An Avatar-Led Intervention Promotes Smoking Cessation in Young Adults: A Pilot Randomized Clinical Trial
Open accessAbstract
Background: Smoking remains a global concern, especially for young adults. There is a dearth of smoking cessation programs for this population, who seldom seek help or are motivated to quit. Purpose: This pilot study assessed the effectiveness of a digital avatar-led Acceptance and Commitment Therapy (ACT) smoking cessation program (Flexiquit) for young adult smokers at all levels of motivation to quit. Methods: Smokers with no particular interest in quitting smoking (65.45% reported being in pre-contemplation or contemplation stages of change) were recruited from three universities (105 smoking ≥ 1 cigarette per day during the past 30 days, 68 females). Those who completed questionnaires online (N = 84; M = 22.44 years, SD = 2.61, range 18–28 years old) were randomized to either a six-session avatar-led intervention (Flexiquit; N = 49) or a wait-list control (N = 35). Primary outcomes included cessation status (7-day point prevalence) and number of cigarettes smoked per day; secondary outcomes were nicotine dependence, intention-to-quit smoking and self-efficacy, assessed at pre- and post-intervention, and only for Flexiquit at 6-month follow-up. Results: In intention-to-treat analysis more participants (OR = 3.10, 95% CI = 0.92–10.41) in the treatment group (28.57%) versus the control group (11.43%) reported quitting smoking; however, the difference was not statistically significant (p = .067). There were statistically significant decreases in average number of cigarettes, nicotine dependence and increases in self-efficacy, and intention-to-quit smoking compared to controls. Treatment gains in the Flexiquit group were maintained through the 6-month follow-up. Conclusions: An avatar-led digitized smoking cessation intervention based on ACT could increase the odds of quitting smoking. Findings suggest that a digitized program designed to engage young adults in smoking cessation may result in quitting smoking and has a high applicability potential especially among the hard-to-reach population of young adults. Question: Can an avatar-led digitized Acceptance and Commitment Therapy (ACT) smoking cessation intervention result in quitting smoking and increasing intention to quit among young smokers at various levels of motivation to quit, compared to a wait-list control group? Findings: In this pilot randomized clinical trial that included 84 smokers, 28.57% in the treatment condition versus 11.43% in the wait-list control group were abstinent at post (intention-to-treat [ITT] analysis). An avatar-led digitized ACT smoking cessation intervention results in high quitting smoking rates and has a high applicability potential especially among the hard-to-reach population of young adult smokers.
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Smartphone apps can be discreetly accessed, potentially reducing stigma often experienced by individuals with mental health disorders.
“Moreover, smartphone apps can be discreetly accessed, potentially reducing stigma often experienced by individuals with mental health disorders [42].”
From Can an Acceptance and Commitment Therapy-Based Smartphone App Help Individuals with Mental Health Disorders Quit Smoking? (2024) · cites this paper as [42]
Cites
The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738 · see citing works
Evaluating the public health impact of health promotion interventions: the RE-AIM framework.
Glasgow, R. E., Vogt, T. M., & Boles, S. M. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.9.1322 · Cited by 7,217 · see citing works
From Game Design Elements to Gamefulness: Defining “Gamification”
Deterding, S., Dixon, D., Khaled, R., & Nacke, L. E. (2011) · IT University Of Copenhagen (IT University of Copenhagen) · Cited by 1,341 · see citing works
The Contemplation Ladder: validation of a measure of readiness to consider smoking cessation.
Biener, L., & Abrams, D. (1991) · Health Psychology · doi:10.1037/0278-6133.10.5.360 · Cited by 1,094 · see citing works
(2002) · Cited by 770 · see citing works
Assessment of patient satisfaction: Development and refinement of a Service Evaluation Questionnaire
Nguyen, T. D., Attkisson, C. C., & Stegner, B. L. (1983) · Evaluation and Program Planning · doi:10.1016/0149-7189(83)90010-1 · Cited by 736 · see citing works
Gamification: What It Is and Why It Matters to Digital Health Behavior Change Developers
Cugelman, B. (2013) · JMIR Serious Games · doi:10.2196/games.3139 · Cited by 531 · see citing works
Acceptance-based treatment for smoking cessation
Gifford, E. V., Kohlenberg, B. S., Hayes, S. C., Antonuccio, D. O., Piasecki, M. M., Rasmussen-Hall, M. L., & Palm, K. M. (2004) · Behavior Therapy · doi:10.1016/s0005-7894(04)80015-7 · Cited by 499 · see citing works
Electronic Cigarettes and Conventional Cigarette Use Among US Adolescents: A Cross-sectional Study
Dutra, L. M., & Glantz, S. A. (2014) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2013.5488 · Cited by 496 · see citing works
Ebert, D. D., Van Daele, T., Nordgreen, T., Karekla, M., Compare, A., Zarbo, C., Brugnera, A., Øverland, S., Trebbi, G., Jensen, K. L., et al. (2018) · European Psychologist · doi:10.1027/1016-9040/a000318 · Cited by 437 · see citing works
Self-citationMotivational interviewing for smoking cessation
Lai, D. T., Cahill, K., Qin, Y., & Tang, J.-L. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006936.pub2 · Cited by 417 · see citing works
Mortality from cancer in relation to smoking: 50 years observations on British doctors
Doll, R., Peto, R., Boreham, J., & Sutherland, I. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602359 · Cited by 392 · see citing works
Tobacco cessation interventions for young people
Grimshaw, G. M., & Stanton, A. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003289.pub4 · Cited by 359 · see citing works
Are adolescent smokers dependent on nicotine? A review of the evidence
Colby, S. M., Tiffany, S. T., Shiffman, S., & Niaura, R. S. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00166-0 · Cited by 312 · see citing works
Measuring nicotine dependence among high-risk adolescent smokers
Prokhorov, A. V., Pallonen, U. E., Fava, J. L., Ding, L., & NIAURA, R. S. (1996) · Addictive Behaviors · doi:10.1016/0306-4603(96)00048-2 · Cited by 308 · see citing works
Macea, D. D., Gajos, K., Daglia Calil, Y. A., & Fregni, F. (2010) · The Journal of Pain · doi:10.1016/j.jpain.2010.06.005 · Cited by 289 · see citing works
Development and validation of a scale measuring self‐efficacy of current and former smokers
Etter, J., Bergman, M. M., Humair, J., & Perneger, T. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.9569017.x · Cited by 260 · see citing works
Use of Tobacco Cessation Treatments Among Young Adult Smokers: 2005 National Health Interview Survey
Curry, S. J., Sporer, A. K., Pugach, O., Campbell, R. T., & Emery, S. (2007) · American Journal of Public Health · doi:10.2105/ajph.2006.103788 · Cited by 158 · see citing works
Reduced smoking: an introduction and review of the evidence
Hughes, J. R. (2000) · Addiction · doi:10.1080/09652140032008 · Cited by 142 · see citing works
Hutton, H. E., Wilson, L. M., Apelberg, B. J., Avila Tang, E., Odelola, O., Bass, E. B., & Chander, G. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq252 · Cited by 132 · see citing works
Smoking-Cessation Interventions for U.S. Young Adults
Villanti, A. C., McKay, H., Abrams, D. B., Holtgräve, D. R., & Bowie, J. V. (2010) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2010.08.009 · Cited by 124 · see citing works
Creating a strategy for progress: A contextual behavioral science approach
Vilardaga, R., Hayes, S. C., Levin, M. E., & Muto, T. (2009) · The Behavior Analyst · doi:10.1007/bf03392178 · Cited by 118 · see citing works
Karekla, M., Kasinopoulos, O., Neto, D. D., Ebert, D. D., Van Daele, T., Nordgreen, T., Höfer, S., Oeverland, S., & Jensen, K. L. (2019) · European Psychologist · doi:10.1027/1016-9040/a000349 · Cited by 117 · see citing works
Self-citationTobacco cessation interventions for young people
Stanton, A., & Grimshaw, G. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003289.pub5 · Cited by 113 · see citing works
Hughes, J. R., Carpenter, M. J., & Naud, S. J. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq078 · Cited by 107 · see citing works
Ramo, D. E., Young‐Wolff, K. C., & Prochaska, J. J. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.10.019 · Cited by 103 · see citing works
Bricker, J. B., Bush, T., Zbikowski, S. M., Mercer, L. D., & Heffner, J. L. (2014) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntu102 · Cited by 100 · see citing works
Youth tobacco use cessation: 2008 update
Sussman, S. Y., & Sun, P. (2009) · Tobacco Induced Diseases · doi:10.1186/1617-9625-5-3 · Cited by 85 · see citing works
Smoking cessation: Principles and practice based upon the AHCPR Guideline, 1996
Fiore, M. C., Jorenby, D. E., & Baker, T. B. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02892286 · Cited by 78 · see citing works
Telephone counseling increases cessation rates among young adult smokers.
Rabius, V. A., McAlister, A. L., Geiger, A., Huang, P. P., & Todd, R. (2004) · Health Psychology · doi:10.1037/0278-6133.23.5.539 · Cited by 77 · see citing works
State-of-the-Art Office-Based Interventions to Eliminate Youth Tobacco Use: The Past Decade
Pbert, L. A., Farber, H. J., Horn, K. A., Lando, H. A., Muramoto, M. L., O’Loughlin, J. L., Tanski, S. E., Wellman, R. J., Winickoff, J. P., & Klein, J. D. (2015) · PEDIATRICS · doi:10.1542/peds.2014-2037 · Cited by 75 · see citing works
Polytobacco, marijuana, and alcohol use patterns in college students: A latent class analysis
Haardörfer, R., Berg, C. J., Lewis, M. V., Payne, J. B., Pillai, D., McDonald, B., & Windle, M. T. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.03.034 · Cited by 71 · see citing works
A Randomized Trial of an Avatar-Hosted Multiple Behavior Change Intervention for Young Adult Smokers
An, L. C., Demers, M., Kirch, M., Considine-Dunn, S. E., Nair, V. N., Dasgupta, K., Narisetty, N. N., Resnicow, K., & Ahluwalia, J. S. (2013) · JNCI Monographs · doi:10.1093/jncimonographs/lgt021 · Cited by 65 · see citing works
Simmons, V. N., Heckman, B. W., Fink, A. C., Small, B. J., & Brandon, T. H. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0032952 · Cited by 59 · see citing works
Smoking prevalence and tobacco exposure among adolescents in Cyprus
Karekla, M., Symeou, A., Tsangari, H., Kapsou, M., & Constantinou, M. (2009) · European Journal of Public Health · doi:10.1093/eurpub/ckp064 · Cited by 19 · see citing works
Self-citationHooper, N., Dack, C., Karekla, M., Niyazi, A., & McHugh, L. (2018) · Addiction Research & Theory · doi:10.1080/16066359.2018.1434156 · Cited by 12 · see citing works
Self-citationKarekla, M., Kapsou, M., Ioannou, V. A., Gregoriou, I., Christodoulou, A., & Gkliaou, M. A. (2010) · Psychology and Health · Cited by 6 · see citing works
Self-citationPromoting Adolescent Smoking Cessation Is Worth the Effort
McFee, R. B., Boykan, R., Lasner, H., & Mazure, B. (2001) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.155.3.419 · Cited by 4 · see citing works
Flagged first, then by citations
4 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Impact of COVID-19 pandemic on mental health: An international study
Gloster, A. T., Lamnisos, D., Lubenko, J., Presti, G., Squatrito, V., Constantinou, M., Nicolaou, C., Papacostas, S., Aydın, G., Chong, Y. Y., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0244809 · Cited by 558 · see citing works
Self-citationBendotti, H., Lawler, S., Chan, G., GARTNER, C. E., Ireland, D., & Marshall, H. (2023) · Digital Health · doi:10.1177/20552076231211634 · Cited by 56 · see citing works
Chatbots for Smoking Cessation: Scoping Review
Whittaker, R., Dobson, R., & Garner, K. (2022) · Journal of Medical Internet Research · doi:10.2196/35556 · Cited by 41 · see citing works
Mindfulness for smoking cessation
Jackson, S., Brown, J., Norris, E., Livingstone-Banks, J., Hayes, E., & Lindson, N. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013696.pub2 · Cited by 45 · see citing works
Tatnell, P., Atorkey, P., & Tzelepis, F. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710821 · Cited by 31 · see citing works
Mönninghoff, A., Fuchs, K., Wu, J., Albert, J. L., & Mayer, S. (2022) · Journal of Medical Internet Research · doi:10.2196/32487 · Cited by 30 · see citing works
Theofanous, A., Ioannou, M., Zacharia, M., Γεωργίου, Σ. Ν., & Karekla, M. (2020) · Mindfulness · doi:10.1007/s12671-020-01350-5 · Cited by 29 · see citing works
Self-citationKarekla, M., Nikolaou, P., & Merwin, R. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11071775 · Cited by 27 · see citing works
Self-citationHeffner, J. L., Watson, N. L., Serfozo, E., Kelly, M. M., Reilly, E. D., Kim, D., Baker, K. K., Scout, N., & Karekla, M. (2021) · JMIR Formative Research · doi:10.2196/30241 · Cited by 28 · see citing works
Self-citationZacharia, M., Ioannou, M., Theofanous, A., Vasiliou, V. S., & Karekla, M. (2021) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2021.01.003 · Cited by 11 · see citing works
Self-citationBricker, J. B., Sullivan, B. M., Mull, K. E., Torres, A. J., & Carpenter, K. (2022) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntac052 · Cited by 13 · see citing works
Nicolaou, P., Merwin, R. M., & Karekla, M. (2022) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2022.06.001 · Cited by 11 · see citing works
Self-citationEfficacy of digital therapeutics in smoking cessation: A systematic review and meta-analysis
Liu, L., Zhao, Y., Li, J., Zhang, N., Lan, Z., & Liu, X. (2023) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2023.100209 · Cited by 11 · see citing works
Heffner, J. L., Kelly, M. M., Reilly, E. D., Reece, S. G., Claudio, T., Serfozo, E., Baker, K. K., Watson, N. L., & Karekla, M. (2023) · JMIR Formative Research · doi:10.2196/44503 · Cited by 11 · see citing works
Self-citationDevelopment of a Virtual Human for Supporting Tobacco Cessation During the COVID-19 Pandemic
Loveys, K., Lloyd, E., Sagar, M. A., & Broadbent, E. (2023) · Journal of Medical Internet Research · doi:10.2196/42310 · Cited by 11 · see citing works
Kwan, Y. K., Lau, Y., Ang, W. W., & Lau, S. T. (2024) · Nicotine and Tobacco Research · doi:10.1093/ntr/ntad145 · Cited by 9 · see citing works
ChatGPT-Based Chatbot for Help Quitting Smoking via Text Messaging: An Interventional Study
Abroms, L. C., Wysota, C. N., Yousefi, A., Wu, T.-C., & Broniatowski, D. A. (2025) · JMIR Formative Research · doi:10.2196/79402 · Cited by 5 · see citing works
Hammond, C. J., Webb, L., Lee, C. Y., Adegbindin, A., Park, G. S. H., Lebo, R. A., Nanavati, J., & Sibinga, E. M. S. (2026) · PEDIATRICS · doi:10.1542/peds.2025-070779 · Cited by 5 · see citing works
Heffner, J. L., Baker, K., Georgiou, K., Graham, A. L., Kelly, M. M., Konstantinou, P., Lamprou, E., Lele, C., Lok, K. Z., Orzechowski, M., et al. (2025) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaf112 · Cited by 5 · see citing works
Self-citationMilkowski, M., Olesk, J., Asfura, D. M., Barco, C., Cervera, C., Wachira, M., Sisk, M. L., Balke, A. E., Purushotham, D., Williams, R., et al. (2024) · International ACM SIGGROUP Conference on Supporting Group Work (GROUP) · doi:10.1145/3688828.3699642 · Cited by 4 · see citing works
Bendotti, H., Lawler, S., Ireland, D., GARTNER, C. E., & Marshall, H. (2024) · JMIR Human Factors · doi:10.2196/56505 · Cited by 4 · see citing works
Albers, N., Neerincx, M. A., & Brinkman, W. (2025) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-025-03164-8 · Cited by 3 · see citing works
Chhabra, D., Sachan, T., Penberthy, J. K., & Dang, S. (2023) · Current Psychology · doi:10.1007/s12144-023-04967-6 · Cited by 3 · see citing works
Santiago-Torres, M., Mull, K. E., Sullivan, B. M., Prochaska, J. J., Zvolensky, M. J., & Bricker, J. B. (2024) · Depression and Anxiety · doi:10.1155/2024/1055801 · Cited by 3 · see citing works
“Moreover, smartphone apps can be discreetly accessed, potentially reducing stigma often experienced by individuals with mental health disorders [42].”
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Peckham, E. J., Machaczek, K. K., Mishu, M. P., Gibril, N., & Spanakis, P. (2025) · Substance Use & Misuse · doi:10.1080/10826084.2025.2530785 · Cited by 2 · see citing works
Fan, J., Lei, X.-X., Zhang, J., Chang, Y., Jiang, N., Qu, Z., Liang, B., & Qu, D. (2025) · Worldviews on Evidence-Based Nursing · doi:10.1111/wvn.70086 · Cited by 1 · see citing works
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Bricker, J. B. (2021) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197550076.013.23 · Cited by 1 · see citing works
Multidisciplinary Investigation on How Avatars and Devices Affect Human Physiology
Kawaoka, S., Izumi, Y., Nakata, K., Haruno, M., Tanaka, T., Sumioka, H., Achanccaray, D., & Nakae, A. (2024) · Springer eBooks · doi:10.1007/978-981-97-3752-9_7 · Cited by 1 · see citing works
Chatbots for Smoking Cessation: Scoping Review (Preprint)Preprint
Whittaker, R., Dobson, R., & Garner, K. (2021) · doi:10.2196/preprints.35556 · Cited by 1 · see citing works
Acceptance and Commitment Therapy (ACT) for Smoking Cessation: A Scoping Review
Liu, J., Pei, Y., Ma, H., Liu, X., Zhang, X., Xia, W., & Yang, Q. (2026) · Nursing Research · doi:10.1097/nnr.0000000000000900
Richiardi, L., Pizzi, C., Paolotti, D., & Blumenberg, C. (2023) · Springer eBooks · doi:10.1007/978-1-4614-6625-3_59-1
Effectiveness of Self-Help Smoking Cessation Programs in the 21st Century: A Systematic Review
Fillette, L., & Varescon, I. (2025) · Journal of Addictions Nursing · doi:10.1097/jan.0000000000000629
Fillette, L., & Varescon, I. (2025) · Tobacco Prevention & Cessation · doi:10.18332/tpc/208808
Coronado‐Montoya, S., Varadi, A.-L., Dozet, D., Chiodo, D., & Henderson, J. L. (2026) · doi:10.2196/preprints.99389
van Vliet, M. H. M., Versluis, A., Penfornis, K. M., Baccinelli, W., Scheltinga, B. L., Albers, N., Chavannes, N. H., Rippe, R. C. A., & Meijer, E. (2026) · Digital Health · doi:10.1177/20552076261450745
Coronado‐Montoya, S., Varadi, A.-L., Dozet, D., Chiodo, D., & Henderson, J. L. (2026) · Journal of Medical Internet Research · doi:10.2196/99389
- Authors
- Karekla, M., Savvides, S. N., & Gloster, A.
- Affiliations
- University of Cyprus (CY)
- University of Basel (CH)
- Corresponding author
- Karekla, Maria
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-05-08
- Volume
- 54
- Issue
- 10
- Pages
- 747-760
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- OpenAlex
- W3021875383
- Cited by
- 36
- References
- 43
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
- edoc.unibas.ch
- Licence
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion, other-oa)
- edoc (University of Basel)
- Funders
- University of Cyprus
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Keywords
- smoking cessation, young adults, acceptance and commitment therapy, digital health interventions, nicotine dependence, turnover intention, self-efficacy, precontemplation, contemplation, university students, hard-to-reach populations, tobacco use reduction
- MeSH terms
- Internet-Based Intervention, Cyprus, Female, Humans, Male, Motivation, Pilot Projects, Students, Tobacco Use Disorder, Universities, Smoking Cessation, Self Efficacy, Intention, Young Adult, Acceptance and Commitment Therapy
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