The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates
Open accessAbstract
Chromosome segregation during mitosis requires the assembly of a large proteinaceous structure termed the kinetochore. In Caenorhabditis elegans, KNL-1 is required to target multiple outer kinetochore proteins. Here, we demonstrate that the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins. However, unlike in C. elegans, depletion of vertebrate KNL1 does not abolish kinetochore localization of the microtubule-binding Ndc80 complex. Instead, we show that KNL1 and CENP-K, a subunit of a constitutively centromere-associated complex that is missing from C. elegans, coordinately direct Ndc80 complex localization. Simultaneously reducing both hKNL1 and CENP-K function abolishes all aspects of kinetochore assembly downstream of centromeric chromatin and causes catastrophic chromosome segregation defects. These findings explain discrepancies in kinetochore assembly pathways between different organisms and reveal a surprising plasticity in the assembly mechanism of an essential cell division organelle.
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Citations
Cites
ZW10 links mitotic checkpoint signaling to the structural kinetochore
Kops, G. J. P. L., Kim, Y., Weaver, B. A. A., Mao, Y., McLeod, I., Yates, J. R., Tagaya, M., & Cleveland, D. W. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411118 · Cited by 249
Cited by
A Molecular View of Kinetochore Assembly and Function
Musacchio, A., & Desai, A. (2017) · Biology · doi:10.3390/biology6010005 · Cited by 544
Self-citationWelburn, J. P. I., Vleugel, M., Liu, D., Yates, J. R., Lampson, M. A., Fukagawa, T., & Cheeseman, I. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.034 · Cited by 481
Self-citationLiu, D., Vleugel, M., Backer, C. B., Hori, T., Fukagawa, T., Cheeseman, I. M., & Lampson, M. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001006 · Cited by 369
Self-citationProtein Architecture of the Human Kinetochore Microtubule Attachment Site
Wan, X., O'Quinn, R. P., Pierce, H. L., Joglekar, A. P., Gall, W. E., DeLuca, J. G., Carroll, C. W., Liu, S.-T., Yen, T. J., McEwen, B. F., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.035 · Cited by 334
Self-citationCentromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N
Carroll, C. W., Silva, M. C. C., Godek, K. M., Jansen, L. E. T., & Straight, A. F. (2009) · Nature Cell Biology · doi:10.1038/ncb1899 · Cited by 291
Metadata
- Authors
- Cheeseman, I. M., Hori, T., Fukagawa, T., & Desai, A.
- Venue
- Molecular Biology of the Cell
- Published
- 2008-02
- Volume
- 19
- Issue
- 2
- Pages
- 587-594
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2165962940
- Cited by
- 192
- References
- 1
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheeseman, I. M., Hori, T., Fukagawa, T., & Desai, A. (2008). KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e07-10-1051
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