G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease

Desale, Smita Eknath; Chidambaram, Hariharakrishnan; Chinnathambi, Subashchandrabose

doi:10.1186/s43556-021-00036-1

Cited by 99Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsReceptor Mechanisms and Signaling

G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease

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Desale, Smita Eknath, Chidambaram, Hariharakrishnan, Chinnathambi, Subashchandrabose·2021·Molecular Biomedicine

DOI 10.1186/s43556-021-00036-1PMC PMC8607389

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Abstract

Alzheimer’s disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of Tau protein that forms neurofibrillary tangles (NFTs) in neuronal cells. Along with these pathological proteins, the disease shows neuroinflammation, neuronal death, impairment in the immune function of microglia and synaptic loss, which are mediated by several important signaling pathways. The PI3K/Akt-mediated survival-signaling pathway is activated by many receptors such as G-protein coupled receptors (GPCRs), triggering receptor expressed on myeloid cells 2 (TREM2), and lysophosphatidic acid (LPA) receptor. The signaling pathway not only increases the survival of neurons but also regulates inflammation, phagocytosis, cellular protection, Tau phosphorylation and Aβ secretion as well. In this review, we focused on receptors, which activate PI3K/Akt pathway and its potential to treat Alzheimer’s disease. Among several membrane receptors, GPCRs are the major drug targets for therapy, and GPCR signaling pathways are altered during Alzheimer’s disease. Several GPCRs are involved in the pathogenic progression, phosphorylation of Tau protein by activation of various cellular kinases and are involved in the amyloidogenic pathway of amyloid-β synthesis. Apart from various GPCR signaling pathways, GPCR regulating/ interacting proteins are involved in the pathogenesis of Alzheimer’s disease. These include several small GTPases, Ras homolog enriched in brain, GPCR associated sorting proteins, β-arrestins, etc., that play a critical role in disease progression and has been elaborated in this review.

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One of the downstream pathways of TREM2-TYROBP is small GTPases in the Ras-homologous (Rho) family (e.g., Cdc42, Rac).
“One of the downstream pathways of TREM2-TYROBP is small GTPases in the Ras-homologous (Rho) family (e.g., Cdc42, Rac) (49, 50).”
From The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies (2023) · cites this paper as [49]

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[17]Das R, Balmik AA, Chinnathambi S. Melatonin reduces GSK3β expression and tau phosphorylation via Nrf2 nuclear translocation. BioRxiv. 2019:861229. 10.1101/861229. · DOI

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Authors: Desale, S. E., Chidambaram, H., & Chinnathambi, S.
Affiliations: National Chemical Laboratory (IN)
Corresponding author: Desale, Smita Eknath
Chidambaram, Hariharakrishnan
Chinnathambi, Subashchandrabose
ORCID: Chidambaram, Hariharakrishnan
Chinnathambi, Subashchandrabose
Venue: Molecular Biomedicine
Publisher: Springer Science and Business Media LLC
Published: 2021-06-10
Volume: 2
Issue: 1
Pages: 17-17
ISSN: 2662-8651 (ISSN-L)
DOI: 10.1186/s43556-021-00036-1
PMC: PMC8607389
OpenAlex: W3167086420
Cited by: 99
References: 223
Citations by year: 2026: 33 · 2025: 21 · 2024: 28 · 2023: 14 · 2022: 2 · 2021: 1
FWCI: 1.50
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Molecular Biomedicine (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Council of Scientific and Industrial Research, India (CSIR NCL/MLP 101726)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: Alzheimer's disease, G protein-coupled receptors, PI3K/Akt signaling, Rho GTPase signaling, tau phosphorylation, amyloid-beta, neurofibrillary tangles, TREM2, lysophosphatidic acid receptor, neuroinflammation, microglia, synaptic loss, beta-arrestin, small GTPases, therapeutic target

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G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease

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