.1186/s13059-026-04119-6 · Cited by 1 · see citing works
Epigenetic-Processes Driven Disorders and Therapeutics
Thumoju, S., & Mohan, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812215-0.00018-2 · Cited by 1 · see citing works
Epigenetic processes–driven disorders and therapeutics
Mohan, V., Thumoju, S., & Mohiuddin, M. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-21863-7.00001-9 · Cited by 1 · see citing works
Guo, B., Lin, S., Qi, P., & Fan, M. (2021) · Research Square · doi:10.21203/rs.3.rs-155588/v1 · Cited by 1 · see citing works
Breast Cancer Biomarkers for Risk Assessment, Screening, Detection, Diagnosis, and Prognosis
Verma, M., & Barh, D. (2014) · Springer eBooks · doi:10.1007/978-81-322-0843-3_20
Pereira, V. S. (2013) · Americanae (AECID Library)
Epigenetic modifications in caloric restriction associated with longevity: A review of evidence
Zand, H., & Sedaghat, F. (2015)
Traces of Life’s Experiences: Epigenetics (DNA methylation) in Forensics
Ghai, M., Evans, D. L., & Joshi, S. V. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_14-1
Post-zygotic Genetic Variation in Health and Disease
Razzaghian, H. R. (2013) · Uppsala University Publications (Uppsala University)
Salud y envejecimiento situación actual, retos y propuestas
Acosta, I., Suárez", I. N. D. N. Y. N. ". V., Cordero, R. Á., de Medicina, U. N. A. D. M. (., Góngora, A. A., Suárez", I. N. D. N. Y. N. ". V., Morales, N. A., Suárez", I. N. D. N. Y. N. ". V., Rueda, C. A., de Durango, U. J., et al. (2013) · Universidad Nacional Autónoma de México, Secretaría de Desarrollo Institucional, Seminario sobre Medicina y Salud eBooks · doi:10.22201/sdi.9786070248597p.2013
- Authors
- Berdasco, M., & Esteller, M.
- Affiliations
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Esteller, Manel
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2012-03-15
- Volume
- 11
- Issue
- 2
- Pages
- 181-186
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC3490364
- OpenAlex
- W1565438120
- Cited by
- 86
- References
- 63
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 13 · 2014: 9 · 2013: 13 · 2012: 11
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, epigenetics, DNA methylation, histone modifications, microRNA expression, genomic instability, stem cell function, human longevity, non-coding genome, epigenetic memory, transgenerational inheritance, age-related diseases, aging models
- MeSH terms
- Aging, Animals, Cell Differentiation, Humans, Cellular Senescence, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
