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Cardiovascular Toxicity of Nicotine: Implications for Nicotine Replacement Therapy 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.

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Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

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Nitric Oxide Production Is Reduced in Patients With Chronic Renal Failure

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Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2)

Kuntić, M., Oelze, M. W., Steven, S., Kröller‐Schön, S., Stamm, P., Kalinovic, S., Frenis, K., Vujačić-Mirski, K., Jiménez, M. T. B., Kvandová, M., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz772 · Cited by 217 · see citing works

Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?

Jansen, T., & Daiber, A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00030 · Cited by 212 · see citing works

Absorption, transport, and disposition of ascorbic acid in humans

Rumsey, S. C., & Levine, M. (1998) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00002-3 · Cited by 210 · see citing works

Nutraceuticals, Vitamins, Antioxidants, and Minerals in the Prevention and Treatment of Hypertension

Houston, M. C. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.01.004 · Cited by 208 · see citing works

Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats

Odigie, I. P., Ettarh, R., & Adigun, S. A. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00078-3 · Cited by 207 · see citing works

Cigarette Smoking and Hepatic Lesions in Patients With Chronic Hepatitis C

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Vitamin C Deficiency and Depletion in the United States: The Third National Health and Nutrition Examination Survey, 1988 to 1994

Hampl, J. S., Taylor, C. A., & Johnston, C. S. (2004) · American Journal of Public Health · doi:10.2105/ajph.94.5.870 · Cited by 203 · see citing works

The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function

Maas, R., Schwedhelm, E., Albsmeier, J., & Böger, R. H. (2002) · Vascular Medicine · doi:10.1191/1358863x02vm429ra · Cited by 199 · see citing works

Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease

Schmidt, T. S., & Alp, N. J. (2007) · Clinical Science · doi:10.1042/cs20070108 · Cited by 195 · see citing works

Beneficial effects of α-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress

Heitzer, T. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00551-2 · Cited by 194 · see citing works

The Role of Natural Antioxidants in Preserving the Biological Activity of Endothelium-Derived Nitric Oxide

Carr, A., & Frei, B. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00225-2 · Cited by 190 · see citing works

Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production

Skatchkov, M. P., Sperling, D., Hink, U., Mülsch, A., Harrison, D. G., Sindermann, I., Meinertz, T., & Münzel, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9942 · Cited by 188 · see citing works

Vitamin C status and mortality in US adults

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Nutraceutical therapies for atherosclerosis

Moss, J. W. E., & Ramji, D. P. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.103 · Cited by 186 · see citing works

Cigarette Smoking and Atherosclerotic Cardiovascular Disease

Ishida, M., Sakai, C., Kobayashi, Y., & Ishida, T. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv22015 · Cited by 187 · see citing works

Oxidative stress and accelerated vascular aging: implications for cigarette smoking

Csiszár, A. (2009) · Frontiers in bioscience · doi:10.2741/3440 · Cited by 183 · see citing works

Contribution of nicotine to acute endothelial dysfunction in long-term smokers

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Effects of Long-term Smoking on Myocardial Blood Flow, Coronary Vasomotion, and Vasodilator Capacity

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Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats

Korkmaz, A., Ahbab, M. A., Kolankaya, D., & Barlas, N. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.07.019 · Cited by 178 · see citing works

Green Coffee Bean Extract and Its Metabolites Have a Hypotensive Effect in Spontaneously Hypertensive Rats

Suzuki, A., Kagawa, D., OCHIAI, R., Tokimitsu, I., & Saito, I. (2002) · Hypertension Research · doi:10.1291/hypres.25.99 · Cited by 175 · see citing works

Impact of tobacco smoking and smoking cessation on cardiovascular risk and disease

Bullen, C. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.6.883 · Cited by 173 · see citing works

Micronutrient Deficiencies: A Major Cause of DNA Damage

Ames, B. N. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08727.x · Cited by 171 · see citing works

Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina

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Vitamin C and Cardiovascular Disease: An Update

Morelli, M. B., Gambardella, J., Castellanos, V., Trimarco, V., & Santulli, G. (2020) · Antioxidants · doi:10.3390/antiox9121227 · Cited by 169 · see citing works

Cigarette smoke-induced endothelium dysfunction: role of superoxide anion

Raij, L. R., DeMaster, E. G., & Jaimes, E. A. (2001) · Journal of Hypertension · doi:10.1097/00004872-200105000-00009 · Cited by 165 · see citing works

Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential

Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., & Grumezescu, A. M. (2025) · Molecules · doi:10.3390/molecules30030748 · Cited by 161 · see citing works

Endothelial dysfunction and cardiovascular risk factors

Grover‐Páez, F., & Zavalza-Gómez, A. B. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.12.013 · Cited by 160 · see citing works

Hypoxia Impairs Systemic Endothelial Function in Individuals Prone to High-Altitude Pulmonary Edema

Berger, M. M., Hesse, C., Dehnert, C., Siedler, H., Kleinbongard, P., Bardenheuer, H. J., Kelm, M., Bärtsch, P., & Haefeli, W. E. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-654oc · Cited by 160 · see citing works

Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture

Chalouhi, N., Ali, M. S., Starke, R. M., Jabbour, P. M., Tjoumakaris, S. I., Gonzalez, L. F., Rosenwasser, R. H., Koch, W. J., & Dumont, A. S. (2012) · Mediators of Inflammation · doi:10.1155/2012/271582 · Cited by 158 · see citing works

The Role of Oxidative Stress in Cerebral Aneurysm Formation and Rupture

Starke, R. M., Chalouhi, N., Ali, M. S., Jabbour, P. M., Tjoumakaris, S. I., Gonzalez, L. F., Rosenwasser, R. H., Koch, W. J., & Dumont, A. S. (2013) · Current Neurovascular Research · doi:10.2174/15672026113109990003 · Cited by 158 · see citing works

On the Role of Vitamin C and Other Antioxidants in Atherogenesis and Vascular Dysfunction

Frei, B. B. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-136.x · Cited by 158 · see citing works

Effect of Chronic Oral Supplementation with Vitamins on the Endothelial Function in Chronic Smokers

Takase, B., Etsuda, H., Matsushima, Y., Ayaori, M., Kusano, H., Hamabe, A., Uehata, A., Ohsuzu, F., Ishihara, M., & Kurita, A. (2004) · Angiology · doi:10.1177/00033197040550i606 · Cited by 19 · see citing works

W03-P-011 Chronic smoking is associated with endothelial dysfunction, increased inflammatory process and abnormalities in thrombosis/fibrinolysis system

Toutouza, M., Antoniades, C. A., Vasiliadou, C., Tousoulis, D., Vasiliadis, A., Pitsavos, C., & Stefanadis, C. (2005) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(05)80058-3

Vitamin C Has No Effect on Endothelium-Dependent Vasomotion and Acute Endogenous Fibrinolysis in Healthy Smokers

Pellegrini, M. P., Newby, D. E., Johnston, N. R., Maxwell, S. R. J., & Webb, D. J. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200407000-00016 · Cited by 24 · see citing works

Endothelium-dependent vasodilation in the brachial artery is impaired in smokers: effect of vitamin C

Motoyama, T., Kawano, H., Kugiyama, K., Hirashima, O., Ohgushi, M., Yoshimura, M., Ogawa, H., & Yasue, H. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1644 · Cited by 128 · see citing works

Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers

Tousoulis, D. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00250-8 · Cited by 60 · see citing works