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Cited by 184Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismNatural Products and Biological Research

The DOI matches its Crossref record; 63 of the 65 references it cites were found in a registry or an index.

Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia

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Jenkins, David JA, Kendall, Cyril WC, Faulkner, Dorothea A, Nguyen, Tri, Kemp, Thomas, Marchie, Augustine, Wong, Julia MW, de Souza, Russell, Emam, Azadeh, Vidgen, Edward, Trautwein, Elke A, Lapsley, Karen G, Holmes, Candice, Josse, Robert G, Leiter, Lawrence A, Connelly, Philip W, Singer, William·2006·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn.83.3.582
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Abstract

Background Cholesterol-lowering foods may be more effective when consumed as combinations rather than as single foods.Objectives Our aims were to determine the effectiveness of consuming a combination of cholesterol-lowering foods (dietary portfolio) under real-world conditions and to compare these results with published data from the same participants who had undergone 4-wk metabolic studies to compare the same dietary portfolio with the effects of a statin.Design For 12 mo, 66 hyperlipidemic participants were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal), and almonds (23 g/1000 kcal). Fifty-five participants completed the 1-y study. The 1-y data were also compared with published results on 29 of the participants who had also undergone separate 1-mo metabolic trials of a diet and a statin.Results At 3 mo and 1 y, mean (+/-SE) LDL-cholesterol reductions appeared stable at 14.0 +/- 1.6% (P < 0.001) and 12.8 +/- 2.0% (P < 0.001), respectively (n = 66). These reductions were less than those observed after the 1-mo metabolic diet and statin trials. Nevertheless, 31.8% of the participants (n = 21 of 66) had LDL-cholesterol reductions of >20% at 1 y (x +/- SE: -29.7 +/- 1.6%). The LDL-cholesterol reductions in this group were not significantly different from those seen after their respective metabolically controlled portfolio or statin treatments. A correlation was found between total dietary adherence and LDL-cholesterol change (r = -0.42, P < 0.001). Only 2 of the 26 participants with <55% compliance achieved LDL-cholesterol reductions >20% at 1 y.Conclusions More than 30% of motivated participants who ate the dietary portfolio of cholesterol-lowering foods under real-world conditions were able to lower LDL-cholesterol concentrations >20%, which was not significantly different from their response to a first-generation statin taken under metabolically controlled conditions.

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Authors
Jenkins, D. J., Kendall, C. W., Faulkner, D. A., Nguyen, T., Kemp, T., Marchie, A., Wong, J. M., de Souza, R., Emam, A., Vidgen, E., Trautwein, E. A., Lapsley, K. G., Holmes, C., Josse, R. G., Leiter, L. A., Connelly, P. W., & Singer, W.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Kendall, Cyril WC
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2006-03
Volume
83
Issue
3
Pages
582-591
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn.83.3.582
OpenAlex
W2182342318
Cited by
184
References
65
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 6
FWCI
18.30
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Keywords
hypercholesterolemia, LDL cholesterol lowering, phytosterols, soy protein, almond, dietary adherence, statin comparison, long-term dietary intervention, hyperlipidemia
MeSH terms
Adult, Aged, Aged, 80 and over, Anticholesteremic Agents, Cholesterol, Dietary, Combined Modality Therapy, Dietary Fiber, Female, Humans, Hypercholesterolemia, Cholesterol, LDL, Male, Middle Aged, Patient Compliance, Phytosterols, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Prunus, Soybean Proteins

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