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Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice
Abstract
The thymus and spleen of genetically obese (C57BL/6J ob/ob) mice weighed less and contained fewer mononuclear cells and Thy 1.2-positive lymphocytes compared with findings in lean controls. The number of splenic antibody forming cells, particularly IgG-producing lymphocytes, was reduced. There was a marked increase in natural killer cell activity and a slight increase in antibody-dependent cell-mediated cytotoxicity in the obese animals. Cytotoxic response of spleen cells of obese mice immunized in vivo was markedly lower than that of lean controls, whereas the generation of T killer cells against alloantigens after in vitro immunization was unimpaired, which points to a deleterious "microenvironment" in obesity. It is suggested that metabolic, nutritional, and endocrine changes in obesity may contribute to altered immunocompetence.
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“Obesity and diabetes are associated with suppression of cell activities central to launching adaptive immune responses, and increase the risk of vaccine failure and severe infection (Allard et al., 2010; Chandra, 1980; Smith et al., 2009; Eliakim et al., 2006; Sheridan et al., 2012).”
From On race, human variation, and who gets and dies of sepsis (2022) · cites this paper as Chandra, 1980
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Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Metabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Impact of Obesity and Metabolic Syndrome on Immunity
Andersen, C. J., Murphy, K. E., & Fernandez, M. L. (2016) · Advances in Nutrition · doi:10.3945/an.115.010207 · Cited by 701
Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664
Obesity and immune function relationships
Martí, A., Marcos, A., & Martínez, J. A. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00025.x · Cited by 418
Metadata
- Authors
- Chandra, R. K.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1980-01
- Volume
- 33
- Issue
- 1
- Pages
- 13-16
- ISSN
- 0002-9165
- Cited by
- 134
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice. https://app.cochat.ai/papers/10.1093/ajcn/33.1.13
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- Chandra, R. K. (1980). Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice. The American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/33.1.13
