Dietary fat and serum lipids: an evaluation of the experimental data
Abstract
Regression analysis of the combined published data on the effects of dietary fatty acids and cholesterol on serum cholesterol and lipoprotein cholesterol evaluated with groups of human subjects shows that 1) saturated fatty acids increase and are the primary determinants of serum cholesterol, 2) polyunsaturated fatty acids actively lower serum cholesterol, 3) monounsaturated fatty acids have no independent effect on serum cholesterol and, 4) dietary cholesterol increases serum cholesterol and must be considered when the effects of fatty acids are evaluated. More limited data on low-density-lipoprotein cholesterol (LDL-C) show that changes in LDL-C roughly parallel the changes in serum cholesterol but that changes in high-density-lipoprotein cholesterol cannot be satisfactorily predicted from available data.
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Predictive regression equations generally include regression coefficients showing that SFA increases LDL cholesterol twice as much as PUFA reduces LDL cholesterol.
“These equations generally include regression coefficients that show SFA increases LDL cholesterol twice as much as PUFA reduces LDL cholesterol [[12], [13], [14]].”
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- Authors
- Hegsted, D., Ausman, L., Johnson, J., & Dallal, G.
- Affiliations
- Tufts University (US)
- Corresponding author
- Hegsted, DM
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 57
- Issue
- 6
- Pages
- 875-883
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2147536017
- Cited by
- 515
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 14 · 2016: 3 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 16
- FWCI
- 28.32
- Type
- journal article
- Language
- en
- Update notices
- erratum (1993-08-01)
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR00 168)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- dietary fat, serum cholesterol, lipoprotein cholesterol, saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, dietary cholesterol, LDL cholesterol, HDL cholesterol, dietary fatty acids
- MeSH terms
- Dietary Fats, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Regression Analysis
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