The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of LPA4/p2y9/GPR23 in Negative Regulation of Cell Motility
Open accessAbstract
Lysophosphatidic acid (LPA) is a ligand of multiple G protein–coupled receptors. The LPA 1–3 receptors are members of the endothelial cell differentiation gene (Edg) family. LPA 4/p2y9/GPR23, a member of the purinergic receptor family, and recently identified LPA 5/GPR92 and p2y5 are structurally distant from the canonical Edg LPA receptors. Here we report targeted disruption of lpa 4 in mice. Although LPA 4-deficient mice displayed no apparent abnormalities, LPA 4-deficient mouse embryonic fibroblasts (MEFs) were hypersensitive to LPA-induced cell migration. Consistent with negative modulation of the phosphatidylinositol 3 kinase pathway by LPA 4, LPA 4 deficiency potentiated Akt and Rac but decreased Rho activation induced by LPA. Reconstitution of LPA 4 converted LPA 4-negative cells into a less motile phenotype. In support of the biological relevance of these observations, ectopic expression of LPA 4 strongly inhibited migration and invasion of human cancer cells. When coexpressed with LPA 1 in B103 neuroblastoma cells devoid of endogenous LPA receptors, LPA 4 attenuated LPA 1-driven migration and invasion, indicating functional antagonism between the two subtypes of LPA receptors. These results provide genetic and biochemical evidence that LPA 4 is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
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Tager, A. M., LaCamera, P., Shea, B. S., Campanella, G. S., Selman, M., Zhao, Z., Polosukhin, V., Wain, J., Karimi-Shah, B. A., Kim, N. D., et al. (2008) · Nature Medicine · doi:10.1038/nm1685 · Cited by 823
Cited by
LPA receptor signaling: pharmacology, physiology, and pathophysiology
Yung, Y. C., Stoddard, N. C., & Chun, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046458 · Cited by 710
Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Kihara, Y., Maceyka, M., Spiegel, S., & Chun, J. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12678 · Cited by 324
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Geraldo, L. H. M., Spohr, T. C. L. D. S., Amaral, R. F. D., Fonseca, A. C. C. D., Garcia, C., Mendes, F. D. A., Freitas, C., dosSantos, M. F., & Lima, F. R. S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00367-5 · Cited by 313
Lysophospholipids and their receptors in the central nervous system
Choi, J. W., & Chun, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.015 · Cited by 255
Desale, S. E., Chidambaram, H., & Chinnathambi, S. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00036-1 · Cited by 99
Metadata
- Authors
- Lee, Z., Cheng, C.-T., Zhang, H., Subler, M. A., Wu, J., Mukherjee, A., Windle, J. J., Chen, C.-K., & Fang, X.
- Venue
- Molecular Biology of the Cell
- Published
- 2008-12
- Volume
- 19
- Issue
- 12
- Pages
- 5435-5445
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2124900560
- Cited by
- 159
- References
- 1
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, Z., Cheng, C.-T., Zhang, H., Subler, M. A., Wu, J., Mukherjee, A., Windle, J. J., Chen, C.-K., & Fang, X. (2008). Role of LPA4/p2y9/GPR23 in Negative Regulation of Cell Motility. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e08-03-0316
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