The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects
Open accessAbstract
Background Persons following current dietary guidelines have a lower risk of mortality from coronary heart disease.Objective The objective was to compare the short-term effect of a high-fat meal and a high-carbohydrate meal, with and without dietary antioxidants, on vasomotor, antiplatelet, and hemostatic functions of the endothelium in healthy subjects.Design In an observer-blinded, randomized crossover study, 25 (13 men and 12 women) healthy subjects were given each of 3 meals in random order at 1-wk intervals: a high-fat meal (760 kcal), an isoenergetic high-carbohydrate meal, and a high-fat meal with dietary antioxidants from vegetables (865 kcal). Endothelial functions, as assessed by hemodynamic and rheologic responses to L-arginine--the natural precursor of nitric oxide--were evaluated before and 4 h after each meal.Results Unlike the high-carbohydrate meal, the high-fat meal increased the plasma concentrations of triacylglycerol (P < 0.01); both meals activated hemostasis. The high-carbohydrate meal did not modify blood pressure, and platelet aggregation decreased in response to the L-arginine load (-7.1 +/- 2.3 mm Hg and -8.5 +/- 4.5%, respectively). After the high-fat meal, the decrease in blood pressure in response to L-arginine was reduced (-1 +/- 0.8 mm Hg), and platelet aggregation showed a paradoxical increase (4.1 +/- 2.1%; P < 0.01 compared with the high-carbohydrate meal). The high-fat meal with antioxidants partially restored the vascular response to L-arginine.Conclusion Compared with a high-carbohydrate meal, a high-fat meal can modify endothelial functions toward a more atherogenetic profile, which is partially prevented by dietary antioxidants.
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“Studies in experimental animals fed or injected with radiolabelled protein-bound AGE and human volunteers receiving diets enriched with MRP or specific AGE have shown that absorption of ingested MRP is variable and dependent on the MRP (464,465,527 -529) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [529]
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“Highly cross-linked AGE and melanoidins were predominantly excreted in the faeces while absorbed MRP were in general rapidly excreted by the kidney, with limited accumulation in tissues and organs (465,528 -531) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [529]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Self-citationThe Effects of Diet on Inflammation
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Self-citationThe l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio
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Esposito, K., & Giugliano, D. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi605 · Cited by 236
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Metadata
- Authors
- Esposito, K., Nappo, F., Giugliano, F., Giugliano, G., Marfella, R., & Giugliano, D.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Giugliano, Dario
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 77
- Issue
- 1
- Pages
- 139-143
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2114506239
- Cited by
- 113
- References
- 32
- Citations by year
- 2025: 1 · 2024: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 8 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- dietary antioxidants, endothelial dysfunction, high-fat meal, high-carbohydrate meal, postprandial response, L-arginine, nitric oxide, platelet aggregation, hemostasis, blood pressure, triglycerides, atherogenesis, coronary heart disease risk
- MeSH terms
- Adult, Antioxidants, Blood Pressure, Cholesterol, Dietary Carbohydrates, Dietary Fats, Endothelium, Vascular, Female, Humans, Male, Platelet Aggregation, Cross-Over Studies, Postprandial Period
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