The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
How Taxol/paclitaxel kills cancer cells
Open accessAbstract
Taxol (generic name paclitaxel) is a microtubule-stabilizing drug that is approved by the Food and Drug Administration for the treatment of ovarian, breast, and lung cancer, as well as Kaposi's sarcoma. It is used off-label to treat gastroesophageal, endometrial, cervical, prostate, and head and neck cancers, in addition to sarcoma, lymphoma, and leukemia. Paclitaxel has long been recognized to induce mitotic arrest, which leads to cell death in a subset of the arrested population. However, recent evidence demonstrates that intratumoral concentrations of paclitaxel are too low to cause mitotic arrest and result in multipolar divisions instead. It is hoped that this insight can now be used to develop a biomarker to identify the ∼50% of patients that will benefit from paclitaxel therapy. Here I discuss the history of paclitaxel and our recently evolved understanding of its mechanism of action.
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Cites
Promotion of microtubule assembly in vitro by taxol
SCHIFF, P. B., FANT, J., & HORWITZ, S. B. (1979) · Nature · doi:10.1038/277665a0 · Cited by 3,600
Gascoigne, K. E., & Taylor, S. S. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.002 · Cited by 832
Mitosis is not a key target of microtubule agents in patient tumors
Komlodi-Pasztor, E., Sackett, D., Wilkerson, J., & Fojo, T. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.228 · Cited by 314 · cited 3×
“It has been hypothesized that paclitaxel may interfere with cell signaling, trafficking, and microtubule-mediated transport (Herbst and Khuri, 2003; Komlodi-Pasztor et al., 2011).”
BackgroundKomlodi-Pasztor, E., Sackett, D. L., & Fojo, A. T. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0999 · Cited by 227
Walsh, V., & Goodman, J. (1999) · Social Science & Medicine · doi:10.1016/s0277-9536(99)00161-6 · Cited by 78
Cited by
Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00404-3 · Cited by 1,506
Seca, A., & Pinto, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010263 · Cited by 686
Plant-derived anticancer agents: A green anticancer approach
Iqbal, J., Abbasi, B. A., Mahmood, T., Kanwal, S., Ali, B., Shah, S. A., & Khalil, A. T. (2017) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2017.10.016 · Cited by 685
Progress in research on paclitaxel and tumor immunotherapy
Zhu, L., & Chen, L. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0164-y · Cited by 616
Natural Products as Anticancer Agents: Current Status and Future Perspectives
Naeem, A., Hu, P., Yang, M., Zhang, J., Liu, Y., Zhu, W., & Zheng, Q. (2022) · Molecules · doi:10.3390/molecules27238367 · Cited by 607
Metadata
- Authors
- Weaver, B. A.
- Venue
- Molecular Biology of the Cell
- Published
- 2014-09-15
- Volume
- 25
- Issue
- 18
- Pages
- 2677-2681
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2154747925
- Cited by
- 1,547
- References
- 5
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- green
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