Cited by 515Fatty Acid Research and HealthCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Dietary fat and serum lipids: an evaluation of the experimental data

Hegsted, DM, Ausman, LM, Johnson, JA, Dallal, GE·1993·The American Journal of Clinical Nutrition

Abstract

Regression analysis of the combined published data on the effects of dietary fatty acids and cholesterol on serum cholesterol and lipoprotein cholesterol evaluated with groups of human subjects shows that 1) saturated fatty acids increase and are the primary determinants of serum cholesterol, 2) polyunsaturated fatty acids actively lower serum cholesterol, 3) monounsaturated fatty acids have no independent effect on serum cholesterol and, 4) dietary cholesterol increases serum cholesterol and must be considered when the effects of fatty acids are evaluated. More limited data on low-density-lipoprotein cholesterol (LDL-C) show that changes in LDL-C roughly parallel the changes in serum cholesterol but that changes in high-density-lipoprotein cholesterol cannot be satisfactorily predicted from available data.

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Crossref · 10.1093/ajcn/57.6.875

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1 of 1 references verified0 citation errors · 0 not checkable

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Authors
Hegsted, D., Ausman, L., Johnson, J., & Dallal, G.
Affiliations
Tufts University (US)
Corresponding author
Hegsted, DM
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1993-06
Volume
57
Issue
6
Pages
875-883
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2147536017
Cited by
515
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 14 · 2016: 3 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 16
FWCI
28.32
Type
journal article
Language
en
Update notices
erratum (1993-08-01)
Open access
closed
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (RR00 168)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
dietary fat, serum cholesterol, lipoprotein cholesterol, saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, dietary cholesterol, LDL cholesterol, HDL cholesterol, dietary fatty acids
MeSH terms
Dietary Fats, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Regression Analysis

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