Cited by 339Regulation of Appetite and ObesityDiet, Metabolism, and DiseaseMuscle metabolism and nutrition

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Fat and carbohydrate overfeeding in humans: different effects on energy storage

Horton, TJ, Drougas, H, Brachey, A, Reed, GW, Peters, JC, Hill, JO·1995·The American Journal of Clinical Nutrition

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Abstract

Both the amount and composition of food eaten influence body-weight regulation. The purpose of this study was to determine whether and by what mechanism excess dietary fat leads to greater fat accumulation than does excess dietary carbohydrate. We overfed isoenergetic amounts (50% above energy requirements) of fat and carbohydrate (for 14 d each) to nine lean and seven obese men. A whole-room calorimeter was used to measure energy expenditure and nutrient oxidation on days 0, 1, 7, and 14 of each overfeeding period. From energy and nutrient balances (intake-expenditure) we estimated the amount and composition of energy stored. Carbohydrate overfeeding produced progressive increases in carbohydrate oxidation and total energy expenditure resulting in 75-85% of excess energy being stored. Alternatively, fat overfeeding had minimal effects on fat oxidation and total energy expenditure, leading to storage of 90-95% of excess energy. Excess dietary fat leads to greater fat accumulation than does excess dietary carbohydrate, and the difference was greatest early in the overfeeding period.

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Authors: Horton, T., Drougas, H., Brachey, A., Reed, G., Peters, J., & Hill, J.
Affiliations: University of Colorado Health (US)
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 1995-07
Volume: 62
Issue: 1
Pages: 19-29
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/62.1.19
OpenAlex: W1952443362
Cited by: 339
References: 38
Citations by year: 2026: 7 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 7 · 2017: 16 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 11
FWCI: 5.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-42549)
National Center for Research Resources (RR00095)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: energy storage, fat deposition, energy expenditure, carbohydrate oxidation, fat oxidation, nutrient oxidation, body weight regulation, obesity, lean men, energy balance
MeSH terms: Adolescent, Adult, Blood Glucose, Body Composition, Body Weight, Calorimetry, Dietary Carbohydrates, Dietary Fats, Energy Metabolism, Fasting, Fatty Acids, Nonesterified, Humans, Hyperphagia, Insulin, Male, Middle Aged, Obesity, Oxidation-Reduction, Cross-Over Studies

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Fat and carbohydrate overfeeding in humans: different effects on energy storage

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