Vitamin C and the risk of acute myocardial infarction
Open accessAbstract
Background Low-fat soluble-antioxidant status is associated with an increased risk of heart disease.Objective The aim of this study was to examine whether low plasma concentrations of vitamin C confer an independent risk of acute myocardial infarction (AMI).Design Male patients (n = 180) aged <65 y with a first AMI and without an existing diagnosis of angina (>6 mo) who were admitted within 12 h after onset of symptoms were compared with apparently healthy volunteers (n = 177). Plasma concentrations and dietary intakes of vitamin C were determined during hospitalization and 3 mo later.Results Compared with the control subjects, the patients had higher total cholesterol and lower HDL-cholesterol concentrations and more of them smoked. The relative risk of AMI for the lowest compared with the highest quintile of plasma vitamin C during hospitalization (14.5 and >60.5 micromol/L, respectively) was 8.37 (95% CI: 3.28, 21. 4) after adjustment for classic risk factors. At 3 mo, mean (+/-SEM) plasma vitamin C concentrations in patients had increased significantly, from 19.6 +/- 1.2 to 35.1 +/- 1.9 micromol/L (P < 0. 001) and no longer conferred a risk of AMI [relative risk: 1.02 (95% CI: 0.51, 2.03)]. Habitual dietary vitamin C intake of patients (before AMI) did not differ significantly from that of control subjects. The increase in plasma vitamin C after recovery from the infarction could not be explained by a similarly large increase in dietary vitamin C.Conclusions A low plasma concentration of vitamin C was not associated with an increased risk of AMI, irrespective of smoking status. The apparent risk of AMI due to a low plasma vitamin C concentration was distorted by the acute phase response.
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Acute myocardial infarction is associated with rapid loss of vitamin C both in plasma and tissues.
“Furthermore, acute myocardial infarction is associated with rapid loss of vitamin C both in plasma and tissues [60,174].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [60]
Ex-smoking seems to slightly decrease vitamin C plasma levels as well.
“Ex-smoking seems to slightly decrease the levels as well [52,60].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [60]
There is no difference between serum and plasma vitamin C levels.
“There is no difference between serum and plasma [59,60,61,62,63].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [60]
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- Authors
- Riemersma, R. A., Carruthers, K. F., Elton, R. A., & Fox, K. A.
- Affiliations
- Edinburgh Royal Infirmary (GB)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 71
- Issue
- 5
- Pages
- 1181-1186
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2162002125
- Cited by
- 50
- References
- 32
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2021: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- vitamin C, acute myocardial infarction, plasma vitamin C concentration, dietary vitamin C intake, acute phase response, antioxidant status, cardiovascular risk factors, smoking, HDL cholesterol, total cholesterol
- MeSH terms
- Adult, Ascorbic Acid, Blood Pressure, Cholesterol, Humans, Cholesterol, HDL, Male, Middle Aged, Myocardial Infarction, Surveys and Questionnaires, Risk Factors, Scotland, Smoking, Social Class, Triglycerides, Cohort Studies
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