Effects of a low-insulin-response, energy-restricted diet on weight loss and plasma insulin concentrations in hyperinsulinemic obese females
Abstract
The effects of two low-energy diets on serum insulin concentrations and weight loss in obese hyperinsulinemic females were compared during a 12-wk period. The first diet (n = 15) was designed to evoke a low insulin response (ID), and the second (n = 15) was a conventionally balanced diet (ND). After a 12-wk washout period, seven and nine subjects who had been on the ID and ND, respectively, changed to the alternative diet for 12 wk. Variables studied were basal and 30- and 120-min concentrations of blood glucose, insulin, and C-peptide after an oral glucose load; body weight; and energy intake. Mean (+/- SD) weight was significantly reduced after ID and ND (9.35 +/- 2.49 and 7.41 +/- 4.23, respectively). The mean weight loss was more after ID. Fasting insulin concentrations decreased more after ID compared with ND (91.3 +/- 61.8 vs 21.0 +/- 71.5 pmol/L; P < 0.05). We conclude that ID significantly reduces serum insulin concentrations and weight in obese hyperinsulinemic females.
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Diets with high GI or high GL are associated with increased risk of insulin resistance, dyslipidaemia, and development of CVD and type 2 diabetes.
“A growing body of research resulting from dietary trials and large epidemiological studies indicates that diets with a high GI or high GL are associated with an increased risk of insulin resistance, dyslipidaemia, and the development of CVD and type 2 diabetic subjects (Slabber et al. 1994;Salmeron et al. 1997a,b;Frost et al. 1999).”
From Glycaemic index methodology (2005) · cites this paper as Slabber et al. 1994
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- Authors
- Slabber, M., Barnard, H., Kuyl, J., Dannhauser, A., & Schall, R.
- Affiliations
- University of the Free State (ZA)
- Corresponding author
- Slabber, M
- ORCID
- Schall, R
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 60
- Issue
- 1
- Pages
- 48-53
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2121593233
- Cited by
- 190
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- hypocaloric diet, weight loss, hyperinsulinemia, obesity, insulin resistance, plasma insulin, C-peptide, oral glucose tolerance, body weight, energy intake
- MeSH terms
- Adult, Blood Glucose, C-Peptide, Energy Intake, Diabetes Mellitus, Diet, Diabetic, Fasting, Female, Humans, Hyperinsulinism, Insulin, Obesity, Weight Loss, Body Mass Index, Diabetes Complications
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