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Cited by 113Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects

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Esposito, Katherine, Nappo, Francesco, Giugliano, Francesco, Giugliano, Giovanni, Marfella, Raffaele, Giugliano, Dario·2003·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/77.1.139
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Abstract

Background Persons following current dietary guidelines have a lower risk of mortality from coronary heart disease.Objective The objective was to compare the short-term effect of a high-fat meal and a high-carbohydrate meal, with and without dietary antioxidants, on vasomotor, antiplatelet, and hemostatic functions of the endothelium in healthy subjects.Design In an observer-blinded, randomized crossover study, 25 (13 men and 12 women) healthy subjects were given each of 3 meals in random order at 1-wk intervals: a high-fat meal (760 kcal), an isoenergetic high-carbohydrate meal, and a high-fat meal with dietary antioxidants from vegetables (865 kcal). Endothelial functions, as assessed by hemodynamic and rheologic responses to L-arginine--the natural precursor of nitric oxide--were evaluated before and 4 h after each meal.Results Unlike the high-carbohydrate meal, the high-fat meal increased the plasma concentrations of triacylglycerol (P < 0.01); both meals activated hemostasis. The high-carbohydrate meal did not modify blood pressure, and platelet aggregation decreased in response to the L-arginine load (-7.1 +/- 2.3 mm Hg and -8.5 +/- 4.5%, respectively). After the high-fat meal, the decrease in blood pressure in response to L-arginine was reduced (-1 +/- 0.8 mm Hg), and platelet aggregation showed a paradoxical increase (4.1 +/- 2.1%; P < 0.01 compared with the high-carbohydrate meal). The high-fat meal with antioxidants partially restored the vascular response to L-arginine.Conclusion Compared with a high-carbohydrate meal, a high-fat meal can modify endothelial functions toward a more atherogenetic profile, which is partially prevented by dietary antioxidants.

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Research works printed but not linked: 3

  1. Dawson-Saunders, 1990
  2. de Man, 1998, The acute effect of an artificial hypertriglyceridemia on endothelial function in healthy subjects, Eur Heart J., 19, 158
  3. Giugliano, 2001, The toxic trio: acute, chronic, and postprandial hyperglycemia, Nutr Metab Cardiovasc Dis, 11, 80

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Metadata

Authors
Esposito, K., Nappo, F., Giugliano, F., Giugliano, G., Marfella, R., & Giugliano, D.
Affiliations
University of Campania "Luigi Vanvitelli" (IT)
Corresponding author
Giugliano, Dario
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2003-01
Volume
77
Issue
1
Pages
139-143
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/77.1.139
OpenAlex
W2114506239
Cited by
113
References
32
Citations by year
2025: 1 · 2024: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 8 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 2
FWCI
4.94
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords
dietary antioxidants, endothelial dysfunction, high-fat meal, high-carbohydrate meal, postprandial response, L-arginine, nitric oxide, platelet aggregation, hemostasis, blood pressure, triglycerides, atherogenesis, coronary heart disease risk
MeSH terms
Adult, Antioxidants, Blood Pressure, Cholesterol, Dietary Carbohydrates, Dietary Fats, Endothelium, Vascular, Female, Humans, Male, Platelet Aggregation, Cross-Over Studies, Postprandial Period

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