The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy
Open accessAbstract
The nuclear lamina is a key structural element of the metazoan nucleus. However, the structural organization of the major proteins composing the lamina is poorly defined. Using three-dimensional structured illumination microscopy and computational image analysis, we characterized the supramolecular structures of lamin A, C, B1, and B2 in mouse embryo fibroblast nuclei. Each isoform forms a distinct fiber meshwork, with comparable physical characteristics with respect to mesh edge length, mesh face area and shape, and edge connectivity to form faces. Some differences were found in face areas among isoforms due to variation in the edge lengths and number of edges per face, suggesting that each meshwork has somewhat unique assembly characteristics. In fibroblasts null for the expression of either lamins A/C or lamin B1, the remaining lamin meshworks are altered compared with the lamin meshworks in wild-type nuclei or nuclei lacking lamin B2. Nuclei lacking LA/C exhibit slightly enlarged meshwork faces and some shape changes, whereas LB1-deficient nuclei exhibit primarily a substantial increase in face area. These studies demonstrate that individual lamin isoforms assemble into complex networks within the nuclear lamina and that A- and B-type lamins have distinct roles in maintaining the organization of the nuclear lamina.
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Cites
A Computational Approach to Edge Detection
Canny, J. (1986) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.1986.4767851 · Cited by 30,004
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
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Self-citationGenomic instability in laminopathy-based premature aging
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Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
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Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells
Kim, Y., Sharov, A. A., McDole, K., Cheng, M., Hao, H., Fan, C.-M., Gaiano, N., Ko, M. S. H., & Zheng, Y. (2011) · Science · doi:10.1126/science.1211222 · Cited by 247
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Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J. (2016) · Science · doi:10.1126/science.aad7297 · Cited by 1,318
Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression
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Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus
Stephens, A. D., Banigan, E. J., Adam, S. A., Goldman, R. D., & Marko, J. F. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-09-0653 · Cited by 473
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Metadata
- Authors
- Shimi, T., Kittisopikul, M., Tran, J., Goldman, A. E., Adam, S. A., Zheng, Y., Jaqaman, K., & Goldman, R. D.
- Venue
- Molecular Biology of the Cell
- Published
- 2015-11-05
- Volume
- 26
- Issue
- 22
- Pages
- 4075-4086
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2287005707
- Cited by
- 252
- References
- 5
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Shimi, T., Kittisopikul, M., Tran, J., Goldman, A. E., Adam, S. A., Zheng, Y., Jaqaman, K., & Goldman, R. D. (2015). Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e15-07-0461
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