A reanalysis of the factors influencing basal metabolic rate in normal adults
Abstract
A multiple regression analysis of several factors influencing basal metabolic rate (BMR) was performed using data for 223 subjects from the classic metabolism studies published by Harris and Benedict in 1919. These data had previously been analyzed by Kleiber using metabolic body size, the three-fourths power of body mass, as a predictor of BMR. His prediction equations were separated by sex and each contained components for age and height. Factors in the present analysis included sex, age, height, body mass, and estimated lean body mass (LBM). Lean body mass was found to be the single predictor of BMR. A best estimate prediction equation: BMR(cal/day) = 500 + 22 (LBM) is proposed. The previously presumed influences of sex and age are shown to add little to this estimation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The Mayo investigators used a combination of normal, free-living subjects and 'hospital normal' subjects.
“The investigators used a combination of normal, free-living subjects and 'hospital normal' subjects.”
From Basal metabolic rate studies in humans: measurement and development of new equations (2005) · cites this paper as [33]
The hospital normal subjects were not seriously ill but were not all 'normal' free-living subjects.
“While the subjects admitted to hospital were not seriously ill, they nevertheless highlight the point that the subjects were not all 'normal' free-living subjects 33,34 .”
From Basal metabolic rate studies in humans: measurement and development of new equations (2005) · cites this paper as [33]
Cited by
Sorted by citations
A new predictive equation for resting energy expenditure in healthy individuals
Mifflin, M., St Jeor, S., Hill, L., Scott, B., Daugherty, S., & Koh, Y. (1990) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.2.241 · Cited by 2,544 · see citing works
Thomas, D. T., Erdman, K. A., & Burke, L. M. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2015.12.006 · Cited by 1,359 · see citing works
Nutrition and Athletic Performance
(2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000852 · Cited by 1,305 · see citing works
Nutrition and Athletic Performance
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31890eb86 · Cited by 1,084 · see citing works
Basal metabolic rate studies in humans: measurement and development of new equations
Henry, C. (2005) · Public Health Nutrition · doi:10.1079/phn2005801 · Cited by 1,033 · see citing works
Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review
Carroll, P. V., Christ the members of Growth Hormon, E. R., Bengtsson, B. Å., Carlsson, L., Christiansen, J. S., Clemmons, D., Hintz, R., Ho, K., Laron, Z., Sizonenko, P., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4594 · Cited by 822 · see citing works
Cunningham, J. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.963 · Cited by 607 · see citing works
Self-citationRe-Examination of the “3/4-Law” of Metabolism
DODDS, P. S., ROTHMAN, D. H., & WEITZ, J. S. (2001) · Journal of Theoretical Biology · doi:10.1006/jtbi.2000.2238 · Cited by 589 · see citing works
Kroke, A., Klipstein-Grobusch, K., Voss, S., Möseneder, J., Thielecke, F., Noack, R., & Boeing, H. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.4.439 · Cited by 550 · see citing works
Rees, D., Miles, E. A., Banerjee, T., Wells, S. J., Roynette, C. E., Wahle, K. W., & Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.331 · Cited by 401 · see citing works
Familial Dependence of the Resting Metabolic Rate
Bogardus, C., Lillioja, S., Ravussin, E., Abbott, W., Zawadzki, J. K., Young, A., Knowler, W. C., Jacobowitz, R., & Moll, P. P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607103150205 · Cited by 398 · see citing works
Müller, M. J., Bosy-Westphal, A., Klaus, S., Kreymann, G., Lührmann, P. M., Neuhäuser-Berthold, M., Noack, R., Pirke, K. M., Platte, P., Selberg, O., et al. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1379 · Cited by 351 · see citing works
Heymsfield, S. B., Gallagher, D., Kotler, D. P., Wang, Z., Allison, D. B., & Heshka, S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e132 · Cited by 262 · see citing works
Speakman, J. R., & Westerterp, K. R. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28540 · Cited by 198 · see citing works
Energy expenditure in chronic spinal cord injury
Buchholz, A. C., & Pencharz, P. B. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200411000-00008 · Cited by 176 · see citing works
Is obesity associated with altered energy expenditure?
Carneiro, I. P., Elliott, S. A., Siervo, M., Padwal, R., Bertoli, S., Battezzati, A., & Prado, C. M. (2016) · Advances in Nutrition · doi:10.3945/an.115.008755 · Cited by 169 · see citing works
Determinants of Oxygen Uptake: Implications for Exercise Testing
Poole, D. C., & Richardson, R. S. (1997) · Sports Medicine · doi:10.2165/00007256-199724050-00003 · Cited by 152 · see citing works
Effects of meal frequency on weight loss and body composition: a meta-analysis
Jon Schoenfeld, B., Albert Aragon, A., & Krieger, J. W. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu017 · Cited by 127 · see citing works
Sustained depression of the resting metabolic rate after massive weight loss
Elliot, D. L., Goldberg, L., Kuehl, K. S., & Bennett, W. M. (1989) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.1.93 · Cited by 131 · see citing works
Sabounchi, N. S., Rahmandad, H., & Ammerman, A. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.218 · Cited by 135 · see citing works
Burke, L. M. (2001) · Canadian Journal of Applied Physiology · doi:10.1139/h2001-055 · Cited by 112 · see citing works
Staal, S., Sjödin, A., Fahrenholtz, I., Bonnesen, K., & Melin, A. K. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0327 · Cited by 101 · see citing works
Nielsen, S., Hensrud, D., Romanski, S., Levine, J., Burguera, B., & Jensen, M. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801317 · Cited by 93 · see citing works
Lean Body Mass is a Predictor of the Daily Requirement for Thyroid Hormone in Older Men and Women
CUNNINGHAM, J. J., & BARZEL, U. S. (1984) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1984.tb02003.x · Cited by 80 · see citing works
Self-citationWhite, L. J., Ferguson, M. A., McCoy, S. C., & Kim, H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031006 · Cited by 81 · see citing works
Roubenoff, R., Hughes, V. A., Dallal, G. E., Nelson, M. E., Morganti, C., Kehayias, J. J., Singh, M. A. F., & Roberts, S. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m757 · Cited by 55 · see citing works
A Practical Equation to Predict Resting Metabolic Rate in Older Females
Arciero, P. J., Goran, M. I., Gardner, A. M., Ades, P. A., Tyzbir, R. S., & Poehlman, E. T. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb06946.x · Cited by 52 · see citing works
Influence of age on the thermic response to caffeine in women
Arciero, P. J., Bougopoulos, C. L., Nindl, B. C., & Benowitz, N. L. (2000) · Metabolism · doi:10.1016/s0026-0495(00)90888-6 · Cited by 34 · see citing works
Larsen, M. S., Clausen, D., Jørgensen, A. A., Mikkelsen, U. R., & Hansen, M. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0286 · Cited by 14 · see citing works
Kramer, R., Schellen, L., Schellen, H., & Kingma, B. (2017) · Temperature · doi:10.1080/23328940.2017.1301851 · Cited by 12 · see citing works
- Authors
- Cunningham, J. J.
- Corresponding author
- Cunningham, J J
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1980-11
- Volume
- 33
- Issue
- 11
- Pages
- 2372-2374
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2107036615
- Cited by
- 545
- References
- 0
- Citations by year
- 2026: 24 · 2025: 21 · 2024: 31 · 2023: 35 · 2022: 27 · 2021: 35 · 2020: 27 · 2019: 23 · 2018: 15 · 2017: 23 · 2016: 20 · 2015: 14 · 2014: 14 · 2013: 16 · 2012: 13
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- basal metabolic rate, Harris-Benedict equation, Kleiber's law, metabolic body size, lean body mass, body mass, sex differences, age effects, height, prediction equations, energy expenditure
- MeSH terms
- Adolescent, Adult, Aging, Basal Metabolism, Body Constitution, Body Height, Body Surface Area, Body Weight, Female, Humans, Male, Sex Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review