Protective role of epigallocatechin-3-gallate in health and disease: A perspective
Abstract
Tea is the most popular beverages all over the world. Polyphenols are found ubiquitously in tea leaves and their regular consumption has been associated with a reduced risk of a number of chronic diseases including cancer, cardiovascular and neurodegenerative diseases. Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in tea leaves and received great attention due to their protective role in the prevention of the diseases. Rather than eliciting direct antioxidant effects, the mechanisms by which tea polyphenol express these beneficial properties appear to involve their interaction with cellular signaling pathways and related machinery that mediate cell function under both normal and pathological conditions. The central focus of this review is to provide an overview of the role that the major tea polyphenol, EGCG plays in preventing cancer, cardiovascular and neurodegenerative diseases. This review present epidemiological data, human intervention study findings, as well as animal and in vitro studies in support of these actions and delineates the molecular mechanism associated with the action of EGCG in ameliorating of such diseases.
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Epigallocatechin-3-gallate has been confirmed to prevent diabetes, cancer, cardiac disease, lung disease, and neurodegenerative disease.
“Epigallocatechin-3-gallate has been confirmed to prevent diabetes, cancer, cardiac disease, lung disease, and neuro degenerative disease [27].”
From Potential Valorization of Banana Production Waste in Developing Countries: Bio-Engineering Aspects (2024) · cites this paper as [27]
Banana peel sorbents may be useful in Bangladesh, China, Mexico, Egypt, Cambodia, and India, where heavy metal water pollution makes drinking or cooking with the water unsafe.
“This may be useful in Bangladesh, China, Mexico, Egypt, Cambodia, and India, where heavy metal water pollution makes drinking or cooking with the water unsafe [27].”
From Potential Valorization of Banana Production Waste in Developing Countries: Bio-Engineering Aspects (2024) · cites this paper as [27]
Cites
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works
Green tea composition, consumption, and polyphenol chemistry
Graham, H. N. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90041-f · Cited by 1,889 · see citing works
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854 · cited 1× · see citing works
“EGCG is renowned as the major catechin of green tea for its maximum health bene fi cial effect [19].”
Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
Yang, C. S., Wang, X., Lü, G., & Picinich, S. C. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2641 · Cited by 1,153 · see citing works
Beneficial effects of green tea: A literature review
Sabu, M. C., Thambi, P. T., Kuttan, R., & Nishigaki, I. (2010) · Chinese Medicine · doi:10.1186/1749-8546-5-13 · Cited by 992 · see citing works
Tea polyphenols: prevention of cancer and optimizing health
Mukhtar, H., & Ahmad, N. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1698s · Cited by 904 · see citing works
Bettuzzi, S., Brausi, M. A., Rizzi, F., Castagnetti, G., Peracchia, G., & Corti, A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1145 · Cited by 817 · see citing works
The Role of Tea in Human Health: An Update
McKay, D. L., & Blumberg, J. B. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719187 · Cited by 772 · see citing works
Rezai-Zadeh, K., Shytle, D., Sun, N., Mori, T., Hou, H., Jeanniton, D., Ehrhart, J., Townsend, K., Zeng, J., Morgan, D., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1521-05.2005 · Cited by 713 · see citing works
A Review of the Health Effects of Green Tea Catechins in In Vivo Animal Models
Crespy, V., & Williamson, G. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3431s · Cited by 599 · see citing works
Total Phenol, Catechin, and Caffeine Contents of Teas Commonly Consumed in the United Kingdom
Khokhar, S., & Magnusdottir, S. G. M. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010153l · Cited by 533 · see citing works
Antimutagenic and anticarcinogenic activity of tea polyphenols
Kuroda, Y., & Hara, Y. (1999) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(98)00019-2 · Cited by 522 · see citing works
Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
Weinreb, O., Mandel, S. A., Amit, T., & Youdim, M. B. H. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.05.002 · Cited by 506 · see citing works
Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols
Gupta, S., Hastak, K., Ahmad, N., Lewin, J. S., & Mukhtar, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171326098 · Cited by 488 · see citing works
Epigallocatechin Gallate, a Constituent of Green Tea, Represses Hepatic Glucose Production
Waltner-Law, M. E., Wang, X. L., Law, B. K., Hall, R. K., Nawano, M., & Granner, D. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204672200 · Cited by 485 · see citing works
Degradation of Green Tea Catechins in Tea Drinks
Chen, Z., Zhu, Q. Y., Tsang, D., & Huang, Y. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000877h · Cited by 473 · see citing works
Rezai-Zadeh, K., Arendash, G. W., Hou, H., Fernandez, F., Jensen, M., Runfeldt, M., Shytle, R. D., & Tan, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.107 · Cited by 459 · see citing works
Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project
Kuriyama, S., Hozawa, A., Ohmori, K., Shimazu, T., Matsui, T., Ebihara, S., Awata, S., Nagatomi, R., Arai, H., & Tsuji, I. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.355 · Cited by 428 · see citing works
Klaus, S., Pültz, S., Thöne‐Reineke, C., & Wolfram, S. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802926 · Cited by 423 · see citing works
Nakachi, K., Matsuyama, S., Miyaké, S., Suganuma, M., & Imai, K. (2000) · BioFactors · doi:10.1002/biof.5520130109 · Cited by 405 · see citing works
Effect of EGCG on lipid absorption and plasma lipid levels in rats
Raederstorff, D., Schlachter, M., Elste, V., & Weber, P. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00054-8 · Cited by 396 · see citing works
Kobayashi, Y., Suzuki, M. M., Satsu, H., Arai, S., Hara, Y., Suzuki, K., Miyamoto, Y., & Shimizu, M. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0006832 · Cited by 386 · see citing works
Ritchie, K. A., & Lovestone, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11667-9 · Cited by 386 · see citing works
Mandel, S. A., Weinreb, O., Amit, T., & Youdim, M. B. H. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02291.x · Cited by 379 · see citing works
Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health
Wolfram, S. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719626 · Cited by 370 · see citing works
Checkoway, H., Powers, K. M., Smith‐Weller, T., Franklin, G. M., Longstreth, W. T., & Swanson, P. D. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.8.732 · Cited by 370 · see citing works
Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea
Haqqi, T. M., Anthony, D. D., Gupta, S., Ahmad, N., Lee, M.-S., Kumar, G. K., & Mukhtar, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4524 · Cited by 366 · see citing works
Multitargeted therapy of cancer by green tea polyphenols
Khan, N., & Mukhtar, H. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.014 · Cited by 365 · see citing works
Does Tea Affect Cardiovascular Disease? A Meta-Analysis
Peters, U. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.6.495 · Cited by 362 · see citing works
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
Herman, M. A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29027 · Cited by 349 · see citing works
Donà, M., Dell’Aica, I., Calabrese, F., Benelli, R., Morini, M., Albini, A., & Garbisa, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4335 · Cited by 334 · see citing works
Epigallocatechin Gallate Supplementation Alleviates Diabetes in Rodents
Wolfram, S., Raederstorff, D., Preller, M., Wang, Y., Teixeira, S. R., Riegger, C., & Weber, P. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2512 · Cited by 332 · see citing works
Kao, Y., Chang, H.-H., Lee, M., & Chen, C. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500109 · Cited by 318 · see citing works
Lambert, J. D., Lee, M., Lu, H., Meng, X., Hong, J. J. J., Seril, D. N., Yang, C. S., & Sturgill, M. G. (2003) · Journal of Nutrition · doi:10.1093/jn/133.12.4172 · Cited by 318 · see citing works
Tsuneki, H., Ishizuka, M., Terasawa, M., Wu, J.-B., Sasaoka, T., & Kimura, I. (2004) · BMC Pharmacology · doi:10.1186/1471-2210-4-18 · Cited by 311 · see citing works
A Single Ascending Dose Study of Epigallocatechin Gallate in Healthy Volunteers
Ullmann, U., Haller, J., Decourt, J., Girault, N., Girault, J., Richard-Caudron, A., Pineau, B., & Weber, P. (2003) · Journal of International Medical Research · doi:10.1177/147323000303100205 · Cited by 299 · see citing works
Adhami, V. M., Siddiqui, I. A., Ahmad, N., Gupta, S., & Mukhtar, H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2840 · Cited by 296 · see citing works
Paschka, A. G., Butler, R., & Young, C. Y. F. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00084-6 · Cited by 290 · see citing works
Green Tea Consumption and Prostate Cancer Risk in Japanese Men: A Prospective Study
Kurahashi, N., Sasazuki, S., Iwasaki, M., Inoue, M., & Shoichiro Tsugane for the JPHC Study Group (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm249 · Cited by 282 · see citing works
Coffee and tea consumption and the risk of Parkinson's disease
Hu, G., Bidel, S., Jousilahti, P., Antikaínen, R., & Tuomilehto, J. O. (2007) · Movement Disorders · doi:10.1002/mds.21706 · Cited by 281 · see citing works
Tea flavonoids and cardiovascular diseases: A review
Tijburg, L. B. M., Mattern, T., Folts, J. D., Weisgerber, U. M., & Katan, M. (1997) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399709527802 · Cited by 274 · see citing works
EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer
Shankar, S. (2007) · Frontiers in bioscience · doi:10.2741/2691 · Cited by 273 · see citing works
Lee, J. W., Lee, Y. K., Ban, J. O., Ha, T. Y., Yun, Y. P., Han, S., Oh, K. W., & Hong, J. T. (2009) · Journal of Nutrition · doi:10.3945/jn.109.109785 · Cited by 269 · see citing works
Roccaro, A. S., Blanco, A. R., Giuliano, F., Rusciano, D., & Enea, V. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.1968-1973.2004 · Cited by 265 · see citing works
Cancer prevention by tea: Evidence from laboratory studies
Yang, C. S., Wang, H., Li, G. X., Yang, Z., Guan, F., & Jin, H. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.03.001 · Cited by 259 · see citing works
Green Tea Inhibits Vascular Endothelial Growth Factor (VEGF) Induction in Human Breast Cancer Cells
Sartippour, M. R., Shao, Z., Beatty, P. H., et al. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2307 · Cited by 247 · see citing works
Inhibition of adenovirus infection and adenain by green tea catechins
WEBER, J. M., Ruzindana-Umunyana, A., Imbeault, L., & Sircar, S. (2003) · Antiviral Research · doi:10.1016/s0166-3542(02)00212-7 · Cited by 225 · see citing works
Chyu, K., Babbidge, S. M., Zhao, X., Dandillaya, R., Rietveld, A. G., Yano, J., Dimayuga, P. C., Cercek, B., & Shah, P. K. (2004) · Circulation · doi:10.1161/01.cir.0000128034.70732.c2 · Cited by 223 · see citing works
Siddiqui, I. A., Malik, A., Adhami, V. M., Asim, M., Hafeez, B. B., Sarfaraz, S., & Mukhtar, H. (2007) · Oncogene · doi:10.1038/sj.onc.1210840 · Cited by 223 · see citing works
Kavanagh, K. T., Hafer, L. J., Kim, D. W., Mann, K. K., Sherr, D. H., Rogers, A. E., & Sonenshein, G. E. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1164 · Cited by 223 · see citing works
Ju, J., Hong, J., Zhou, J.-N., Pan, Z., Bose, M., Liao, J., Yang, G., Liu, Y. Y., Hou, Z., Lin, Y., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1949 · Cited by 219 · see citing works
Acute EGCG Supplementation Reverses Endothelial Dysfunction in Patients with Coronary Artery Disease
Widlansky, M. E., Hamburg, N. M., Anter, E., HOLBROOK, M. M., Kahn, D. F., Elliott, J. G., Keaney, J. F., & Vita, J. A. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719590 · Cited by 217 · see citing works
Obregon, D. F., Rezai-Zadeh, K. P., Bai, Y., Sun, N., Hou, H., Ehrhart, J. C., Zeng, J., Mori, T., Arendash, G. W., Shytle, D., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600617200 · Cited by 210 · see citing works
Brusselmans, K., Schrijver, E. D., Heyns, W., Verhoeven, G., & Swinnen, J. V. (2003) · International Journal of Cancer · doi:10.1002/ijc.11317 · Cited by 205 · see citing works
Recent advances on tea polyphenols
Dou, Q. P. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e363 · Cited by 204 · see citing works
Wu, L.-Y., Juan, C., Hwang, L. S., Hsu, Y.-P., Ho, P., & Ho, L. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0450-x · Cited by 202 · see citing works
How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicity in Vitro
Lorenzen, N., Nielsen, S. B., Yoshimura, Y., Vad, B. S., Andersen, C. B., Betzer, C., Kaspersen, J. D., Christiansen, G., Pedersen, J. S., Jensen, P. H., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554667 · Cited by 202 · see citing works
Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay
Langley‐Evans, S. C. (2000) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480050029683 · Cited by 194 · see citing works
Moyers, S. B., & Kumar, N. B. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00041.x · Cited by 193 · see citing works
A New Function of Green Tea: Prevention of Lifestyle‐related Diseases
Sueoka, N., Suganuma, M., Sueoka, E., Okabe, S., Matsuyama, S., Imai, K., Nakachi, K., & Fujiki, H. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05656.x · Cited by 193 · see citing works
Tea polyphenols, their biological effects and potential molecular targets.
Chen, D., Milacic, V., Chen, M. S., Wan, S. B., Lam, W. H., Huo, C., Landis‐Piwowar, K. R., Cui, Q. C., Wali, A., Chan, T. H., et al. (2008) · PubMed · doi:10.14670/hh-23.487 · Cited by 186 · see citing works
Fernández, P. L., Martín, M. J., González, A. G., & Pablos, F. (2000) · The Analyst · doi:10.1039/a909219f · Cited by 185 · see citing works
CHUNG, S. S., & Vadgama, J. V. (2015) · PubMed · Cited by 184 · see citing works
Epigallocatechin, a Green Tea Polyphenol, Attenuates Myocardial Ischemia Reperfusion Injury in Rats
Aneja, R. K., Hake, P. W., Burroughs, T. J., Denenberg, A. G., Wong, H. R., & Zingarelli, B. (2004) · Molecular Medicine · doi:10.2119/2004-00032.aneja · Cited by 182 · see citing works
Stabilizing Effect of Ascorbic Acid on Green Tea Catechins
Chen, Z., Zhu, Q. Y., Wong, Y. F., et al. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf971022g · Cited by 182 · see citing works
Lee, Y. K., Yuk, D. Y., Lee, J. W., Lee, S. Y., Ha, T. Y., Oh, K. W., Yun, Y. P., & Hong, J. T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.012 · Cited by 181 · see citing works
Recent advances on tea polyphenols
Kanwar, J. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/363 · Cited by 177 · see citing works
Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies
Sun, C., Yuan, J., Koh, W., & Yu, M. C. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl024 · Cited by 177 · see citing works
Inoue, M., Tajima, K., Mizutani, M., Iwata, H., Iwase, T., Miura, S., Hirose, K., Hamajima, N., & Tominaga, S. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00486-4 · Cited by 173 · see citing works
Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise
Syed, D. N., Khan, N., Afaq, F., & Mukhtar, H. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0942 · Cited by 173 · see citing works
Tea flavonoids and cardiovascular health
Riemersma, R. A. (2001) · QJM · doi:10.1093/qjmed/94.5.277 · Cited by 169 · see citing works
Ortsäter, H., Grankvist, N., Wolfram, S., Kuehn, N., & Sjöholm, Å. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-11 · Cited by 163 · see citing works
Sano, M., Tabata, M., Suzuki, M., Degawa, M., Miyase, T., & Maeda‐Yamamoto, M. (2001) · The Analyst · doi:10.1039/b102541b · Cited by 163 · see citing works
Yamabe, N., Yokozawa, T., Oya, T., & Kim, M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107029 · Cited by 162 · see citing works
Yamamoto, T., Hsu, S., Lewis, J. B., Wataha, J. C., Dickinson, D. P., Singh, B. B., Bollag, W. B., Lockwood, P. E., Ueta, E., Osaki, T., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054676 · Cited by 157 · see citing works
Tijburg, L. B. M., Wiseman, S. A., Meijer, G. W., & Weststrate, J. A. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00139-1 · Cited by 155 · see citing works
Anticarcinogenic Activity of Green Tea Polyphenols
Komori, A., Yatsunami, J., Okabe, S., et al. (1993) · Japanese Journal of Clinical Oncology · doi:10.1093/oxfordjournals.jjco.a039631 · Cited by 153 · see citing works
Choi, J., Park, C., Kim, D.-J., Cho, M., Jin, B.-K., Pie, J.-E., & Chung, W. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00079-7 · Cited by 152 · see citing works
Daily consumption of green tea catechin delays memory regression in aged mice
Unno, K., Takabayashi, F., Yoshida, H., Choba, D., Fukutomi, R., Kikunaga, N., Kishido, T., Oku, N., & Hoshino, M. (2006) · Biogerontology · doi:10.1007/s10522-006-9036-8 · Cited by 147 · see citing works
Hung, P.-F., Wu, B.-T., Chen, H.-C., Chen, Y.-H., Chen, C., Wu, M.-H., Liu, H.-C., Lee, M.-J., & Kao, Y.-H. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00569.2004 · Cited by 146 · see citing works
Babu, P. V. A., Sabitha, K. E., & Shyamaladevi, C. S. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.04.009 · Cited by 143 · see citing works
Green tea catechins prevent cognitive deficits caused by Aβ1–40 in rats
Haque, A. M., Hashimoto, M., Katakura, M., Hara, Y., & Shido, O. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.08.008 · Cited by 139 · see citing works
Li, H., Huang, Y., Zhang, C.-N., Liu, G., Wei, Y.-S., Wang, A.-B., Liu, Y.-Q., Hui, R.-T., Wei, C., Williams, G. M., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.005 · Cited by 135 · see citing works
Ho, Y., Yang, S., Peng, C., et al. (2007) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2007.00588.x · Cited by 130 · see citing works
Song, E. K., Hur, H., & Han, M. (2003) · Archives of Pharmacal Research · doi:10.1007/bf02976881 · Cited by 128 · see citing works
EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells
Shimizu, M., Deguchi, A., Hara, Y., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.182 · Cited by 128 · see citing works
Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution
Mukai, K., Nagai, S., & Ohara, K. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.027 · Cited by 127 · see citing works
Osada, K., Takahashi, M., Hoshina, S., Nakamura, M., Nakamura, S., & Sugano, M. (2001) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(00)00192-7 · Cited by 122 · see citing works
Han, M. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.19 · Cited by 120 · see citing works
Hong, Z., Xu, Y., Yin, J., Jin, J., Jiang, Y., & Du, Q. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf504603n · Cited by 120 · see citing works
Shi, J., Liu, F., ZHANG, W., Liu, X., Lin, B., & Tang, X. (2015) · Oncology Reports · doi:10.3892/or.2015.3889 · Cited by 117 · see citing works
Shim, J., Su, Z., Chae, J., et al. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0185 · Cited by 115 · see citing works
Thangapazham, R. L., Passi, N., & Maheshwari, R. K. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.12.4974 · Cited by 112 · see citing works
Zhou, J., Yu, L., Mai, Z., & Blackburn, G. L. (2003) · International Journal of Cancer · doi:10.1002/ijc.11549 · Cited by 109 · see citing works
Ko, H., So, Y., Jeon, H., Jeong, M., Choi, H., Ryu, S.-H., Lee, S.-W., Yoon, H., & Choi, K. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.018 · Cited by 108 · see citing works
Braicu, C., Gherman, C. D., Irimie, A., et al. (2013) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2013.6882 · Cited by 100 · see citing works
Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis
Mann, C. D., Neal, C. P., Garcea, G., Manson, M. M., Dennison, A. R., & Berry, D. P. (2008) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3282f0c090 · Cited by 94 · see citing works
Katiyar, S. K., Agarwal, R., Wang, Z. Y., et al. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514207 · Cited by 93 · see citing works
Deng, Y., & Lin, J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204149c · Cited by 89 · see citing works
Wu, B.-T., Hung, P.-F., Chen, H.-C., et al. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050045p · Cited by 85 · see citing works
Ma, Y., Cui, L., Gao, F., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2933 · Cited by 83 · see citing works
Sommer, A. P., Bieschke, J., Friedrich, R. P., Zhu, D., Wanker, E. E., Fecht, H. ‐., Mereles, D., & HUNSTEIN, W. (2011) · Photomedicine and Laser Surgery · doi:10.1089/pho.2011.3073 · Cited by 83 · see citing works
Fernandez, J. W., Rezai-Zadeh, K. P., Obregon, D. F., & Tan, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.09.022 · Cited by 83 · see citing works
Black and green tea and heart disease: A review
Vinson, J. A. (2000) · BioFactors · doi:10.1002/biof.5520130121 · Cited by 80 · see citing works
Protective effects of green tea catechins on cerebral ischemic damage.
Suzuki, M., Tabuchi, M., Ikeda, M., Umegaki, K., & Tomita, T. (2004) · PubMed · Cited by 79 · see citing works
Awad, A. B., Barta, S. L., Fink, C. S., & Bradford, P. G. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700222 · Cited by 78 · see citing works
Yao, C., Zhang, J., Liu, G., et al. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1778 · Cited by 76 · see citing works
Uchida, S., Ozaki, M., AKASHI, T., Yamashita, K., Niwa, M., & Taniyama, K. (1995) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1995.tb02928.x · Cited by 76 · see citing works
Farabegoli, F., Barbi, C., Lambertini, E., & Piva, R. (2007) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2007.10.018 · Cited by 73 · see citing works
Li, X., Feng, Y., Liu, J., Feng, X., Zhou, K., & Tang, X. (2013) · Lifestyle Genomics · doi:10.1159/000354402 · Cited by 66 · see citing works
Steevens, J., Schouten, L. J., Verhage, B. A. J., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604008 · Cited by 65 · see citing works
Roomi, M. W., Ivanov, V. O., Kalinovsky, T., et al. (2005) · Medical Oncology · doi:10.1385/mo:22:2:129 · Cited by 64 · see citing works
Chao, J., Lau, W. K., Huie, M. J., Ho, J. Y. S., Yu, M.-S., Lai, C. S.-W., Wang, M., Yuen, W.-H., Lam, W. H., Chan, T. H., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.028 · Cited by 63 · see citing works
Wang, S., Chen, R., Zhong, Z., Shi, Z., Chen, M., & Wang, Y. (2014) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x14500803 · Cited by 61 · see citing works
Effects of Epigallocatechin-3-gallate (EGCG) on A549 Lung Cancer Tumor Growth and Angiogenesis
Sakamoto, Y., TERASHITA, N., Muraguchi, T., Fukusato, T., & Kubota, S. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120882 · Cited by 59 · see citing works
Sonoda, J., Ikeda, R., Baba, Y., et al. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1719 · Cited by 58 · see citing works
Green tea epigallocatechin-3-gallate attenuatesPorphyromonas gingivalis-induced atherosclerosis
Cai, Y. C., Kurita‐Ochiai, T., Hashizume, T., et al. (2012) · Pathogens and Disease · doi:10.1111/2049-632x.12001 · Cited by 54 · see citing works
Young, W., HOTOVEC, R. L., & Romero, A. G. (1967) · Nature · doi:10.1038/2161015a0 · Cited by 52 · see citing works
Wang, C., Chang, H.-H., Hsiao, C.-H., Lee, M., Ku, H., Hu, Y.-J., & Kao, Y. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800013 · Cited by 52 · see citing works
Giakoustidis, A. E., Giakoustidis, D. E., Iliadis, S., et al. (2005) · Free Radical Research · doi:10.1080/10715760500133479 · Cited by 51 · see citing works
Ramesh, E., Rajan, E., Muniyan, S., et al. (2008) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00585.x · Cited by 51 · see citing works
Jin, L., Cui, L., Xu, Y., Wang, L., Liu, J., Wang, D., HONG, C., JIANG, Z., Ma, Y., Chen, Q., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2343 · Cited by 51 · see citing works
EGCG Stabilizes p27kip1 in E2-Stimulated MCF-7 Cells through Down-Regulation of the Skp2 Protein
Huang, H., Way, T., Lin, C., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0408 · Cited by 50 · see citing works
Park, J., Bae, J., Im, S.-S., & Song, D. (2013) · Integrative Medicine Research · doi:10.1016/j.imr.2013.12.002 · Cited by 50 · see citing works
Ramesh, E., Geraldine, P., & Thomas, P. A. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.09.013 · Cited by 49 · see citing works
Kim, K.-C., & Lee, C. (2014) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2014.18.1.61 · Cited by 47 · see citing works
Liu, W., Dong, M., Bo, L., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/612593 · Cited by 45 · see citing works
A study on tea pigment in the prevention of atherosclerosis
Lou, F.-Q. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90040-o · Cited by 40 · see citing works
Cromie, M. M., & Gao, W. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/217304 · Cited by 38 · see citing works
The functional effect of epigallocatechin gallate on ischemic stroke in rats
Lim, S. H., Kim, H. S., Kim, Y. K., et al. (2010) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2010-1772 · Cited by 37 · see citing works
Shôji, Y., & Nakashima, H. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02974080 · Cited by 34 · see citing works
Hotta, Y., Huang, L., Muto, T., et al. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.017 · Cited by 34 · see citing works
EGCG decreases the expression of HIF-1α and VEGF and cell growth in MCF-7 breast cancer cells.
Luo, H., Xu, M., Zhong, W., et al. (2014) · PubMed · Cited by 33 · see citing works
Kuo, Y.-C., Yu, C., Liu, C.-Y., et al. (2008) · Cancer Causes & Control · doi:10.1007/s10552-008-9217-7 · Cited by 32 · see citing works
He, M., Liu, M., Wang, S., Tang, Q.-S., Yao, W., Hai-shan, Z., & Wei, M. (2012) · PubMed · Cited by 29 · see citing works
Kim, M.-H., Murakami, A., & Ohigashi, H. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70213 · Cited by 29 · see citing works
Zeng, X., & Tan, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3603 · Cited by 28 · see citing works
Artali, R., Beretta, G., Morazzoni, P., Bombardelli, E., & Meneghetti, F. (2008) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360802177282 · Cited by 27 · see citing works
Ding, J., Fu, G., Zhao, Y., et al. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9758-2 · Cited by 22 · see citing works
Does the Consumption of Green Tea Reduce the Risk of Lung Cancer among Smokers?
Liang, W., Binns, C. W., Jian, L., & Lee, A. H. (2006) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nel066 · Cited by 21 · see citing works
Effects of Metal Ions, Catechins, and Their Interactions on Prostate Cancer
Yu, H., Shen, S., & Yin, J. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390600948873 · Cited by 18 · see citing works
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Chen, Y., Luo, R., Li, J., Wang, S., Ding, J., Zhao, K., Lu, B., & Zhou, W. (2022) · ACS Nano · doi:10.1021/acsnano.1c08913 · Cited by 177 · see citing works
Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases
Kanlaya, R., & Thongboonkerd, V. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy077 · Cited by 99 · see citing works
Ettcheto, M., Cano, A., Manzine, P. R., Busquets, O., Verdaguer, E., Castro-Torres, R. D., García, M. L., Beas-Zarate, C., Olloquequi, J., Auladell, C., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01849-6 · Cited by 73 · see citing works
Potential Valorization of Banana Production Waste in Developing Countries: Bio-Engineering Aspects
Waraczewski, R., & Sołowiej, B. G. (2024) · Fibers · doi:10.3390/fib12090072 · Cited by 10 · see citing works
“Epigallocatechin-3-gallate has been confirmed to prevent diabetes, cancer, cardiac disease, lung disease, and neuro degenerative disease [27].”
- Authors
- Chowdhury, A., Sarkar, J., Chakraborti, T., Pramanik, P. K., & Chakraborti, S.
- Affiliations
- University of Kalyani (IN)
- Corresponding author
- Chakraborti, Sajal
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 78
- Pages
- 50-59
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2233311515
- Cited by
- 164
- References
- 141
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 9 · 2022: 17 · 2021: 14 · 2020: 16 · 2019: 26 · 2018: 14 · 2017: 27 · 2016: 10
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council for Industrial Research (CSIR), Govt of India
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- epigallocatechin gallate, tea polyphenols, cancer prevention, cardiovascular disease, neurodegenerative diseases, cellular signaling pathways, molecular mechanisms, chronic disease prevention, antioxidant activity
- MeSH terms
- Animals, Catechin, Disease, Health, Humans, Models, Biological, Protective Agents
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