The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Fat and carbohydrate overfeeding in humans: different effects on energy storage
Abstract
Both the amount and composition of food eaten influence body-weight regulation. The purpose of this study was to determine whether and by what mechanism excess dietary fat leads to greater fat accumulation than does excess dietary carbohydrate. We overfed isoenergetic amounts (50% above energy requirements) of fat and carbohydrate (for 14 d each) to nine lean and seven obese men. A whole-room calorimeter was used to measure energy expenditure and nutrient oxidation on days 0, 1, 7, and 14 of each overfeeding period. From energy and nutrient balances (intake-expenditure) we estimated the amount and composition of energy stored. Carbohydrate overfeeding produced progressive increases in carbohydrate oxidation and total energy expenditure resulting in 75-85% of excess energy being stored. Alternatively, fat overfeeding had minimal effects on fat oxidation and total energy expenditure, leading to storage of 90-95% of excess energy. Excess dietary fat leads to greater fat accumulation than does excess dietary carbohydrate, and the difference was greatest early in the overfeeding period.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“An adaptive process of several weeks has also been observed with more moderate, nonketogenic macronutrient changes (150–152).”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [150]
Citations
Cites
DENSITOMETRIC ANALYSIS OF BODY COMPOSITION: REVISION OF SOME QUANTITATIVE ASSUMPTIONS*
Brožek, J., Grande, F., Anderson, J. T., & Keys, A. B. (1963) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1963.tb17079.x · Cited by 2,263
Bruce, R. A., Kusumi, F., & Hosmer, D. W. (1973) · American Heart Journal · doi:10.1016/0002-8703(73)90502-4 · Cited by 2,057
The Response to Long-Term Overfeeding in Identical Twins
Bouchard, C., Tremblay, A., Després, J.-P., Nadeau, A., Lupien, P. J., Thériault, G., Dussault, J., Moorjani, S., Pinault, S., & Fournier, G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222101 · Cited by 1,278
Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ
ZURLO, F., Lillioja, S., Puente, A. E.-D., Nyomba, B. L. G., Raz, I., Saad, M. F., Swinburn, B. A., Knowler, W. C., Bogardus, C., & Ravussin, É. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.5.e650 · Cited by 709
Assessment of Energy Expenditure and Fuel Utilization in Man
Jéquier, E., Acheson, K. J., & Schütz, Y. (1987) · Annual Review of Nutrition · doi:10.1146/annurev.nu.07.070187.001155 · Cited by 532
Dietary fat and serum lipids: an evaluation of the experimental data
Hegsted, D., Ausman, L., Johnson, J., & Dallal, G. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.6.875 · Cited by 515
Dietary fat and the regulation of energy intake in human subjects
Lissner, L., Levitsky, D. A., Strupp, B. J., Kalkwarf, H. J., & Roe, D. A. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.6.886 · Cited by 502
Techniques for Measuring Body Composition.
Forbes, G. B. (1962) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1962.02080030207026 · Cited by 500
Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances.
Flatt, J. P., Ravussin, É., Acheson, K. J., & Jéquier, E. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112054 · Cited by 412
Measurement of de novo hepatic lipogenesis in humans using stable isotopes.
Hellerstein, M. K., Christiansen, M., Kaempfer, S., Kletke, C., Wu, K. K., Reid, J., Mulligan, K. M., Hellerstein, N. S., & Shackleton, C. H. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115206 · Cited by 362
Research works printed but not linked: 1
- Schwartz, 1993, Effect of oral fructose on lipolysis, fat oxidation, fractional and absolute de novo lipogenesis (DNL) using mass isotopomer distribution analysis (MIDA)., FASEB J, 7, A867
Cited by
Sorted by citations
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180
Self-citationHill, J. O., Wyatt, H. R., & Peters, J. C. (2012) · Circulation · doi:10.1161/circulationaha.111.087213 · Cited by 1,317
Self-citationDiet, nutrition and the prevention of excess weight gain and obesity
Ba, S., Caterson, I. D., Seidell, J. C., & James, W. P. T. (2004) · Public Health Nutrition · doi:10.1079/phn2003585 · Cited by 1,150
Dietary fat intake does affect obesity!
Bray, G. A., & Popkin, B. M. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1157 · Cited by 1,123
Fructose, weight gain, and the insulin resistance syndrome,,
Elliott, S. S., Keim, N. L., Stern, J. S., Teff, K. L., & Havel, P. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.911 · Cited by 1,031
Metadata
- Authors
- Horton, T., Drougas, H., Brachey, A., Reed, G., Peters, J., & Hill, J.
- Affiliations
- University of Colorado Health (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 62
- Issue
- 1
- Pages
- 19-29
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1952443362
- Cited by
- 339
- References
- 38
- Citations by year
- 2026: 7 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 7 · 2017: 16 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 11
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-42549)
- National Center for Research Resources (RR00095)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- energy storage, fat deposition, energy expenditure, carbohydrate oxidation, fat oxidation, nutrient oxidation, body weight regulation, obesity, lean men, energy balance
- MeSH terms
- Adolescent, Adult, Blood Glucose, Body Composition, Body Weight, Calorimetry, Dietary Carbohydrates, Dietary Fats, Energy Metabolism, Fasting, Fatty Acids, Nonesterified, Humans, Hyperphagia, Insulin, Male, Middle Aged, Obesity, Oxidation-Reduction, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
